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The map label for this gene is ndk

Identifier: 52786152

GI number: 52786152

Start: 2351982

End: 2352428

Strand: Reverse

Name: ndk

Synonym: BLi02408

Alternate gene names: 52786152

Gene position: 2352428-2351982 (Counterclockwise)

Preceding gene: 52786153

Following gene: 52786151

Centisome position: 55.71

GC content: 45.86

Gene sequence:

>447_bases
ATGGAAAAAACCTTTGTGATGGTAAAACCTGACGGCGTTCAGCGTCAGCTGATCGGCGAAATTTTGTTAAGATTCGAACG
TAAGGGCTTACAATTAATCGGAGCCAAGCTGATGAAGGTCTCAGAAGAGACGGCAGGCGAGCATTATAAAGAACATAACG
GGAAACCGTTTTTCGGCGAACTTGTCGACTTTATTACTTCAGGCCCGGTATTCGCCATGGTATGGGAAGGCGAGGACGCA
ATCGCGGTCGCCAGACAGCTGATCGGGAAGACGAACCCTAAGGAAGCGCTTCCAGGTACAATCCGCGGAGACTTCGGCAT
GTTTGTCGGAAAAAATATCATTCACGGTTCAGATTCTCCTGAAAGTGCAGCACGCGAAATCAACTTGTTTTTTAAAGAGG
ACGAACTTGTTGAAGACGAGAAATTAATGAATCAATGGATTTACTAA

Upstream 100 bases:

>100_bases
TGAATATTCTCCACCCTTTATTGATTAATTGTTTGAAAAATGCTATATTTCTGTTGTAGTGTTGAAAGCCTATACATATT
AGCGGGGTGGAGAATCGACT

Downstream 100 bases:

>100_bases
AAATCAGCTGAAAAGCTGATTTTTTTATATGGAATAGAATGGCTGCCGGCGGGCGGGCTTTTTTCTTTTAAAGATACAAA
TTTAAAAGAAAACAAGCTAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFVMVKPDGVQRQLIGEILLRFERKGLQLIGAKLMKVSEETAGEHYKEHNGKPFFGELVDFITSGPVFAMVWEGEDA
IAVARQLIGKTNPKEALPGTIRGDFGMFVGKNIIHGSDSPESAAREINLFFKEDELVEDEKLMNQWIY

Sequences:

>Translated_148_residues
MEKTFVMVKPDGVQRQLIGEILLRFERKGLQLIGAKLMKVSEETAGEHYKEHNGKPFFGELVDFITSGPVFAMVWEGEDA
IAVARQLIGKTNPKEALPGTIRGDFGMFVGKNIIHGSDSPESAAREINLFFKEDELVEDEKLMNQWIY
>Mature_148_residues
MEKTFVMVKPDGVQRQLIGEILLRFERKGLQLIGAKLMKVSEETAGEHYKEHNGKPFFGELVDFITSGPVFAMVWEGEDA
IAVARQLIGKTNPKEALPGTIRGDFGMFVGKNIIHGSDSPESAAREINLFFKEDELVEDEKLMNQWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=58.5034013605442, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=53.3783783783784, Blast_Score=172, Evalue=1e-43,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=53.3783783783784, Blast_Score=171, Evalue=2e-43,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=4e-43,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=4e-43,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=4e-43,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=4e-43,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=5e-43,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=50.3649635036496, Blast_Score=159, Evalue=6e-40,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=38.3458646616541, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=38.3458646616541, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI5031951, Length=143, Percent_Identity=34.965034965035, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=33.5766423357664, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=48.1751824817518, Blast_Score=140, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=45.945945945946, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=54.421768707483, Blast_Score=177, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=53.0612244897959, Blast_Score=169, Evalue=7e-43,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=31.6176470588235, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_BACLD (Q65I26)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079573.1
- RefSeq:   YP_091981.1
- ProteinModelPortal:   Q65I26
- SMR:   Q65I26
- STRING:   Q65I26
- EnsemblBacteria:   EBBACT00000054689
- EnsemblBacteria:   EBBACT00000059643
- GeneID:   3029513
- GeneID:   3099570
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02408
- KEGG:   bli:BL02781
- NMPDR:   fig|279010.5.peg.259
- eggNOG:   COG0105
- GeneTree:   EBGT00050000001953
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   BLIC279010-1:BLI02408-MONOMER
- BioCyc:   BLIC279010:BL02781-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16687; Mature: 16687

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFVMVKPDGVQRQLIGEILLRFERKGLQLIGAKLMKVSEETAGEHYKEHNGKPFFGE
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LVDFITSGPVFAMVWEGEDAIAVARQLIGKTNPKEALPGTIRGDFGMFVGKNIIHGSDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHCCEEECCCCCH
ESAAREINLFFKEDELVEDEKLMNQWIY
HHHHHHHHHEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKTFVMVKPDGVQRQLIGEILLRFERKGLQLIGAKLMKVSEETAGEHYKEHNGKPFFGE
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LVDFITSGPVFAMVWEGEDAIAVARQLIGKTNPKEALPGTIRGDFGMFVGKNIIHGSDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHCCEEECCCCCH
ESAAREINLFFKEDELVEDEKLMNQWIY
HHHHHHHHHEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA