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The map label for this gene is aceA [H]

Identifier: 52787884

GI number: 52787884

Start: 4037447

End: 4038718

Strand: Reverse

Name: aceA [H]

Synonym: BLi04207

Alternate gene names: 52787884

Gene position: 4038718-4037447 (Counterclockwise)

Preceding gene: 52787885

Following gene: 52787882

Centisome position: 95.64

GC content: 53.62

Gene sequence:

>1272_bases
ATGCTGAAAGAAAAACAACTCGCAGAAAGCTGGGAGCATGATGAACGCTGGAAAGGGATCACAAGGCCGTATGAGGCGGC
AGACGTCATTCGGCTGAGGGGCACGCTCGAGATTGAATACACGATTGCAAGGCGCGGCGCCGAAAAGCTGTGGAAGCTTC
TCCATACAGAGGATTTCGTCCCGGCGCTGGGCGCTTTGACCGGAAACCAAGCCATGCAGCAAGTAAAGGCCGGATTGAAA
GCGATTTATTTAAGCGGCTGGCAGGTGGCTGCCGATGCAAATATGTCAGGGAGCATGTATCCTGACCAAAGCCTTTATCC
GGCAAACAGCGTCCCGGAAGTCGTCAAAAAAATCAACCGCACGCTGCAGCGCGCCGATCAAATCCACCATATGGAAGGAA
AGGAAGACATCGATTGGTTTGCTCCGATTGTGGCCGACGCTGAAGCGGGCTTCGGCGGGCAGCTGAATGTGTTCGAGCTG
ATGAAAAGTATGATTGAAGCCGGCGCCGCGGGAGTTCACTTTGAAGACCAGCTGTCGTCTGAGAAAAAGTGCGGGCATTT
GGGCGGAAAAGTGCTGCTTCCGACGCAAACAGCGGTACGTAATTTGATTGCCGCGCGCCTCGCCGCAGACGTGATGGGAG
TCCCGACCATTCTTATTGCCCGCACGGACGCGAATGCGGCAGACCTGATCACAAGCGACGTCGATTCATATGATGCACCG
TTTTTGACGGGAGAGCGAACAGCGGAAGGGTTCTTCAAAACAAAGCCTGGCCTTGATCAGGCGATTGCCAGAGGCTTGGC
GTATGCGCCGTATGCCGATTTGATCTGGTGTGAAACGTCTGAGCCGAATATTGAAGAAGCCCGCCGGTTTGCACAGGCGA
TCCATGAAAAATTCCCGGGCAAACTGCTCGCCTACAACTGTTCCCCTTCGTTCAACTGGAAGGCCAAACTGGATGACAAC
ACGATCTTGAACTTCCAGAAACAGCTCAGTGAAATGGGCTATAAATTTCAATTTGTCACACTGGCGGGCTTCCACGCCTT
AAATCACGGCATGTTTGAATTGGCCCGCCAATATAAGCACCGCGGAATGGCGGCGTACTCTGATCTGCAGCAGGCCGAGT
TTGCCAGCGAAGTCCACGGCTATACGGCGACAAGGCATCAGCGCGAAGTCGGAACGAGCTACTTTGATGAAGTCGCCCAG
GTTGTGACAGGCGGGACTTCATCAACCACTGCACTGAAGGGATCGACTGAAGCGGAACAGTTTCAATCATAA

Upstream 100 bases:

>100_bases
AAGAGGCCGGACAGTTATTTGAACAGCTGATTTTGGATGATGAATTCGCGGAGTTTCTAACGATACCGGCTTATGAAAAT
ATATAATGGGGGAATGTGCG

Downstream 100 bases:

>100_bases
AAACGTGAAAAAGCCGCCCGTCATTGGGCGGCTTGCTTGTTGTCTATCAAGTTAGCAATTGACATCATTGGAAGGGGCGG
TAAAAGAGTTTTCCCTAATA

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLKEKQLAESWEHDERWKGITRPYEAADVIRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANMSGSMYPDQSLYPANSVPEVVKKINRTLQRADQIHHMEGKEDIDWFAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKPGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDN
TILNFQKQLSEMGYKFQFVTLAGFHALNHGMFELARQYKHRGMAAYSDLQQAEFASEVHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS

Sequences:

>Translated_423_residues
MLKEKQLAESWEHDERWKGITRPYEAADVIRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANMSGSMYPDQSLYPANSVPEVVKKINRTLQRADQIHHMEGKEDIDWFAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKPGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDN
TILNFQKQLSEMGYKFQFVTLAGFHALNHGMFELARQYKHRGMAAYSDLQQAEFASEVHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS
>Mature_423_residues
MLKEKQLAESWEHDERWKGITRPYEAADVIRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANMSGSMYPDQSLYPANSVPEVVKKINRTLQRADQIHHMEGKEDIDWFAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKPGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDN
TILNFQKQLSEMGYKFQFVTLAGFHALNHGMFELARQYKHRGMAAYSDLQQAEFASEVHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=427, Percent_Identity=65.5737704918033, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1786525, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982926, Length=415, Percent_Identity=64.0963855421687, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17561814, Length=415, Percent_Identity=64.0963855421687, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6320908, Length=325, Percent_Identity=37.2307692307692, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=259, Percent_Identity=36.6795366795367, Blast_Score=159, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46824; Mature: 46824

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEKQLAESWEHDERWKGITRPYEAADVIRLRGTLEIEYTIARRGAEKLWKLLHTEDFV
CCCHHHHHHHCCHHHHHCCCCCCCHHHHHEEECCEEEEEEHHHHHHHHHHHHHHHHHHHH
PALGALTGNQAMQQVKAGLKAIYLSGWQVAADANMSGSMYPDQSLYPANSVPEVVKKINR
HHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLQRADQIHHMEGKEDIDWFAPIVADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQLSS
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
EKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
HHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCC
FLTGERTAEGFFKTKPGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPG
CCCCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KLLAYNCSPSFNWKAKLDDNTILNFQKQLSEMGYKFQFVTLAGFHALNHGMFELARQYKH
CEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
RGMAAYSDLQQAEFASEVHGYTATRHQREVGTSYFDEVAQVVTGGTSSTTALKGSTEAEQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
FQS
HCC
>Mature Secondary Structure
MLKEKQLAESWEHDERWKGITRPYEAADVIRLRGTLEIEYTIARRGAEKLWKLLHTEDFV
CCCHHHHHHHCCHHHHHCCCCCCCHHHHHEEECCEEEEEEHHHHHHHHHHHHHHHHHHHH
PALGALTGNQAMQQVKAGLKAIYLSGWQVAADANMSGSMYPDQSLYPANSVPEVVKKINR
HHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLQRADQIHHMEGKEDIDWFAPIVADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQLSS
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
EKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
HHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCC
FLTGERTAEGFFKTKPGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPG
CCCCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KLLAYNCSPSFNWKAKLDDNTILNFQKQLSEMGYKFQFVTLAGFHALNHGMFELARQYKH
CEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
RGMAAYSDLQQAEFASEVHGYTATRHQREVGTSYFDEVAQVVTGGTSSTTALKGSTEAEQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
FQS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]