Click here to switch to the map view.

The map label for this gene is yrhB [H]

Identifier: 52786587

GI number: 52786587

Start: 2742836

End: 2743978

Strand: Reverse

Name: yrhB [H]

Synonym: BLi02853

Alternate gene names: 52786587

Gene position: 2743978-2742836 (Counterclockwise)

Preceding gene: 52786588

Following gene: 52786586

Centisome position: 64.98

GC content: 51.18

Gene sequence:

>1143_bases
ATGAAGCCAAAAACGAAAATGATTCACGGCGGAATTACAGGAGACGAAAAAACAGGAGCGGTATCGGTTCCTATCTATCA
GGTCAGCACGTACAAACAGCCTCGCGCCGGCCAGCATACAGGATACGAATATTCCCGGACGGGAAATCCGACGAGAACGG
CGCTCGAATCCTTGATCGCGGATGTTGAAGGCGGTGCAGCAGGCTATGCGTTCGGCTCTGGGATGGCGGCGATCACAGCC
GTCATGATGCTTTTTAAAAGCGGCGATCACATCGTATTGACAGATGATGTATACGGCGGCACCTACCGCGTGATGACAAA
GGTATTGAATCGCATCGGCATTGAAGCGACCTTCAGTGATACGAGCAGCATCGAAGACATCGAAAAAGCGATCAAGCCGA
ATACAAAAGCGATTTATGTTGAGACGCCGACAAATCCTTTATTGAAAATCACTGACATCAAGAAAACTGCTGAAACAGCG
AAAAAGCACGACTTATTGCTGATTGTCGACAACACCTTCTACACGCCGTACTTTCAAAATCCAATCTCGTTGGGAGCCGA
TATCGTCCTCCACAGCGCGACGAAGTACTTGGGCGGACACAGCGATGTCGTCGGCGGACTTGTCGTAGCAGCCTCGAAGG
AACTCGCAGAAGAGATCCATTTCATTCAAAACTCTACAGGCGGGATTCTCGGGCCTCAGGATTCCTGGCTCTTAATGAGG
GGGATGAAAACCCTTGGCTTGAGAATGGAAGCCCATGAGCAAAATGCCCGGAAAATCGCGGCGTTTTTAGACGATCATCC
CGCCGTCAAAAAGGTTTATTACCCAGGGCTGCCGTCCCATCCGGGACATGAGCTTGCCAAGCGGCAAAGTACGGGCTTCG
GAGGCATGATCTCGTTTGATATCGGAAAAGAAGAGAACGTGGACCTTGTCCTTGGCCGTTTGAAATGGTTTACGATCGCC
GAAAGCCTTGGTGCGGTTGAAAGTCTGATATCGGTGCCGGCGCGAATGACTCATGCTTCGATCCCGCCTGAACGCAGGCT
GGAGCTTGGCATCACAGACGGATTAATCCGTATTTCCGCCGGGGTTGAGGATATTGACGATCTGTTGGAAGACTTGCAGC
AAGCGCTGGCCCCTCTTTCTTAA

Upstream 100 bases:

>100_bases
GAAGCCGAAAAAGCGAAAGCCGGCACAAACATTGTGACGATTTTTCCCGACAGCAGCGACCGCTATTTAAGCAAAAAAAT
TTACGAAGGAGGAATATGAT

Downstream 100 bases:

>100_bases
AATGGCTGAATTTACATGTCTGGTCATCTGTCAATCTATGTTATTCTCAAATCATATCCATTATGAAACAAAAGCAGGTG
ATCATGACATGCAGAAGAAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKPKTKMIHGGITGDEKTGAVSVPIYQVSTYKQPRAGQHTGYEYSRTGNPTRTALESLIADVEGGAAGYAFGSGMAAITA
VMMLFKSGDHIVLTDDVYGGTYRVMTKVLNRIGIEATFSDTSSIEDIEKAIKPNTKAIYVETPTNPLLKITDIKKTAETA
KKHDLLLIVDNTFYTPYFQNPISLGADIVLHSATKYLGGHSDVVGGLVVAASKELAEEIHFIQNSTGGILGPQDSWLLMR
GMKTLGLRMEAHEQNARKIAAFLDDHPAVKKVYYPGLPSHPGHELAKRQSTGFGGMISFDIGKEENVDLVLGRLKWFTIA
ESLGAVESLISVPARMTHASIPPERRLELGITDGLIRISAGVEDIDDLLEDLQQALAPLS

Sequences:

>Translated_380_residues
MKPKTKMIHGGITGDEKTGAVSVPIYQVSTYKQPRAGQHTGYEYSRTGNPTRTALESLIADVEGGAAGYAFGSGMAAITA
VMMLFKSGDHIVLTDDVYGGTYRVMTKVLNRIGIEATFSDTSSIEDIEKAIKPNTKAIYVETPTNPLLKITDIKKTAETA
KKHDLLLIVDNTFYTPYFQNPISLGADIVLHSATKYLGGHSDVVGGLVVAASKELAEEIHFIQNSTGGILGPQDSWLLMR
GMKTLGLRMEAHEQNARKIAAFLDDHPAVKKVYYPGLPSHPGHELAKRQSTGFGGMISFDIGKEENVDLVLGRLKWFTIA
ESLGAVESLISVPARMTHASIPPERRLELGITDGLIRISAGVEDIDDLLEDLQQALAPLS
>Mature_380_residues
MKPKTKMIHGGITGDEKTGAVSVPIYQVSTYKQPRAGQHTGYEYSRTGNPTRTALESLIADVEGGAAGYAFGSGMAAITA
VMMLFKSGDHIVLTDDVYGGTYRVMTKVLNRIGIEATFSDTSSIEDIEKAIKPNTKAIYVETPTNPLLKITDIKKTAETA
KKHDLLLIVDNTFYTPYFQNPISLGADIVLHSATKYLGGHSDVVGGLVVAASKELAEEIHFIQNSTGGILGPQDSWLLMR
GMKTLGLRMEAHEQNARKIAAFLDDHPAVKKVYYPGLPSHPGHELAKRQSTGFGGMISFDIGKEENVDLVLGRLKWFTIA
ESLGAVESLISVPARMTHASIPPERRLELGITDGLIRISAGVEDIDDLLEDLQQALAPLS

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=375, Percent_Identity=50.9333333333333, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI299473759, Length=375, Percent_Identity=46.9333333333333, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI25453487, Length=374, Percent_Identity=44.9197860962567, Blast_Score=288, Evalue=7e-78,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=43.7665782493369, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=29.2929292929293, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17560056, Length=357, Percent_Identity=49.5798319327731, Blast_Score=347, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17538055, Length=377, Percent_Identity=48.5411140583554, Blast_Score=343, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=42.7027027027027, Blast_Score=297, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6321254, Length=399, Percent_Identity=34.3358395989975, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323333, Length=429, Percent_Identity=37.0629370629371, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321170, Length=288, Percent_Identity=37.1527777777778, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321904, Length=347, Percent_Identity=33.1412103746398, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322970, Length=349, Percent_Identity=26.3610315186246, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323557, Length=342, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322590, Length=258, Percent_Identity=25.1937984496124, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=49.2021276595745, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41121; Mature: 41121

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKTKMIHGGITGDEKTGAVSVPIYQVSTYKQPRAGQHTGYEYSRTGNPTRTALESLIA
CCCCCCEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
DVEGGAAGYAFGSGMAAITAVMMLFKSGDHIVLTDDVYGGTYRVMTKVLNRIGIEATFSD
HCCCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCEEECCC
TSSIEDIEKAIKPNTKAIYVETPTNPLLKITDIKKTAETAKKHDLLLIVDNTFYTPYFQN
CCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVGGLVVAASKELAEEIHFIQNSTGGILGPQDSWLLMR
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GMKTLGLRMEAHEQNARKIAAFLDDHPAVKKVYYPGLPSHPGHELAKRQSTGFGGMISFD
HHHHHCCEEHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCHHHHHHCCCCCCCEEEEE
IGKEENVDLVLGRLKWFTIAESLGAVESLISVPARMTHASIPPERRLELGITDGLIRISA
CCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCEEECCCCCEEEEEC
GVEDIDDLLEDLQQALAPLS
CHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPKTKMIHGGITGDEKTGAVSVPIYQVSTYKQPRAGQHTGYEYSRTGNPTRTALESLIA
CCCCCCEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
DVEGGAAGYAFGSGMAAITAVMMLFKSGDHIVLTDDVYGGTYRVMTKVLNRIGIEATFSD
HCCCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCEEECCC
TSSIEDIEKAIKPNTKAIYVETPTNPLLKITDIKKTAETAKKHDLLLIVDNTFYTPYFQN
CCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVGGLVVAASKELAEEIHFIQNSTGGILGPQDSWLLMR
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GMKTLGLRMEAHEQNARKIAAFLDDHPAVKKVYYPGLPSHPGHELAKRQSTGFGGMISFD
HHHHHCCEEHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCHHHHHHCCCCCCCEEEEE
IGKEENVDLVLGRLKWFTIAESLGAVESLISVPARMTHASIPPERRLELGITDGLIRISA
CCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCEEECCCCCEEEEEC
GVEDIDDLLEDLQQALAPLS
CHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]