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The map label for this gene is metA

Identifier: 52786073

GI number: 52786073

Start: 2279461

End: 2280369

Strand: Direct

Name: metA

Synonym: BLi02329

Alternate gene names: 52786073

Gene position: 2279461-2280369 (Clockwise)

Preceding gene: 52786061

Following gene: 52786074

Centisome position: 53.98

GC content: 42.79

Gene sequence:

>909_bases
TTGCCTATCAACATACCTATCAATTTGCCAGCAAAGCAGATTCTTGAAAGTGAAAATATTTTTGTCATGGATGAAAAACG
GGCTTTTCATCAGGACATCAGACCTTTAAATATTGTGATTCTTAATCTGATGCCGCAGAAAATCAAGACCGAGACACAGC
TGCTCAGGATGCTCGGGAATTCTCCTTTACAGGTATATTTCACTTTTTTAATACCGTCTACACACACGCCAAAACATACA
CCAAGGCAGCATTTGGAACAGTTTTATACAACTTTTTCTTCAATCAGGGACCGAAAATTCGACGGCATGATTATTACCGG
TGCGCCGATCGAGCATTTGGAGTACGAAGAGGTATCCTATTGGGAAGAACTCCGGGAGATTTTAGACTGGAGCAAAACGC
ATGTCACGTCAACGCTTCACATCTGCTGGGGAGCGCAGGCGGGACTGTATCATCACTACGGCATTCGCAAAGTCAAACTG
CCGAAAAAGACATTTGGCGTTTTTGAACACAGAATAATGGAGAAAAATGAAAGACTGGTCAGAGGCTTTGAAGAGTTCTA
CTATGTCCCGCACTCCAGGCATACAGATATCAATATGGATGACCTTAAAGCCGTTTCCCATTTAAAAGTGCTCAGCATAT
CCGATGAAGCGGGCGTCTGTTTAATTGCTTCAAAGGATGAAAAACAAGTTTTTTTAACTGGACATCCTGAGTATGATACA
GATACTCTTAAAGAAGAGTATGAAAGGGATTTAGCCAGGAACATGGAGATTGATCCGCCGGTGAATTATTTTAAAGAAGG
GCCGGATGGCGCGGTACCTGTAAACCGCTGGAAAGCCCATGCGACTCTTTTGTTCATGAATTGGCTGAACTACTACGTTT
ACCAGGAAACGCCGTATGAGTGGAAATGA

Upstream 100 bases:

>100_bases
TCACACACTTCTTTTATTGTAACACAATTCACACATTGAAATATCGCCAAAAAGTTCCTATAATGAAGAAAAATCAGCGG
AGAAAACCGGAGGTGGCGTG

Downstream 100 bases:

>100_bases
AATTCTCATGCCCTGGTCTGATGCAAGACATTCAAAATGTGTTAAAATACAGTTGGGTTAGTCTTCCACAATGGGGATTC
GGCTTTGCCGCGAAAGCGGG

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPINIPINLPAKQILESENIFVMDEKRAFHQDIRPLNIVILNLMPQKIKTETQLLRMLGNSPLQVYFTFLIPSTHTPKHT
PRQHLEQFYTTFSSIRDRKFDGMIITGAPIEHLEYEEVSYWEELREILDWSKTHVTSTLHICWGAQAGLYHHYGIRKVKL
PKKTFGVFEHRIMEKNERLVRGFEEFYYVPHSRHTDINMDDLKAVSHLKVLSISDEAGVCLIASKDEKQVFLTGHPEYDT
DTLKEEYERDLARNMEIDPPVNYFKEGPDGAVPVNRWKAHATLLFMNWLNYYVYQETPYEWK

Sequences:

>Translated_302_residues
MPINIPINLPAKQILESENIFVMDEKRAFHQDIRPLNIVILNLMPQKIKTETQLLRMLGNSPLQVYFTFLIPSTHTPKHT
PRQHLEQFYTTFSSIRDRKFDGMIITGAPIEHLEYEEVSYWEELREILDWSKTHVTSTLHICWGAQAGLYHHYGIRKVKL
PKKTFGVFEHRIMEKNERLVRGFEEFYYVPHSRHTDINMDDLKAVSHLKVLSISDEAGVCLIASKDEKQVFLTGHPEYDT
DTLKEEYERDLARNMEIDPPVNYFKEGPDGAVPVNRWKAHATLLFMNWLNYYVYQETPYEWK
>Mature_301_residues
PINIPINLPAKQILESENIFVMDEKRAFHQDIRPLNIVILNLMPQKIKTETQLLRMLGNSPLQVYFTFLIPSTHTPKHTP
RQHLEQFYTTFSSIRDRKFDGMIITGAPIEHLEYEEVSYWEELREILDWSKTHVTSTLHICWGAQAGLYHHYGIRKVKLP
KKTFGVFEHRIMEKNERLVRGFEEFYYVPHSRHTDINMDDLKAVSHLKVLSISDEAGVCLIASKDEKQVFLTGHPEYDTD
TLKEEYERDLARNMEIDPPVNYFKEGPDGAVPVNRWKAHATLLFMNWLNYYVYQETPYEWK

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=302, Percent_Identity=46.3576158940397, Blast_Score=300, Evalue=9e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_BACLD (Q65IA5)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079491.1
- RefSeq:   YP_091902.1
- HSSP:   Q72X44
- ProteinModelPortal:   Q65IA5
- SMR:   Q65IA5
- STRING:   Q65IA5
- EnsemblBacteria:   EBBACT00000055098
- EnsemblBacteria:   EBBACT00000058846
- GeneID:   3029118
- GeneID:   3100162
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02329
- KEGG:   bli:BL01365
- NMPDR:   fig|279010.5.peg.180
- eggNOG:   COG1897
- GeneTree:   EBGT00050000001387
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- BioCyc:   BLIC279010-1:BLI02329-MONOMER
- BioCyc:   BLIC279010:BL01365-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35653; Mature: 35522

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPINIPINLPAKQILESENIFVMDEKRAFHQDIRPLNIVILNLMPQKIKTETQLLRMLGN
CCEEECCCCCHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCC
SPLQVYFTFLIPSTHTPKHTPRQHLEQFYTTFSSIRDRKFDGMIITGAPIEHLEYEEVSY
CCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHCCHHHHHH
WEELREILDWSKTHVTSTLHICWGAQAGLYHHYGIRKVKLPKKTFGVFEHRIMEKNERLV
HHHHHHHHCCHHHHHHEEEEEEECCCCCCEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
RGFEEFYYVPHSRHTDINMDDLKAVSHLKVLSISDEAGVCLIASKDEKQVFLTGHPEYDT
HHHHHHEECCCCCCCCCCHHHHHHHHHEEEEEECCCCCEEEEECCCCCEEEEECCCCCCH
DTLKEEYERDLARNMEIDPPVNYFKEGPDGAVPVNRWKAHATLLFMNWLNYYVYQETPYE
HHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCC
WK
CC
>Mature Secondary Structure 
PINIPINLPAKQILESENIFVMDEKRAFHQDIRPLNIVILNLMPQKIKTETQLLRMLGN
CEEECCCCCHHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCC
SPLQVYFTFLIPSTHTPKHTPRQHLEQFYTTFSSIRDRKFDGMIITGAPIEHLEYEEVSY
CCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHCCHHHHHH
WEELREILDWSKTHVTSTLHICWGAQAGLYHHYGIRKVKLPKKTFGVFEHRIMEKNERLV
HHHHHHHHCCHHHHHHEEEEEEECCCCCCEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
RGFEEFYYVPHSRHTDINMDDLKAVSHLKVLSISDEAGVCLIASKDEKQVFLTGHPEYDT
HHHHHHEECCCCCCCCCCHHHHHHHHHEEEEEECCCCCEEEEECCCCCEEEEECCCCCCH
DTLKEEYERDLARNMEIDPPVNYFKEGPDGAVPVNRWKAHATLLFMNWLNYYVYQETPYE
HHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCC
WK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA