Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 52786724

GI number: 52786724

Start: 2873477

End: 2875240

Strand: Reverse

Name: sdhA [H]

Synonym: BLi02993

Alternate gene names: 52786724

Gene position: 2875240-2873477 (Counterclockwise)

Preceding gene: 52786725

Following gene: 52786723

Centisome position: 68.09

GC content: 51.81

Gene sequence:

>1764_bases
ATGAGCAATTCAAGCATCATCGTTGTCGGCGGAGGACTAGCGGGTCTGATGGCGACCATTAAAGCTGCGGAAGCAGGAAC
AAATGTAAAACTATTTTCGATCGTTCCCGTTAAGCGCTCACATTCCGTATGTGCGCAGGGCGGAATCAACGGAGCGGTCA
ATACAAAAGGTGAAGGAGACTCCCCATGGGAGCATTTTGACGACACGGTGTACGGAGGCGACTTTCTGGCGAACCAGCCG
CCGGTCAAAGCGATGTGTGAAGCGGCGCCGTCGATCATTCATTTGCTTGACCGCATGGGCGTCATGTTTAACAGAACGCC
TGAAGGGCTGCTTGACTTCCGGCGCTTCGGAGGAACCCAGCATCACAGAACGGCATATGCGGGGGCGACGACCGGACAGC
AGCTCTTGTACGCGCTGGATGAGCAGGTTCGCCGCTTCGAAGTTGAAGGGCTCGTTTCGAAATATGAAGGCTGGGAGTTT
CTCGGAGCCGTTCTTGATGATGACAATACGTGCAGGGGCATCGTCGCCCAAAACTTAACGACGATGGAAATCGAGTCGTT
CCGTTCGGACGCAGTCATCATGGCGACCGGGGGGCCGGGCATCATCTTCGGAAAATCGACGAACTCGATGATCAATACCG
GATCAGCCGCTTCGATCGTTTACCAGCAGGGTGCTTACTATGCGAACGGAGAGTTCATCCAGATCCATCCGACCGCCATT
CCTGGAGACGACAAGCTGCGGCTGATGAGCGAATCGGCGCGCGGTGAAGGCGGACGAGTCTGGACGTATAAAGACGGCAA
GCCTTGGTATTTCCTCGAAGAGAAATATCCGGCATATGGAAACCTTGTGCCGCGTGATATTGCGACGCGTGAAATATTTG
ATGTGTGCGTCAGACAAAAGCTCGGCATCAACGGCGAAAACATGGTTTATCTCGATCTTTCCCACAAAGATCCGAAGGAA
TTGGACATCAAGCTGGGCGGAATCATTGAAATCTATGAAAAATTCATGGGTGACGATCCGCGCAAGCTGCCGATGAAAAT
CTTCCCTGCGGTTCACTACTCAATGGGCGGACTTTGGGTCGACTACGATCAGATGACCAACATTCCTGGACTGTTTGCCG
CGGGAGAATGCGACTATTCGATGCACGGCGGAAACCGCCTGGGAGCGAACTCGCTCTTGTCAGCCATTTACGGCGGCATG
GTGGCAGGTCCGAAAGCCGTTGAATACATTCAAGGTCTCGAAACATCCGCAGAAGATCTGTCTTCTTCCGTTTTCGATGC
ATACGTCAAAAAGGAAGAAGAAAAGTGGGCTGACATAATGAAAATGGACGGCAATGAAAATGCTTATGTCCTTCATAAAG
AGCTCGGCGAATGGATGACAGACAACGTGACGGTCGTGCGCTACAATGACAAGCTGCTGAAAACGGATGAAAAAATCCAA
GAGCTTGCCGAGCGCTACCGAAACATCAATATCAACGATACGGCAAAATGGAGCAACCAGGGCGCCGTATTCACGCGCCA
GCTGCACAACATGCTGCAATTGGCACGGGTGATCACGCTCGGTGCATACAACCGGAATGAGAGCCGCGGCGCCCATTATA
AACCGGATTTCCCTGAACGTAATGACGAGGAATGGCTGAAAACAACAATGGCGAAACATGCAGGCGATTTTGAAGCCCCG
AAATTCCATTATGAGGATGTCGATGTTTCATTAATCGCACCGCGTAAACGGGATTACTCGAAGAAAAAGGTGGCGAAATC
ATGA

Upstream 100 bases:

>100_bases
TGTGACAATGGGAGTCTTTGTTGTGCTGTCCTATGTAGGGCTGAGAGCGATTTTGGCATTTGTGTAAAAGAACTAGATTA
CTAGAGGGAGTGGGGCAGGC

Downstream 100 bases:

>100_bases
GTGAAAATAAGACAATCAAGTTTATCATCACTCGTCAGGATACATCGGATTCTAATCCTTACCAGGAAGAGTTTGAAATT
CCATACCGTCCGAATATGAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MSNSSIIVVGGGLAGLMATIKAAEAGTNVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRFEVEGLVSKYEGWEF
LGAVLDDDNTCRGIVAQNLTTMEIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVRQKLGINGENMVYLDLSHKDPKE
LDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPKAVEYIQGLETSAEDLSSSVFDAYVKKEEEKWADIMKMDGNENAYVLHKELGEWMTDNVTVVRYNDKLLKTDEKIQ
ELAERYRNININDTAKWSNQGAVFTRQLHNMLQLARVITLGAYNRNESRGAHYKPDFPERNDEEWLKTTMAKHAGDFEAP
KFHYEDVDVSLIAPRKRDYSKKKVAKS

Sequences:

>Translated_587_residues
MSNSSIIVVGGGLAGLMATIKAAEAGTNVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRFEVEGLVSKYEGWEF
LGAVLDDDNTCRGIVAQNLTTMEIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVRQKLGINGENMVYLDLSHKDPKE
LDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPKAVEYIQGLETSAEDLSSSVFDAYVKKEEEKWADIMKMDGNENAYVLHKELGEWMTDNVTVVRYNDKLLKTDEKIQ
ELAERYRNININDTAKWSNQGAVFTRQLHNMLQLARVITLGAYNRNESRGAHYKPDFPERNDEEWLKTTMAKHAGDFEAP
KFHYEDVDVSLIAPRKRDYSKKKVAKS
>Mature_586_residues
SNSSIIVVGGGLAGLMATIKAAEAGTNVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPP
VKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRFEVEGLVSKYEGWEFL
GAVLDDDNTCRGIVAQNLTTMEIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVRQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPKAVEYIQGLETSAEDLSSSVFDAYVKKEEEKWADIMKMDGNENAYVLHKELGEWMTDNVTVVRYNDKLLKTDEKIQE
LAERYRNININDTAKWSNQGAVFTRQLHNMLQLARVITLGAYNRNESRGAHYKPDFPERNDEEWLKTTMAKHAGDFEAPK
FHYEDVDVSLIAPRKRDYSKKKVAKS

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=30.8243727598566, Blast_Score=227, Evalue=3e-59,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=33.5087719298246, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=32.7898550724638, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=28.8256227758007, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17505833, Length=547, Percent_Identity=31.8098720292505, Blast_Score=228, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=544, Percent_Identity=31.9852941176471, Blast_Score=227, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=32.3049001814882, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=30.9859154929577, Blast_Score=226, Evalue=8e-60,
Organism=Drosophila melanogaster, GI17137288, Length=594, Percent_Identity=31.1447811447811, Blast_Score=235, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24655642, Length=594, Percent_Identity=31.1447811447811, Blast_Score=235, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24655647, Length=594, Percent_Identity=31.1447811447811, Blast_Score=235, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24663005, Length=606, Percent_Identity=30.3630363036304, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65272; Mature: 65140

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSIIVVGGGLAGLMATIKAAEAGTNVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRFEVEGLVSKYEGWEFLGAVLDDDNTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHEECCCCCCCHHHHCCCE
TMEIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
EEEHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVRQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPKAVEYIQGLETSAEDL
EHHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHH
SSSVFDAYVKKEEEKWADIMKMDGNENAYVLHKELGEWMTDNVTVVRYNDKLLKTDEKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCEEEEEECCHHHCCHHHHH
ELAERYRNININDTAKWSNQGAVFTRQLHNMLQLARVITLGAYNRNESRGAHYKPDFPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEEWLKTTMAKHAGDFEAPKFHYEDVDVSLIAPRKRDYSKKKVAKS
CHHHHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCCCCHHHHCCC
>Mature Secondary Structure 
SNSSIIVVGGGLAGLMATIKAAEAGTNVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRFEVEGLVSKYEGWEFLGAVLDDDNTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHEECCCCCCCHHHHCCCE
TMEIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
EEEHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVRQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPKAVEYIQGLETSAEDL
EHHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHH
SSSVFDAYVKKEEEKWADIMKMDGNENAYVLHKELGEWMTDNVTVVRYNDKLLKTDEKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCEEEEEECCHHHCCHHHHH
ELAERYRNININDTAKWSNQGAVFTRQLHNMLQLARVITLGAYNRNESRGAHYKPDFPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEEWLKTTMAKHAGDFEAPKFHYEDVDVSLIAPRKRDYSKKKVAKS
CHHHHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]