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The map label for this gene is serA [H]

Identifier: 52786187

GI number: 52786187

Start: 2382456

End: 2384033

Strand: Direct

Name: serA [H]

Synonym: BLi02446

Alternate gene names: 52786187

Gene position: 2382456-2384033 (Clockwise)

Preceding gene: 52786185

Following gene: 52786208

Centisome position: 56.42

GC content: 48.54

Gene sequence:

>1578_bases
ATGTTTCGAGTATTGGTCTCAGATAAAATGTCCAGCGACGGCCTCAAACCATTAATGGAAGCAGATTTTATTGAAATTGT
AGAAAAGAATGTTGCGGAAGCGGAAGACGAGCTTCATACGTTTGACGCGCTCTTGGTGCGGAGCGCCACGAAGGTAACCG
AAGAGCTGTTTAAAAAGATGACTTCGCTGAAAATCGTCGCCAGAGCAGGTGTCGGCGTCGACAATATCGATATTGACGAG
GCGACAAAACACGGTGTTATCGTCGTAAACGCGCCAAACGGGAATACAATTTCAACCGCTGAACATACCTTTGCAATGTT
TTCAGCGTTAATGAGACATATTCCGCAGGCAAACATCTCCGTGAAATCAAGGGAGTGGAATCGTTCGGCTTACGTCGGTT
CAGAGCTTTACGGAAAAACGCTCGGCATCATCGGAATGGGCCGCATCGGAAGCGAAATCGCGAGCCGCGCAAAAGCATTC
GGTATGACCGTTCATGTATTTGACCCGTTCCTGACCCAAGAAAGGGCAAGCAAGCTCGGCGTTAACGCGAACAGCTTTGA
AGAAGTTCTGGCATGCGCCGACATCATTACGGTTCATACCCCGCTCACGAAAGAAACGAAGGGACTTTTGAACAAAGAAA
CCATCGCAAAAACGAAAAAAGGCGTTCGTCTCGTTAACTGTGCAAGAGGCGGCATCATCGATGAAGCAGCGCTTTTGGAA
GCTCTGGAAAGCGGACATGTCGCTGGCGCTGCCTTGGATGTATTCGAAGTCGAGCCTCCGGTCGATTCAAAACTGATCGA
TCATCCGCTTGTAGTCGCGACTCCTCACTTGGGCGCCTCAACAAAAGAAGCCCAGCTGAATGTCGCTGCACAAGTGTCCG
AAGAAGTCCTTCAGTATGCGCAAGGAAACCCTGTGATGTCCGCGATCAACCTTCCGGCCATGACAAAGGATTCATTCGAA
AAAATCCAGCCTTATCATCAGTTTGCCAATACGATCGGAAACCTTGTGTCTCAGTGCATGAATGAGCCTGTTCAAGATGT
AGCCATCCAATATGAAGGCTCCATCGCCAAACTTGAAACGTCATTTATTACGAAAAGCCTTTTGGCCGGATTTCTGAAGC
CGAGGGTCGCGGCTACCGTTAACGAAGTGAATGCCGGCACCGTTGCGAAAGAGCGCGGCATCAGCTTCAGCGAAAAAATT
TCTTCCAATGAGTCAGGCTATGAAAACTGCATCTCTGTGACTGTCACGGGAGATGTAACAACATTCTCTTTAAGAGCGAC
GTACATTCCGCACTTCGGCGGACGCATCGTTGCCTTAAACGGCTTTGATATTGATTTTTATCCGGCTGGACACCTTGTCT
ACATTCACCACCAGGATAAACCAGGGGCTATCGGCCATGTCGGACGAATTTTAGGAGACCATGACATCAATATCGCCACT
ATGCAGGTAGGCCGAAAAGAAAAAGGCGGAGAAGCGATCATGATGCTTTCCTTTGACCGCCACCTTGAGGACGATATTTT
AGCTGAGCTGAAAAACATCCCGGATATCGTGTCTGTTAAAGCCATCGACCTTCCTTAA

Upstream 100 bases:

>100_bases
TTTTTAATTTTCGTCTTTCCGCGTGAAACTCATTGACACTCTTTATGGAATATGGTAAATTATCAGATATTTATGACGCT
TATTTAGGAGGAAATCTTAC

Downstream 100 bases:

