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The map label for this gene is hemA

Identifier: 52786679

GI number: 52786679

Start: 2831531

End: 2832892

Strand: Reverse

Name: hemA

Synonym: BLi02947

Alternate gene names: 52786679

Gene position: 2832892-2831531 (Counterclockwise)

Preceding gene: 52786681

Following gene: 52786678

Centisome position: 67.09

GC content: 49.05

Gene sequence:

>1362_bases
ATGCATATACTTGTCGTGGGATTGGATTACAAATCAGCCCCTGTTGATATACGTGAAAAGTTAACCTTTCAGCCGGATGA
GCTGGGGCAGGCGATGGCGCAATTGAAAGAAGAAAAAAGCATACTTGAGAACATCATCGTGTCGACATGCAACCGGACAG
AGCTGTATGCAGTCGTTGATCAGCTGCACACCGGACGTTATTATATGAAAATGTTTTTGGCGAACTGGTTCGGATTAAGC
AAAGAGGACATTTCGCCTTACTTGAAGTTTTATGAAAACGACGGGGCCGTTGAACACCTGTTCCGCGTATCGTGCGGATT
GGATTCGATGGTTATTGGAGAAACGCAGATTTTGGGCCAAGTGCGTACAAGTTTTAAGCTGGCTCAGGAAGAGAAGACAA
TTGGTACCGTTTTCAACTATTTGTTTAAGCAGGCGGTCACGGTCGCAAAGCGCTGCCATGCCGAAACGGACATTGCTTCA
AATGCTGTATCCGTCAGCTATGCCGCCGTCGAGCTTGCCAGGAAAATCTTCGGCGACCTTTCCGATAAACACGTGCTGAT
TCTCGGGGCGGGCAAAATGGGTGAGCTTGCGGTTCAAAACCTGCACGGCCACGGAATCGGACAGGTTACGGTGATCAACA
GAACATTTTCAAAAGCGAAGGAGCTTGCCGGCCGTTTTTCAGGCGCGGCGAAAAGCTTGAATGAGCTGCAATGCGCTTTG
ATGGAAGCCGATATTCTCATCAGTTCGACCGGCGCCAGCGGCTATGTCGTCACAAAAGAGATGATCGAACATGTCAATAA
GCTTCGCAAAGGCTGTCCGCTTTTTATGGTGGACATTGCCGTGCCGCGGGATCTTGACCCGGCTCTCAGCGAAGTGGAAG
GCGTCTTCCTGTACGATATTGACGATCTTGAAGGGATCGTCGAAGAAAATTTGAAGGAACGCCAGGCCGTTGCCGAAGAG
GTGGAGCTGATTATTGAAGCTGAGATCGTTTCTTTTAAACAATGGCTGAATACGCTCGGCGTCGTGCCGGTCATCTCGGC
TCTCAGGGAAAAAGCCTTGACGATCCAGGCGGAAACGATGCAGAGCATCGAACGGAAGCTCCCTCATTTGAGCACAAGGG
AGAAAAAACTTTTAAACAAGCATACGAAAAGCATTATCAACCAGCTTTTGCGCGACCCGATTTTAAAAGTGAAGGAGTTT
GCGTCAGAAGCTGATGCCGAAGAAAAGCTTGCACTGTTCACGCAGATTTTTGATATTGAAGAAGCGGCTTTTCCTGACGG
TGAGAGACAAGACGAACGTCAGCCGGTTCATGCGTTTAAGCGGCAAAATCCGCAGGGTTTGACTTCTATCGCGAGCGAGT
GA

Upstream 100 bases:

>100_bases
AAGAGAAAATAGTGAATATATGTTATAATCGTTTTGAATAATAAATTCTATATTATAATCATTCTAATTTAGATAGATGT
TGGGGGTGCAAGCAAGAGTT

Downstream 100 bases:

>100_bases
CAGACATGACAGACACATTGTTAGCAAGGCTTAACGAAGTTACAATCGTGTTGTACGCGTTCACCGTTCTCTTTTATTTT
ATAGACTTTTTACAGCACAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MHILVVGLDYKSAPVDIREKLTFQPDELGQAMAQLKEEKSILENIIVSTCNRTELYAVVDQLHTGRYYMKMFLANWFGLS
KEDISPYLKFYENDGAVEHLFRVSCGLDSMVIGETQILGQVRTSFKLAQEEKTIGTVFNYLFKQAVTVAKRCHAETDIAS
NAVSVSYAAVELARKIFGDLSDKHVLILGAGKMGELAVQNLHGHGIGQVTVINRTFSKAKELAGRFSGAAKSLNELQCAL
MEADILISSTGASGYVVTKEMIEHVNKLRKGCPLFMVDIAVPRDLDPALSEVEGVFLYDIDDLEGIVEENLKERQAVAEE
VELIIEAEIVSFKQWLNTLGVVPVISALREKALTIQAETMQSIERKLPHLSTREKKLLNKHTKSIINQLLRDPILKVKEF
ASEADAEEKLALFTQIFDIEEAAFPDGERQDERQPVHAFKRQNPQGLTSIASE

Sequences:

>Translated_453_residues
MHILVVGLDYKSAPVDIREKLTFQPDELGQAMAQLKEEKSILENIIVSTCNRTELYAVVDQLHTGRYYMKMFLANWFGLS
KEDISPYLKFYENDGAVEHLFRVSCGLDSMVIGETQILGQVRTSFKLAQEEKTIGTVFNYLFKQAVTVAKRCHAETDIAS
NAVSVSYAAVELARKIFGDLSDKHVLILGAGKMGELAVQNLHGHGIGQVTVINRTFSKAKELAGRFSGAAKSLNELQCAL
MEADILISSTGASGYVVTKEMIEHVNKLRKGCPLFMVDIAVPRDLDPALSEVEGVFLYDIDDLEGIVEENLKERQAVAEE
VELIIEAEIVSFKQWLNTLGVVPVISALREKALTIQAETMQSIERKLPHLSTREKKLLNKHTKSIINQLLRDPILKVKEF
ASEADAEEKLALFTQIFDIEEAAFPDGERQDERQPVHAFKRQNPQGLTSIASE
>Mature_453_residues
MHILVVGLDYKSAPVDIREKLTFQPDELGQAMAQLKEEKSILENIIVSTCNRTELYAVVDQLHTGRYYMKMFLANWFGLS
KEDISPYLKFYENDGAVEHLFRVSCGLDSMVIGETQILGQVRTSFKLAQEEKTIGTVFNYLFKQAVTVAKRCHAETDIAS
NAVSVSYAAVELARKIFGDLSDKHVLILGAGKMGELAVQNLHGHGIGQVTVINRTFSKAKELAGRFSGAAKSLNELQCAL
MEADILISSTGASGYVVTKEMIEHVNKLRKGCPLFMVDIAVPRDLDPALSEVEGVFLYDIDDLEGIVEENLKERQAVAEE
VELIIEAEIVSFKQWLNTLGVVPVISALREKALTIQAETMQSIERKLPHLSTREKKLLNKHTKSIINQLLRDPILKVKEF
ASEADAEEKLALFTQIFDIEEAAFPDGERQDERQPVHAFKRQNPQGLTSIASE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=411, Percent_Identity=34.7931873479319, Blast_Score=255, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_BACLD (Q65GJ9)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080091.1
- RefSeq:   YP_092508.1
- HSSP:   Q9UXR8
- ProteinModelPortal:   Q65GJ9
- SMR:   Q65GJ9
- STRING:   Q65GJ9
- EnsemblBacteria:   EBBACT00000056997
- EnsemblBacteria:   EBBACT00000058988
- GeneID:   3028037
- GeneID:   3098403
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02947
- KEGG:   bli:BL00623
- NMPDR:   fig|279010.5.peg.3274
- eggNOG:   COG0373
- GeneTree:   EBGT00050000001402
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   BLIC279010-1:BLI02947-MONOMER
- BioCyc:   BLIC279010:BL00623-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50541; Mature: 50541

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVVGLDYKSAPVDIREKLTFQPDELGQAMAQLKEEKSILENIIVSTCNRTELYAVVD
CEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYMKMFLANWFGLSKEDISPYLKFYENDGAVEHLFRVSCGLDSMVIGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHHHHH
VRTSFKLAQEEKTIGTVFNYLFKQAVTVAKRCHAETDIASNAVSVSYAAVELARKIFGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCC
SDKHVLILGAGKMGELAVQNLHGHGIGQVTVINRTFSKAKELAGRFSGAAKSLNELQCAL
CCCEEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEADILISSTGASGYVVTKEMIEHVNKLRKGCPLFMVDIAVPRDLDPALSEVEGVFLYDI
HHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCEEEEEC
DDLEGIVEENLKERQAVAEEVELIIEAEIVSFKQWLNTLGVVPVISALREKALTIQAETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
QSIERKLPHLSTREKKLLNKHTKSIINQLLRDPILKVKEFASEADAEEKLALFTQIFDIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EAAFPDGERQDERQPVHAFKRQNPQGLTSIASE
HHCCCCCCCCCCCCHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MHILVVGLDYKSAPVDIREKLTFQPDELGQAMAQLKEEKSILENIIVSTCNRTELYAVVD
CEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYMKMFLANWFGLSKEDISPYLKFYENDGAVEHLFRVSCGLDSMVIGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHHHHH
VRTSFKLAQEEKTIGTVFNYLFKQAVTVAKRCHAETDIASNAVSVSYAAVELARKIFGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCC
SDKHVLILGAGKMGELAVQNLHGHGIGQVTVINRTFSKAKELAGRFSGAAKSLNELQCAL
CCCEEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEADILISSTGASGYVVTKEMIEHVNKLRKGCPLFMVDIAVPRDLDPALSEVEGVFLYDI
HHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCEEEEEC
DDLEGIVEENLKERQAVAEEVELIIEAEIVSFKQWLNTLGVVPVISALREKALTIQAETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
QSIERKLPHLSTREKKLLNKHTKSIINQLLRDPILKVKEFASEADAEEKLALFTQIFDIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EAAFPDGERQDERQPVHAFKRQNPQGLTSIASE
HHCCCCCCCCCCCCHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA