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The map label for this gene is hisC

Identifier: 52786141

GI number: 52786141

Start: 2341101

End: 2342186

Strand: Reverse

Name: hisC

Synonym: BLi02397

Alternate gene names: 52786141

Gene position: 2342186-2341101 (Counterclockwise)

Preceding gene: 52786142

Following gene: 52786140

Centisome position: 55.47

GC content: 49.36

Gene sequence:

>1086_bases
ATGTTGCAAATTAAAGAACAGTTAAAACAATTAACGCCTTACCAGCCGGGCAAACCGATTGAAGAGGTCAAAAAAGAGTT
CAACCTCGACCGGGTCGTCAAGCTCGCTTCAAATGAGAATCCTTACGGCTGTTCAGAAGCGGCAAAGGAAGCCCTCCAGA
TTGAGGTGCAGCAAATGGCTCTCTATCCTGACGGCTATAGTGCGGCATTGAGAACAAAGCTTGCCTCCCATCTCGGCGTA
AATGAAACGAACATCATCCTGGGAAACGGAACGGACGAAGTCATTCAAATTATTTCCCGTTCTTTGTTGGACCCTGCCTC
AAACACTGTAATGGCGAATCCGACATTTTCACAATACAAGCACAACGCTGTCATCGAAGGAGCGGAAGTCAGAGAAGTCG
GCCTGCTCGAAAACGGCTGCCACGACCTTGATGCAATGCTGAAGGCGATCGATGAACAGACGAAGGTTGTCTGGGTTTGC
AGCCCGAACAATCCGACCGGAACGTATGAATCCGGCCGCAACTTGATCCGTTTCCTTGAAAAAGTGCCGGAACATGTCCT
TGCTGTCGTTGATGAAGCTTATTACGAATACGTAACGGCTGAAGACTACCCCGAGACCATCCCGCTTCTGGAGCGCTTTC
CGAACCTGATGATTCTCAGGACGTTCTCAAAAGCCTACGGTTTGGCGTCTTTAAGGGTGGGCTACGGGATTGCTTCTGAA
CAGCTGATTCAGGCGATTGAGCCGGCGAGACAGCCGTTTAATACAAACCGGCTCGGCCAGGCGGCCGCGCTTGCCGCCCT
CGGCGATCAGGCATTTATCCACGACTGTGTGAGAAAAAACAATGAAGGGCTCAAACAGTACTACGATTTCTGTGATGAGC
ACGGGCTAAATTACTATCCTTCACAAACGAACTTTGTGCTGATTGATTTTAAACGGGATGCAGACGAACTTTTCTCAGAG
CTGCTGAAAAAAGGCTATATCGTCAGATCCGGGAATGCGCTCGGCTTTCCGACGTTCCTTAGAATATCGGTCGGTACGAA
GGAACAGAACGAAGGCTTTTTGAAAACGTTAGCCGGCATGTTGTAA

Upstream 100 bases:

>100_bases
CGAACTCGTCGCCCCTGAGACAAGGGAACAAGCCTTAAAGGCGTTTGAGGCATACGCTAAGACATTTAGCGGATCGTACA
TGGTAAAATGAGGTGACAGA

Downstream 100 bases:

>100_bases
GAGGTGATGATTCAGTCACCTCTTTAGTCTATTGATGAACTAGGTGATAAAAAATGACTCAACCGAATGAAACGATTTTG
TTGGCCGGTTTGGGCTTAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLQIKEQLKQLTPYQPGKPIEEVKKEFNLDRVVKLASNENPYGCSEAAKEALQIEVQQMALYPDGYSAALRTKLASHLGV
NETNIILGNGTDEVIQIISRSLLDPASNTVMANPTFSQYKHNAVIEGAEVREVGLLENGCHDLDAMLKAIDEQTKVVWVC
SPNNPTGTYESGRNLIRFLEKVPEHVLAVVDEAYYEYVTAEDYPETIPLLERFPNLMILRTFSKAYGLASLRVGYGIASE
QLIQAIEPARQPFNTNRLGQAAALAALGDQAFIHDCVRKNNEGLKQYYDFCDEHGLNYYPSQTNFVLIDFKRDADELFSE
LLKKGYIVRSGNALGFPTFLRISVGTKEQNEGFLKTLAGML

Sequences:

>Translated_361_residues
MLQIKEQLKQLTPYQPGKPIEEVKKEFNLDRVVKLASNENPYGCSEAAKEALQIEVQQMALYPDGYSAALRTKLASHLGV
NETNIILGNGTDEVIQIISRSLLDPASNTVMANPTFSQYKHNAVIEGAEVREVGLLENGCHDLDAMLKAIDEQTKVVWVC
SPNNPTGTYESGRNLIRFLEKVPEHVLAVVDEAYYEYVTAEDYPETIPLLERFPNLMILRTFSKAYGLASLRVGYGIASE
QLIQAIEPARQPFNTNRLGQAAALAALGDQAFIHDCVRKNNEGLKQYYDFCDEHGLNYYPSQTNFVLIDFKRDADELFSE
LLKKGYIVRSGNALGFPTFLRISVGTKEQNEGFLKTLAGML
>Mature_361_residues
MLQIKEQLKQLTPYQPGKPIEEVKKEFNLDRVVKLASNENPYGCSEAAKEALQIEVQQMALYPDGYSAALRTKLASHLGV
NETNIILGNGTDEVIQIISRSLLDPASNTVMANPTFSQYKHNAVIEGAEVREVGLLENGCHDLDAMLKAIDEQTKVVWVC
SPNNPTGTYESGRNLIRFLEKVPEHVLAVVDEAYYEYVTAEDYPETIPLLERFPNLMILRTFSKAYGLASLRVGYGIASE
QLIQAIEPARQPFNTNRLGQAAALAALGDQAFIHDCVRKNNEGLKQYYDFCDEHGLNYYPSQTNFVLIDFKRDADELFSE
LLKKGYIVRSGNALGFPTFLRISVGTKEQNEGFLKTLAGML

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=362, Percent_Identity=29.5580110497238, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=29.023746701847, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BACLD (Q65I37)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079561.1
- RefSeq:   YP_091970.1
- ProteinModelPortal:   Q65I37
- SMR:   Q65I37
- STRING:   Q65I37
- EnsemblBacteria:   EBBACT00000057444
- EnsemblBacteria:   EBBACT00000058869
- GeneID:   3027688
- GeneID:   3099452
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02397
- KEGG:   bli:BL02769
- NMPDR:   fig|279010.5.peg.247
- eggNOG:   COG0079
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- ProtClustDB:   PRK03158
- BioCyc:   BLIC279010-1:BLI02397-MONOMER
- BioCyc:   BLIC279010:BL02769-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40337; Mature: 40337

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQIKEQLKQLTPYQPGKPIEEVKKEFNLDRVVKLASNENPYGCSEAAKEALQIEVQQMA
CCCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LYPDGYSAALRTKLASHLGVNETNIILGNGTDEVIQIISRSLLDPASNTVMANPTFSQYK
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCHHHHC
HNAVIEGAEVREVGLLENGCHDLDAMLKAIDEQTKVVWVCSPNNPTGTYESGRNLIRFLE
CCCEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
KVPEHVLAVVDEAYYEYVTAEDYPETIPLLERFPNLMILRTFSKAYGLASLRVGYGIASE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEHHHHHHHHCCHHHHHCCCCCHH
QLIQAIEPARQPFNTNRLGQAAALAALGDQAFIHDCVRKNNEGLKQYYDFCDEHGLNYYP
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
SQTNFVLIDFKRDADELFSELLKKGYIVRSGNALGFPTFLRISVGTKEQNEGFLKTLAGM
CCCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHC
L
C
>Mature Secondary Structure
MLQIKEQLKQLTPYQPGKPIEEVKKEFNLDRVVKLASNENPYGCSEAAKEALQIEVQQMA
CCCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LYPDGYSAALRTKLASHLGVNETNIILGNGTDEVIQIISRSLLDPASNTVMANPTFSQYK
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCHHHHC
HNAVIEGAEVREVGLLENGCHDLDAMLKAIDEQTKVVWVCSPNNPTGTYESGRNLIRFLE
CCCEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
KVPEHVLAVVDEAYYEYVTAEDYPETIPLLERFPNLMILRTFSKAYGLASLRVGYGIASE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEHHHHHHHHCCHHHHHCCCCCHH
QLIQAIEPARQPFNTNRLGQAAALAALGDQAFIHDCVRKNNEGLKQYYDFCDEHGLNYYP
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
SQTNFVLIDFKRDADELFSELLKKGYIVRSGNALGFPTFLRISVGTKEQNEGFLKTLAGM
CCCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA