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The map label for this gene is zwf [H]

Identifier: 52786293

GI number: 52786293

Start: 2473213

End: 2474691

Strand: Direct

Name: zwf [H]

Synonym: BLi02555

Alternate gene names: 52786293

Gene position: 2473213-2474691 (Clockwise)

Preceding gene: 52786290

Following gene: 52786307

Centisome position: 58.57

GC content: 46.38

Gene sequence:

>1479_bases
TTGAAAAAAGATCAAATGGAACCAAAAGCAGTTATCGTAATATTTGGCGCAACAGGGGATTTGGCAAAACGAAAACTATA
TCCTTCTATCCACAGGCTCTACGAAAACGGACAAATCGGGAATGAATTCGCGGTTGTCGGAGTCGGCAGACGCCCTTGGA
CAAATGAAGACTTTCGCAGTACCGTACAGCAATCGGTTTCGAAGTTTCCGTTAAACGAAAAGGATGTGGACGAGTTTACA
TCTCACTTCTACTATCATCCTTTTGATGTTACAAATTCCGGCTCATACCGGGAATTAAACGAACTTATAGAGAAGCTGGA
AAGTACATATGATATTCCGAATAACCGGATGTTTTACTTAGCGATGGCTCCTGAATTTTTCGGAACGATTGCAAAGTTCC
TAAAATCAGAGGGTGTCACTTCAACAACAGGCTGGTCAAGGCTCGTTATCGAAAAGCCTTTCGGGCATGATCTGCCGAGC
GCAAAAGCCTTGAACCAGGAAATCCGTGAAGCTTTTACAGAAGATCAAATTTATCGGATTGACCATTATCTAGGAAAGCA
AATGGTGCAGAACATCGAAGTCATCCGCTTTGCCAACGCGATTTTTGAGCCGCTTTGGACAAACAGATACATCTCGAACA
TTCAAATTACGTCAAGTGAAGATTTGGGTGTGGAAGACAGAGCGAGATATTATGAAAAATCGGGTGCGCTTAGAGACATG
GTGCAAAACCACATTCTTCAAATGGTGGCGCTGCTTGCGATGGAACCGCCGATCAAGCTGAACACGGAAGAGATCCGCAG
CGAAAAAGTGAAGGTTCTCAGAGCCCTTCGTCCGATTCAAAAAGACGATGTCGACCAATTTTTTGTGCGCGGCCAGTATG
ACGCAGGAGTCGTCGACGAAAAACATGTTCCGGCTTATCGCGATGAGCAAAACGTAGCAAAAGATTCGAATACGGAAACG
TTCGTTGCCGGCAAACTGCTGATCGACAACTTCAGATGGGCCGGTGTGCCGTTCTACATCCGGACAGGCAAACGGATGCA
GAAAAAATCAACGCAGATTGTCGTCCAATTTAAAGACATTCCGATGAATCTTTATTACGGAAACGGCAACACGATGCACC
CTAATCTGCTGGTGATTCATATTCAGCCGGATGAAGGCATCACCCTTCATTTAAACGCAAGGAAGCTTGGAGGCGGCACT
TTTGCCCAGCCGATCAAGCTCGACTACTGCCATAACTGCGGGGACGGCATCAACACGCCTGAAGCTTATGAAAAGCTGAT
TTTGGACTGCTTGCACGGAGACGCGACAAACTTTGCCCACTGGGATGAAGTTGCGCTTTCCTGGAGTTTTGTTGATGCGA
TTTCTCAAAACTGGGAGGAAAACAAAACCCTTTCCCCTAACTATAAGGCGGGCTCCATGGGGCCGAAAGCTTCTGACGAC
CTGCTCGCAAAAGACGGCTTTCATTGGTGGCCGCTTTAA

Upstream 100 bases:

>100_bases
GTTTTCATACGATTCGATCTCAAATGTTTGCTTTAAGGGATTATTAGCTTTAAAATGAAGAAAATAAACTTATGCTTCGA
ATAAAGTGAGGTACGTTTAA

Downstream 100 bases:

>100_bases
TAAAAAAACAGCCTTCACAATTGAAGGCTGTTTTTTTATGCTTTCAAGGCCTGCATCTCTTCCGGATGGCTTTTGTCCCG
CTTCCACATCAGCTGAAGGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKKDQMEPKAVIVIFGATGDLAKRKLYPSIHRLYENGQIGNEFAVVGVGRRPWTNEDFRSTVQQSVSKFPLNEKDVDEFT
SHFYYHPFDVTNSGSYRELNELIEKLESTYDIPNNRMFYLAMAPEFFGTIAKFLKSEGVTSTTGWSRLVIEKPFGHDLPS
AKALNQEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSEDLGVEDRARYYEKSGALRDM
VQNHILQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIQKDDVDQFFVRGQYDAGVVDEKHVPAYRDEQNVAKDSNTET
FVAGKLLIDNFRWAGVPFYIRTGKRMQKKSTQIVVQFKDIPMNLYYGNGNTMHPNLLVIHIQPDEGITLHLNARKLGGGT
FAQPIKLDYCHNCGDGINTPEAYEKLILDCLHGDATNFAHWDEVALSWSFVDAISQNWEENKTLSPNYKAGSMGPKASDD
LLAKDGFHWWPL

Sequences:

>Translated_492_residues
MKKDQMEPKAVIVIFGATGDLAKRKLYPSIHRLYENGQIGNEFAVVGVGRRPWTNEDFRSTVQQSVSKFPLNEKDVDEFT
SHFYYHPFDVTNSGSYRELNELIEKLESTYDIPNNRMFYLAMAPEFFGTIAKFLKSEGVTSTTGWSRLVIEKPFGHDLPS
AKALNQEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSEDLGVEDRARYYEKSGALRDM
VQNHILQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIQKDDVDQFFVRGQYDAGVVDEKHVPAYRDEQNVAKDSNTET
FVAGKLLIDNFRWAGVPFYIRTGKRMQKKSTQIVVQFKDIPMNLYYGNGNTMHPNLLVIHIQPDEGITLHLNARKLGGGT
FAQPIKLDYCHNCGDGINTPEAYEKLILDCLHGDATNFAHWDEVALSWSFVDAISQNWEENKTLSPNYKAGSMGPKASDD
LLAKDGFHWWPL
>Mature_492_residues
MKKDQMEPKAVIVIFGATGDLAKRKLYPSIHRLYENGQIGNEFAVVGVGRRPWTNEDFRSTVQQSVSKFPLNEKDVDEFT
SHFYYHPFDVTNSGSYRELNELIEKLESTYDIPNNRMFYLAMAPEFFGTIAKFLKSEGVTSTTGWSRLVIEKPFGHDLPS
AKALNQEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSEDLGVEDRARYYEKSGALRDM
VQNHILQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIQKDDVDQFFVRGQYDAGVVDEKHVPAYRDEQNVAKDSNTET
FVAGKLLIDNFRWAGVPFYIRTGKRMQKKSTQIVVQFKDIPMNLYYGNGNTMHPNLLVIHIQPDEGITLHLNARKLGGGT
FAQPIKLDYCHNCGDGINTPEAYEKLILDCLHGDATNFAHWDEVALSWSFVDAISQNWEENKTLSPNYKAGSMGPKASDD
LLAKDGFHWWPL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=35.7588357588358, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=35.7588357588358, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI52145310, Length=488, Percent_Identity=28.4836065573771, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=38.2293762575453, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538218, Length=494, Percent_Identity=36.2348178137652, Blast_Score=322, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=504, Percent_Identity=37.3015873015873, Blast_Score=308, Evalue=9e-85,
Organism=Drosophila melanogaster, GI24643350, Length=484, Percent_Identity=35.1239669421488, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24643352, Length=484, Percent_Identity=35.1239669421488, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI221513548, Length=487, Percent_Identity=28.1314168377823, Blast_Score=202, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56351; Mature: 56351

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDQMEPKAVIVIFGATGDLAKRKLYPSIHRLYENGQIGNEFAVVGVGRRPWTNEDFRS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
TVQQSVSKFPLNEKDVDEFTSHFYYHPFDVTNSGSYRELNELIEKLESTYDIPNNRMFYL
HHHHHHHHCCCCCCCHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
AMAPEFFGTIAKFLKSEGVTSTTGWSRLVIEKPFGHDLPSAKALNQEIREAFTEDQIYRI
EECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSEDLGVEDRARYYEKSGALRDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHH
VQNHILQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIQKDDVDQFFVRGQYDAGVVDE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
KHVPAYRDEQNVAKDSNTETFVAGKLLIDNFRWAGVPFYIRTGKRMQKKSTQIVVQFKDI
CCCCCCCCCCHHCCCCCCCEEEEEEHEEECCEECCCCEEEECCCHHHCCCCEEEEEEECC
PMNLYYGNGNTMHPNLLVIHIQPDEGITLHLNARKLGGGTFAQPIKLDYCHNCGDGINTP
CEEEEECCCCEECCCEEEEEEECCCCEEEEEECEECCCCCCCCCEEEECCCCCCCCCCCH
EAYEKLILDCLHGDATNFAHWDEVALSWSFVDAISQNWEENKTLSPNYKAGSMGPKASDD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
LLAKDGFHWWPL
HHHCCCCCCCCC
>Mature Secondary Structure
MKKDQMEPKAVIVIFGATGDLAKRKLYPSIHRLYENGQIGNEFAVVGVGRRPWTNEDFRS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
TVQQSVSKFPLNEKDVDEFTSHFYYHPFDVTNSGSYRELNELIEKLESTYDIPNNRMFYL
HHHHHHHHCCCCCCCHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
AMAPEFFGTIAKFLKSEGVTSTTGWSRLVIEKPFGHDLPSAKALNQEIREAFTEDQIYRI
EECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSEDLGVEDRARYYEKSGALRDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHH
VQNHILQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIQKDDVDQFFVRGQYDAGVVDE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
KHVPAYRDEQNVAKDSNTETFVAGKLLIDNFRWAGVPFYIRTGKRMQKKSTQIVVQFKDI
CCCCCCCCCCHHCCCCCCCEEEEEEHEEECCEECCCCEEEECCCHHHCCCCEEEEEEECC
PMNLYYGNGNTMHPNLLVIHIQPDEGITLHLNARKLGGGTFAQPIKLDYCHNCGDGINTP
CEEEEECCCCEECCCEEEEEEECCCCEEEEEECEECCCCCCCCCEEEECCCCCCCCCCCH
EAYEKLILDCLHGDATNFAHWDEVALSWSFVDAISQNWEENKTLSPNYKAGSMGPKASDD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
LLAKDGFHWWPL
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]