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The map label for this gene is pbpA [H]

Identifier: 52786413

GI number: 52786413

Start: 2579997

End: 2582117

Strand: Reverse

Name: pbpA [H]

Synonym: BLi02677

Alternate gene names: 52786413

Gene position: 2582117-2579997 (Counterclockwise)

Preceding gene: 52786414

Following gene: 52786412

Centisome position: 61.15

GC content: 45.21

Gene sequence:

>2121_bases
ATGATGAACAAAAAAATGAAAAATGAAAAACGCAAATCGCTCCCCATCAGGTTGAACATATTGTTCCTTCTCGCTTTTAT
TATTTTCACCATCGTCGTCGTGCGCCTCGGCATGGTGCAGATCGTCTTTGGCGAAGACTATACGAACGAAGTGCAGAAGC
AGGAAGAAGTCGATGTCTCGACAAGCGTTCCGCGGGGGAAAATATATGACCGGAACTTGAATACGATCGTGAAAAATAAA
CCGATGAATGCCATTACATACACAAGGACATCATCGACCTCTCAGGAGGACAGGCTCAAAATAGCAAAAAAACTTGCAGA
AATGATCAAAATCGATACAGATAAAATAACGGAGCGCGATAAAAAGGACTACTGGATTTTAACGCGCCCGAAAGAAGCCG
AGAAGCTCATCACCGATGAGGACCGGAAAAAAGTCAAGGACGGCAAGCTGAAGGAAGACGATTTATACCAGCTGCAGCTT
GACAGGATCACGGAAGATAAACTGAATGAATTGACAGATCAAGATTTGAAAGTCTTGGCAATCAAGCGTCAGATGGATTC
TGGATACGCGCTGACTCCGCAGTATATTAAAAACAAAGGTGTAACTGCAAAAGAAATGGCGGTTGTCAGCGAACACCTGG
ACGAGCTCCCGGGAGTCGATGTGACGTCTGATTGGAAGCGGGATTATCCTTATAACGGTCTGCTCAGAACGATGATCGGC
AGCATATCCGATTCAAATGAAGGGCTTCCGAAAAGCCTGCTTGATCATTATTTGTCGCTCGGCTACAACCGGAATGACCG
CGTCGGAAAAAGCTACCTCGAAGCCGAATATGAAAATGTGCTTCAGGGACAGAAAGAGAAAGTGAAAAATATTACCAATA
AATCAGGGGATATCGTCGATACGGAAGTCATTTCCGAGGGGAAAAGCGGAAAGGATTTAGTCTTGACGATTGATGTTGAT
ATGCAAAAAGCGATTGAAAAAATTGTCGAGGATGAACTGAAGTCTGCCAAAGCCAAGCATAGCGCTCCGCTTCTCGACCG
CGCATTCGTCGTTATGATGGATCCGCGAAACGGGGAAGTGTTATCGATTGCCGGCAAACAGCTTAAAAACGAAAGCGGCA
AATTAAAGGTTGACGACTATGCGCTCGGCGCGATGACGTCTTCTTATGCGATGGGCTCGGCTGTCAAAGGGGCCACTGTT
TTAACAGGTCTGCAGACGGGAGCCATTAATTTAAATACGACTTTTCTTGATGAACCGCTCTATATCGGAAAAGGAAAACC
GAAAAAATCTTGGGCGAGCAACTTGGGAACACTGGGTATCCAGGGAGCTCTTGAAAAGTCTTCAAACGTGTTCATGTTTA
AAACGGCGATCGCCCTTGGTAAAGGCCAATATAAGGCGCATCAGCCGCTCGACCTTCAAACAAAAGCATTTGATACATTC
AGGTATTATTTCAGCCAGTTCGGCCTCGGCGTCAAAACCGGAATCGATCTGCCAAATGAAGCTTCAGGCTACAAAGGATC
TCAAAGACTGCCCGGTTTCCTGCTTGACTTTTCCATCGGACAGTATGACACATACACACCGCTGCAGCTGGCTCAGTACG
TGTCAACGATTGCCAATGGGGGATACCGCATGAAGCCGCAGCTTGTGAAAGAGATCAGAGAGCCCGATTCGAAAAAAGGA
ATCGGAGCCGTTACACAGTCTGTGCAGCCTGAAGTATTGAACAAAGTGGACATGAGCGATGAATATATAAAAGAAGTCCA
GAAAGGATTCAGGCGCGTAATGACAAAAGGTACGGCAGCGGGACAGTTTGCCTCTGCTTCATATAAACCAGCTGGAAAAA
CAGGAACGGCCCAGTCTTTCTATGACGGACCGGACAAATCGAAAACGGGAACATCGACATACAATACAACGCTTGTTGCC
TACGCACCTTACGATAATCCGGAAGTCGCTATTTCCGTCGTCGTTCCTTGGGTTTATAATGACTATGGCCAGAGATATTC
GATCACAAACGAAATCGGCCGAAAAGTGCTTGATAAGTATTTTGAACTGAAATCAAAACAATCAAAAGAAAATACTGTCG
AAAAAAATAAAGACAAAATCGAAAAAGAAGCTACAGAATAG

Upstream 100 bases:

>100_bases
CCCCAAGGGAAAATAGTAGAAAAATGCCGAAAAAAACTTTACAATATATTTGGCACCTTTTCATAAGGTGTCTTTTCTTT
ATTTCAAAAAGGTGATGCTA

Downstream 100 bases:

>100_bases
GACTTTTTCATTAAAACACCTGCATTGAACCATGCAGGTGTTTTTTTGTGCGCCCGTTCTTTTCGTGCGCATTCTATACA
AAGTTCAAGCTTAATTTACA

Product: PbpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MMNKKMKNEKRKSLPIRLNILFLLAFIIFTIVVVRLGMVQIVFGEDYTNEVQKQEEVDVSTSVPRGKIYDRNLNTIVKNK
PMNAITYTRTSSTSQEDRLKIAKKLAEMIKIDTDKITERDKKDYWILTRPKEAEKLITDEDRKKVKDGKLKEDDLYQLQL
DRITEDKLNELTDQDLKVLAIKRQMDSGYALTPQYIKNKGVTAKEMAVVSEHLDELPGVDVTSDWKRDYPYNGLLRTMIG
SISDSNEGLPKSLLDHYLSLGYNRNDRVGKSYLEAEYENVLQGQKEKVKNITNKSGDIVDTEVISEGKSGKDLVLTIDVD
MQKAIEKIVEDELKSAKAKHSAPLLDRAFVVMMDPRNGEVLSIAGKQLKNESGKLKVDDYALGAMTSSYAMGSAVKGATV
LTGLQTGAINLNTTFLDEPLYIGKGKPKKSWASNLGTLGIQGALEKSSNVFMFKTAIALGKGQYKAHQPLDLQTKAFDTF
RYYFSQFGLGVKTGIDLPNEASGYKGSQRLPGFLLDFSIGQYDTYTPLQLAQYVSTIANGGYRMKPQLVKEIREPDSKKG
IGAVTQSVQPEVLNKVDMSDEYIKEVQKGFRRVMTKGTAAGQFASASYKPAGKTGTAQSFYDGPDKSKTGTSTYNTTLVA
YAPYDNPEVAISVVVPWVYNDYGQRYSITNEIGRKVLDKYFELKSKQSKENTVEKNKDKIEKEATE

Sequences:

>Translated_706_residues
MMNKKMKNEKRKSLPIRLNILFLLAFIIFTIVVVRLGMVQIVFGEDYTNEVQKQEEVDVSTSVPRGKIYDRNLNTIVKNK
PMNAITYTRTSSTSQEDRLKIAKKLAEMIKIDTDKITERDKKDYWILTRPKEAEKLITDEDRKKVKDGKLKEDDLYQLQL
DRITEDKLNELTDQDLKVLAIKRQMDSGYALTPQYIKNKGVTAKEMAVVSEHLDELPGVDVTSDWKRDYPYNGLLRTMIG
SISDSNEGLPKSLLDHYLSLGYNRNDRVGKSYLEAEYENVLQGQKEKVKNITNKSGDIVDTEVISEGKSGKDLVLTIDVD
MQKAIEKIVEDELKSAKAKHSAPLLDRAFVVMMDPRNGEVLSIAGKQLKNESGKLKVDDYALGAMTSSYAMGSAVKGATV
LTGLQTGAINLNTTFLDEPLYIGKGKPKKSWASNLGTLGIQGALEKSSNVFMFKTAIALGKGQYKAHQPLDLQTKAFDTF
RYYFSQFGLGVKTGIDLPNEASGYKGSQRLPGFLLDFSIGQYDTYTPLQLAQYVSTIANGGYRMKPQLVKEIREPDSKKG
IGAVTQSVQPEVLNKVDMSDEYIKEVQKGFRRVMTKGTAAGQFASASYKPAGKTGTAQSFYDGPDKSKTGTSTYNTTLVA
YAPYDNPEVAISVVVPWVYNDYGQRYSITNEIGRKVLDKYFELKSKQSKENTVEKNKDKIEKEATE
>Mature_706_residues
MMNKKMKNEKRKSLPIRLNILFLLAFIIFTIVVVRLGMVQIVFGEDYTNEVQKQEEVDVSTSVPRGKIYDRNLNTIVKNK
PMNAITYTRTSSTSQEDRLKIAKKLAEMIKIDTDKITERDKKDYWILTRPKEAEKLITDEDRKKVKDGKLKEDDLYQLQL
DRITEDKLNELTDQDLKVLAIKRQMDSGYALTPQYIKNKGVTAKEMAVVSEHLDELPGVDVTSDWKRDYPYNGLLRTMIG
SISDSNEGLPKSLLDHYLSLGYNRNDRVGKSYLEAEYENVLQGQKEKVKNITNKSGDIVDTEVISEGKSGKDLVLTIDVD
MQKAIEKIVEDELKSAKAKHSAPLLDRAFVVMMDPRNGEVLSIAGKQLKNESGKLKVDDYALGAMTSSYAMGSAVKGATV
LTGLQTGAINLNTTFLDEPLYIGKGKPKKSWASNLGTLGIQGALEKSSNVFMFKTAIALGKGQYKAHQPLDLQTKAFDTF
RYYFSQFGLGVKTGIDLPNEASGYKGSQRLPGFLLDFSIGQYDTYTPLQLAQYVSTIANGGYRMKPQLVKEIREPDSKKG
IGAVTQSVQPEVLNKVDMSDEYIKEVQKGFRRVMTKGTAAGQFASASYKPAGKTGTAQSFYDGPDKSKTGTSTYNTTLVA
YAPYDNPEVAISVVVPWVYNDYGQRYSITNEIGRKVLDKYFELKSKQSKENTVEKNKDKIEKEATE

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=529, Percent_Identity=27.2211720226843, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786272, Length=449, Percent_Identity=25.8351893095768, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79084; Mature: 79084

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKKMKNEKRKSLPIRLNILFLLAFIIFTIVVVRLGMVQIVFGEDYTNEVQKQEEVDVS
CCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCC
TSVPRGKIYDRNLNTIVKNKPMNAITYTRTSSTSQEDRLKIAKKLAEMIKIDTDKITERD
CCCCCCCEECCCCHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHCCC
KKDYWILTRPKEAEKLITDEDRKKVKDGKLKEDDLYQLQLDRITEDKLNELTDQDLKVLA
CCCEEEEECCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHH
IKRQMDSGYALTPQYIKNKGVTAKEMAVVSEHLDELPGVDVTSDWKRDYPYNGLLRTMIG
HHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
SISDSNEGLPKSLLDHYLSLGYNRNDRVGKSYLEAEYENVLQGQKEKVKNITNKSGDIVD
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
TEVISEGKSGKDLVLTIDVDMQKAIEKIVEDELKSAKAKHSAPLLDRAFVVMMDPRNGEV
HHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCE
LSIAGKQLKNESGKLKVDDYALGAMTSSYAMGSAVKGATVLTGLQTGAINLNTTFLDEPL
EEECCHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEECCCCE
YIGKGKPKKSWASNLGTLGIQGALEKSSNVFMFKTAIALGKGQYKAHQPLDLQTKAFDTF
EECCCCCHHHHHHCCCCCCCCHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHHH
RYYFSQFGLGVKTGIDLPNEASGYKGSQRLPGFLLDFSIGQYDTYTPLQLAQYVSTIANG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC
GYRMKPQLVKEIREPDSKKGIGAVTQSVQPEVLNKVDMSDEYIKEVQKGFRRVMTKGTAA
CEEECHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GQFASASYKPAGKTGTAQSFYDGPDKSKTGTSTYNTTLVAYAPYDNPEVAISVVVPWVYN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECHHHC
DYGQRYSITNEIGRKVLDKYFELKSKQSKENTVEKNKDKIEKEATE
CCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNKKMKNEKRKSLPIRLNILFLLAFIIFTIVVVRLGMVQIVFGEDYTNEVQKQEEVDVS
CCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCC
TSVPRGKIYDRNLNTIVKNKPMNAITYTRTSSTSQEDRLKIAKKLAEMIKIDTDKITERD
CCCCCCCEECCCCHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHCCC
KKDYWILTRPKEAEKLITDEDRKKVKDGKLKEDDLYQLQLDRITEDKLNELTDQDLKVLA
CCCEEEEECCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHH
IKRQMDSGYALTPQYIKNKGVTAKEMAVVSEHLDELPGVDVTSDWKRDYPYNGLLRTMIG
HHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
SISDSNEGLPKSLLDHYLSLGYNRNDRVGKSYLEAEYENVLQGQKEKVKNITNKSGDIVD
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
TEVISEGKSGKDLVLTIDVDMQKAIEKIVEDELKSAKAKHSAPLLDRAFVVMMDPRNGEV
HHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCE
LSIAGKQLKNESGKLKVDDYALGAMTSSYAMGSAVKGATVLTGLQTGAINLNTTFLDEPL
EEECCHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEECCCCE
YIGKGKPKKSWASNLGTLGIQGALEKSSNVFMFKTAIALGKGQYKAHQPLDLQTKAFDTF
EECCCCCHHHHHHCCCCCCCCHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHHH
RYYFSQFGLGVKTGIDLPNEASGYKGSQRLPGFLLDFSIGQYDTYTPLQLAQYVSTIANG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC
GYRMKPQLVKEIREPDSKKGIGAVTQSVQPEVLNKVDMSDEYIKEVQKGFRRVMTKGTAA
CEEECHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GQFASASYKPAGKTGTAQSFYDGPDKSKTGTSTYNTTLVAYAPYDNPEVAISVVVPWVYN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECHHHC
DYGQRYSITNEIGRKVLDKYFELKSKQSKENTVEKNKDKIEKEATE
CCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]