>100_bases
ACAGAAGCTGCGGAACCTGAAAAGAATTCCTTTCAGGTTCCGTTTTTTTTTAGGAATTCTCCCTGATCTCAAGCATCTGG
CGGGGATAAATCCGCTCTCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MFRVLVSDKMSSDGLKPLMEADFIEIVEKNVAEAEDELHTFDALLVRSATKVTEELFKKMTSLKIVARAGVGVDNIDIDE
ATKHGVIVVNAPNGNTISTAEHTFAMFSALMRHIPQANISVKSREWNRSAYVGSELYGKTLGIIGMGRIGSEIASRAKAF
GMTVHVFDPFLTQERASKLGVNANSFEEVLACADIITVHTPLTKETKGLLNKETIAKTKKGVRLVNCARGGIIDEAALLE
ALESGHVAGAALDVFEVEPPVDSKLIDHPLVVATPHLGASTKEAQLNVAAQVSEEVLQYAQGNPVMSAINLPAMTKDSFE
KIQPYHQFANTIGNLVSQCMNEPVQDVAIQYEGSIAKLETSFITKSLLAGFLKPRVAATVNEVNAGTVAKERGISFSEKI
SSNESGYENCISVTVTGDVTTFSLRATYIPHFGGRIVALNGFDIDFYPAGHLVYIHHQDKPGAIGHVGRILGDHDINIAT
MQVGRKEKGGEAIMMLSFDRHLEDDILAELKNIPDIVSVKAIDLP

Sequences:

>Translated_525_residues
MFRVLVSDKMSSDGLKPLMEADFIEIVEKNVAEAEDELHTFDALLVRSATKVTEELFKKMTSLKIVARAGVGVDNIDIDE
ATKHGVIVVNAPNGNTISTAEHTFAMFSALMRHIPQANISVKSREWNRSAYVGSELYGKTLGIIGMGRIGSEIASRAKAF
GMTVHVFDPFLTQERASKLGVNANSFEEVLACADIITVHTPLTKETKGLLNKETIAKTKKGVRLVNCARGGIIDEAALLE
ALESGHVAGAALDVFEVEPPVDSKLIDHPLVVATPHLGASTKEAQLNVAAQVSEEVLQYAQGNPVMSAINLPAMTKDSFE
KIQPYHQFANTIGNLVSQCMNEPVQDVAIQYEGSIAKLETSFITKSLLAGFLKPRVAATVNEVNAGTVAKERGISFSEKI
SSNESGYENCISVTVTGDVTTFSLRATYIPHFGGRIVALNGFDIDFYPAGHLVYIHHQDKPGAIGHVGRILGDHDINIAT
MQVGRKEKGGEAIMMLSFDRHLEDDILAELKNIPDIVSVKAIDLP
>Mature_525_residues
MFRVLVSDKMSSDGLKPLMEADFIEIVEKNVAEAEDELHTFDALLVRSATKVTEELFKKMTSLKIVARAGVGVDNIDIDE
ATKHGVIVVNAPNGNTISTAEHTFAMFSALMRHIPQANISVKSREWNRSAYVGSELYGKTLGIIGMGRIGSEIASRAKAF
GMTVHVFDPFLTQERASKLGVNANSFEEVLACADIITVHTPLTKETKGLLNKETIAKTKKGVRLVNCARGGIIDEAALLE
ALESGHVAGAALDVFEVEPPVDSKLIDHPLVVATPHLGASTKEAQLNVAAQVSEEVLQYAQGNPVMSAINLPAMTKDSFE
KIQPYHQFANTIGNLVSQCMNEPVQDVAIQYEGSIAKLETSFITKSLLAGFLKPRVAATVNEVNAGTVAKERGISFSEKI
SSNESGYENCISVTVTGDVTTFSLRATYIPHFGGRIVALNGFDIDFYPAGHLVYIHHQDKPGAIGHVGRILGDHDINIAT
MQVGRKEKGGEAIMMLSFDRHLEDDILAELKNIPDIVSVKAIDLP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=416, Percent_Identity=41.5865384615385, Blast_Score=329, Evalue=5e-90,
Organism=Homo sapiens, GI4557497, Length=289, Percent_Identity=35.9861591695502, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI61743967, Length=289, Percent_Identity=35.9861591695502, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI145580578, Length=311, Percent_Identity=34.0836012861736, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4557499, Length=311, Percent_Identity=34.0836012861736, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=35.4609929078014, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=32.156862745098, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=32.9192546583851, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI87082289, Length=295, Percent_Identity=32.8813559322034, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=33.195020746888, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=32.319391634981, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=260, Percent_Identity=29.6153846153846, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=48.0263157894737, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI25147481, Length=269, Percent_Identity=31.2267657992565, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320925, Length=316, Percent_Identity=31.0126582278481, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=31.5960912052117, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=267, Percent_Identity=35.2059925093633, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=29.296875, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=36.9127516778523, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=260, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=309, Percent_Identity=47.8964401294498, Blast_Score=276, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=32.4427480916031, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=32.4427480916031, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=32.4427480916031, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=32.4427480916031, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=32.4427480916031, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=30.952380952381, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=34.0579710144928, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585514, Length=321, Percent_Identity=26.4797507788162, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574282, Length=321, Percent_Identity=26.4797507788162, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574284, Length=321, Percent_Identity=26.4797507788162, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45551003, Length=321, Percent_Identity=26.4797507788162, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45552429, Length=321, Percent_Identity=26.4797507788162, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=26.4, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56789; Mature: 56789

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRVLVSDKMSSDGLKPLMEADFIEIVEKNVAEAEDELHTFDALLVRSATKVTEELFKKM
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLKIVARAGVGVDNIDIDEATKHGVIVVNAPNGNTISTAEHTFAMFSALMRHIPQANIS
HHHEEEHHCCCCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCE
VKSREWNRSAYVGSELYGKTLGIIGMGRIGSEIASRAKAFGMTVHVFDPFLTQERASKLG
EECCCCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCC
VNANSFEEVLACADIITVHTPLTKETKGLLNKETIAKTKKGVRLVNCARGGIIDEAALLE
CCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ALESGHVAGAALDVFEVEPPVDSKLIDHPLVVATPHLGASTKEAQLNVAAQVSEEVLQYA
HHHCCCCCEEEEEEEECCCCCCCHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
QGNPVMSAINLPAMTKDSFEKIQPYHQFANTIGNLVSQCMNEPVQDVAIQYEGSIAKLET
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHH
SFITKSLLAGFLKPRVAATVNEVNAGTVAKERGISFSEKISSNESGYENCISVTVTGDVT
HHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCHHHHHCCCCCCCCCEEEEEEECCEE
TFSLRATYIPHFGGRIVALNGFDIDFYPAGHLVYIHHQDKPGAIGHVGRILGDHDINIAT
EEEEEEEECCCCCCEEEEEECCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEE
MQVGRKEKGGEAIMMLSFDRHLEDDILAELKNIPDIVSVKAIDLP
EECCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MFRVLVSDKMSSDGLKPLMEADFIEIVEKNVAEAEDELHTFDALLVRSATKVTEELFKKM
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLKIVARAGVGVDNIDIDEATKHGVIVVNAPNGNTISTAEHTFAMFSALMRHIPQANIS
HHHEEEHHCCCCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCE
VKSREWNRSAYVGSELYGKTLGIIGMGRIGSEIASRAKAFGMTVHVFDPFLTQERASKLG
EECCCCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCC
VNANSFEEVLACADIITVHTPLTKETKGLLNKETIAKTKKGVRLVNCARGGIIDEAALLE
CCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ALESGHVAGAALDVFEVEPPVDSKLIDHPLVVATPHLGASTKEAQLNVAAQVSEEVLQYA
HHHCCCCCEEEEEEEECCCCCCCHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
QGNPVMSAINLPAMTKDSFEKIQPYHQFANTIGNLVSQCMNEPVQDVAIQYEGSIAKLET
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHH
SFITKSLLAGFLKPRVAATVNEVNAGTVAKERGISFSEKISSNESGYENCISVTVTGDVT
HHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCHHHHHCCCCCCCCCEEEEEEECCEE
TFSLRATYIPHFGGRIVALNGFDIDFYPAGHLVYIHHQDKPGAIGHVGRILGDHDINIAT
EEEEEEEECCCCCCEEEEEECCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEE
MQVGRKEKGGEAIMMLSFDRHLEDDILAELKNIPDIVSVKAIDLP
EECCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]