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The map label for this gene is accC [H]

Identifier: 52786343

GI number: 52786343

Start: 2524336

End: 2525688

Strand: Reverse

Name: accC [H]

Synonym: BLi02605

Alternate gene names: 52786343

Gene position: 2525688-2524336 (Counterclockwise)

Preceding gene: 52786344

Following gene: 52786342

Centisome position: 59.81

GC content: 49.22

Gene sequence:

>1353_bases
ATGATCAAAAAGCTATTAATTGCGAACAGGGGAGAAATTGCTGTCAGGATTATCAGAGCTTGTAAAGAACTGGGGATTGA
AACGGTAGCCGTCTTTTCCGAGGCCGACAGAGAGGCGCTCCATGTTCAGATGGCTGATGAAGCATTTTGCATCGGACCTA
AGCTTTCAAAAGACAGCTACTTGAATATAACGAACATCGTCAGCGTCGCCAAAATGACCGGTGCTGATGCGATTCACCCC
GGCTACGGCTTCCTGGCAGAAAACGCCGATTTTGCCGAGCTTTGCGAAGAGGTAAATGTAACCTTTGTCGGGCCGACAGC
AGACGCGATTTCCAAGATGGGGACAAAGGATGTTGCAAGGGAAACAATGCAGCAGGCCGGTGTTCCGATCGTACCGGGCT
CCAAAGGAATTATTGAAGATATTGAAGATGCGGTTTCATTGGCCCGCGATATAGGGTATCCTGTCATTATAAAGGCAACT
GCCGGGGGCGGCGGAAAAGGAATCAGGGTCGCCCGGACGGAAGAAGAGCTGATCAACGGCATTAAAATCACTCAGCAGGA
AGCTGCCACCGCTTTCGGCAACCCGGGTGTGTACATTGAAAAATACATTGAAGATTTCAGACACGTCGAAATCCAAGTGC
TTGCAGACACACACGGAAACACGATTCATTTGGGGGAACGCGACTGCTCAATCCAAAGAAGGCTCCAAAAGCTGCTTGAA
GAAACCCCTTCACCTGCTCTGGATGAAGGAATCAGGGAGCAGATGGGGCAGGCCGCTGTCAAAGCGGCTGAAGCCGTGAA
GTACACGGGAGCGGGAACGGTAGAATTTATTTACGATTACCGCGAGCAGAAGTTCTACTTTATGGAAATGAACACGCGCA
TTCAGGTTGAGCATCCGGTGACAGAGATGGTGACGGGCGTTGATTTGATTAAAGAGCAGATCAGAGTGGCGTCAGGCGAA
AAATTAACCCTCACCCAGGATGAAGTCACCTTTAACGGATGGGCAATCGAATGCCGGATTAATGCGGAAAACCCTGAGAA
AAACTTCATGCCTTCTCCGGGAAAAATCGAGATGTATCTGCCTCCGGGAGGGCTCGGCGTCAGAGTGGACTCCGCGGCTT
ATCCGGGATACTCGATTCCCCCTTATTACGACAGCATGATTGCCAAAGTCATCACTTACGGAAAGACGAGGGAAGAAGCT
GTTTCAAGGATGAAAAGAGCGCTGAGCGAATTCGTCATCGAAGGCGTTCATACGACGATACCGTTCCATCTGAAGCTGCT
TGAGCACGAAACATTCGTAAGCGGAGAATTTAATACGAAGTTTTTAGAAATATATGATGTAATGGGGTCGTAA

Upstream 100 bases:

>100_bases
AAGTGAAAGGCGAGATCGTTGAAGTATTAGTTGAAAACGGCCAGCTGGTTGAATACGGACAACCTTTATTTTTAGTAAAA
GCAGAGTAAGGAGCAATAAG

Downstream 100 bases:

>100_bases
TTTTAACGGAGGTGAACATATTGAAAGACGACAACAGCTTATTGGAAATGAGCCATGAAGACAATCATTTGGGAAAAGTG
GAAATCGCTCCGGAAGTGAT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVFSEADREALHVQMADEAFCIGPKLSKDSYLNITNIVSVAKMTGADAIHP
GYGFLAENADFAELCEEVNVTFVGPTADAISKMGTKDVARETMQQAGVPIVPGSKGIIEDIEDAVSLARDIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADTHGNTIHLGERDCSIQRRLQKLLE
ETPSPALDEGIREQMGQAAVKAAEAVKYTGAGTVEFIYDYREQKFYFMEMNTRIQVEHPVTEMVTGVDLIKEQIRVASGE
KLTLTQDEVTFNGWAIECRINAENPEKNFMPSPGKIEMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTREEA
VSRMKRALSEFVIEGVHTTIPFHLKLLEHETFVSGEFNTKFLEIYDVMGS

Sequences:

>Translated_450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVFSEADREALHVQMADEAFCIGPKLSKDSYLNITNIVSVAKMTGADAIHP
GYGFLAENADFAELCEEVNVTFVGPTADAISKMGTKDVARETMQQAGVPIVPGSKGIIEDIEDAVSLARDIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADTHGNTIHLGERDCSIQRRLQKLLE
ETPSPALDEGIREQMGQAAVKAAEAVKYTGAGTVEFIYDYREQKFYFMEMNTRIQVEHPVTEMVTGVDLIKEQIRVASGE
KLTLTQDEVTFNGWAIECRINAENPEKNFMPSPGKIEMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTREEA
VSRMKRALSEFVIEGVHTTIPFHLKLLEHETFVSGEFNTKFLEIYDVMGS
>Mature_450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVFSEADREALHVQMADEAFCIGPKLSKDSYLNITNIVSVAKMTGADAIHP
GYGFLAENADFAELCEEVNVTFVGPTADAISKMGTKDVARETMQQAGVPIVPGSKGIIEDIEDAVSLARDIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADTHGNTIHLGERDCSIQRRLQKLLE
ETPSPALDEGIREQMGQAAVKAAEAVKYTGAGTVEFIYDYREQKFYFMEMNTRIQVEHPVTEMVTGVDLIKEQIRVASGE
KLTLTQDEVTFNGWAIECRINAENPEKNFMPSPGKIEMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTREEA
VSRMKRALSEFVIEGVHTTIPFHLKLLEHETFVSGEFNTKFLEIYDVMGS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=52.1541950113379, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=52.1541950113379, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=52.1541950113379, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=48.8738738738739, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=46.9798657718121, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=46.9798657718121, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=46.9798657718121, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=32.6129666011788, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=32.6129666011788, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=32.6129666011788, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=32.6129666011788, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=32.6129666011788, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.9607843137255, Blast_Score=248, Evalue=8e-66,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=55.8558558558559, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1786216, Length=248, Percent_Identity=25, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=47.6404494382022, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=48.8738738738739, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.5190156599553, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=31.1764705882353, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=31.1764705882353, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=29.4715447154472, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI193204318, Length=417, Percent_Identity=22.5419664268585, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=44.3946188340807, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.6428571428571, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.3125, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.7519379844961, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=457, Percent_Identity=33.4792122538293, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=45.8797327394209, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.427293064877, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=44.7688564476886, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=31.547619047619, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=31.547619047619, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=31.547619047619, Blast_Score=238, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49597; Mature: 49597

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIAVRIIRACKELGIETVAVFSEADREALHVQMADEAFCIGPKLSKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCCEEEHHHHCCCCEEEEEECCCEEEECCCCCCCCC
LNITNIVSVAKMTGADAIHPGYGFLAENADFAELCEEVNVTFVGPTADAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
ETMQQAGVPIVPGSKGIIEDIEDAVSLARDIGYPVIIKATAGGGGKGIRVARTEEELING
HHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADTHGNTIHLGERDCSIQRRLQKLLE
CEEEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ETPSPALDEGIREQMGQAAVKAAEAVKYTGAGTVEFIYDYREQKFYFMEMNTRIQVEHPV
HCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHEEECCCCEEEEEEECCEEEEECCH
TEMVTGVDLIKEQIRVASGEKLTLTQDEVTFNGWAIECRINAENPEKNFMPSPGKIEMYL
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTREEAVSRMKRALSEFVIEGVHTTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PFHLKLLEHETFVSGEFNTKFLEIYDVMGS
CEEEEEEECCEEECCCCCCHHEEEHHHHCC
>Mature Secondary Structure
MIKKLLIANRGEIAVRIIRACKELGIETVAVFSEADREALHVQMADEAFCIGPKLSKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCCEEEHHHHCCCCEEEEEECCCEEEECCCCCCCCC
LNITNIVSVAKMTGADAIHPGYGFLAENADFAELCEEVNVTFVGPTADAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
ETMQQAGVPIVPGSKGIIEDIEDAVSLARDIGYPVIIKATAGGGGKGIRVARTEEELING
HHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADTHGNTIHLGERDCSIQRRLQKLLE
CEEEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ETPSPALDEGIREQMGQAAVKAAEAVKYTGAGTVEFIYDYREQKFYFMEMNTRIQVEHPV
HCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHEEECCCCEEEEEEECCEEEEECCH
TEMVTGVDLIKEQIRVASGEKLTLTQDEVTFNGWAIECRINAENPEKNFMPSPGKIEMYL
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTREEAVSRMKRALSEFVIEGVHTTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PFHLKLLEHETFVSGEFNTKFLEIYDVMGS
CEEEEEEECCEEECCCCCCHHEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]