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The map label for this gene is nudF [H]

Identifier: 52786251

GI number: 52786251

Start: 2439612

End: 2440178

Strand: Reverse

Name: nudF [H]

Synonym: BLi02512

Alternate gene names: 52786251

Gene position: 2440178-2439612 (Counterclockwise)

Preceding gene: 52786257

Following gene: 52786250

Centisome position: 57.79

GC content: 48.5

Gene sequence:

>567_bases
ATGATCAAACTGAAGCATTTAGAGGAGAAAACCATATCAAAGGAAAAGCTTTTTTCAGGCAAGGTGATCGATCTTTATCT
TGAAGATGTCGAACTGCCGAACGGTAAAACGGGAAAGCGCGAAATCGTGAAGCATCCGGGCGCTGTAGCGGTGCTTGCTT
TAACTGATGAAGAAAACATCATCTTAGTTAAGCAGTACAGAAAAGCGCTTGAACGGACGATCGTTGAAATACCGGCGGGC
AAGCTTGAAAAAGGGGAGAAACCCGAATATACCGCGCTGCGGGAGCTTGAGGAAGAGACGGGATACACGGCGGCGAAGCT
TGAGAAAATCACCGCTTTTTACACATCGCCGGGCTTTGCGGACGAACTGGTGCATCTGTACCTGGCTGAAGAGCTGACGC
CGCTTGAAGAAAAGCGCGAACTTGATGAAGACGAATTTGTTGAAGTACTGGAGGTGCCGCTTTCAGGCGCGCTGAAACTG
ATGGAAACTCAGGACATCTATGATGCGAAAACGGCTTATGCCGTGCAGTATCTGGAGCTGAGAAAGGCCCTGCAAGCAAA
AAAATGA

Upstream 100 bases:

>100_bases
GACGATGCGGTCATTCAGGCGGTAGACCTTCATGGCGCGTCCCCCTTTCATGGTGTATGATAAAATGTATGGGATCTAAA
GCCAGAGCAGAACTTAGGAG

Downstream 100 bases:

>100_bases
AAGAAATATTCGCAGACATGCATATCCATATCGGGCGGACGGAATCAGGCCGGCCCGTTAAGATAACGGCTGCCAGAACG
CTAACGCTCGACGAAATTTT

Product: NudF

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIKLKHLEEKTISKEKLFSGKVIDLYLEDVELPNGKTGKREIVKHPGAVAVLALTDEENIILVKQYRKALERTIVEIPAG
KLEKGEKPEYTALRELEEETGYTAAKLEKITAFYTSPGFADELVHLYLAEELTPLEEKRELDEDEFVEVLEVPLSGALKL
METQDIYDAKTAYAVQYLELRKALQAKK

Sequences:

>Translated_188_residues
MIKLKHLEEKTISKEKLFSGKVIDLYLEDVELPNGKTGKREIVKHPGAVAVLALTDEENIILVKQYRKALERTIVEIPAG
KLEKGEKPEYTALRELEEETGYTAAKLEKITAFYTSPGFADELVHLYLAEELTPLEEKRELDEDEFVEVLEVPLSGALKL
METQDIYDAKTAYAVQYLELRKALQAKK
>Mature_188_residues
MIKLKHLEEKTISKEKLFSGKVIDLYLEDVELPNGKTGKREIVKHPGAVAVLALTDEENIILVKQYRKALERTIVEIPAG
KLEKGEKPEYTALRELEEETGYTAAKLEKITAFYTSPGFADELVHLYLAEELTPLEEKRELDEDEFVEVLEVPLSGALKL
METQDIYDAKTAYAVQYLELRKALQAKK

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI37594464, Length=169, Percent_Identity=34.3195266272189, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1788810, Length=153, Percent_Identity=33.9869281045752, Blast_Score=77, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319587, Length=114, Percent_Identity=34.2105263157895, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 21381; Mature: 21381

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLKHLEEKTISKEKLFSGKVIDLYLEDVELPNGKTGKREIVKHPGAVAVLALTDEENI
CCCCCCHHHHHHHHHHHHCCCEEEEEEECEECCCCCCCCHHHHHCCCCEEEEEEECCCCE
ILVKQYRKALERTIVEIPAGKLEKGEKPEYTALRELEEETGYTAAKLEKITAFYTSPGFA
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCHH
DELVHLYLAEELTPLEEKRELDEDEFVEVLEVPLSGALKLMETQDIYDAKTAYAVQYLEL
HHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKALQAKK
HHHHHCCC
>Mature Secondary Structure
MIKLKHLEEKTISKEKLFSGKVIDLYLEDVELPNGKTGKREIVKHPGAVAVLALTDEENI
CCCCCCHHHHHHHHHHHHCCCEEEEEEECEECCCCCCCCHHHHHCCCCEEEEEEECCCCE
ILVKQYRKALERTIVEIPAGKLEKGEKPEYTALRELEEETGYTAAKLEKITAFYTSPGFA
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCHH
DELVHLYLAEELTPLEEKRELDEDEFVEVLEVPLSGALKLMETQDIYDAKTAYAVQYLEL
HHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKALQAKK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]