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The map label for this gene is fhs

Identifier: 52786072

GI number: 52786072

Start: 2277630

End: 2279309

Strand: Reverse

Name: fhs

Synonym: BLi02328

Alternate gene names: 52786072

Gene position: 2279309-2277630 (Counterclockwise)

Preceding gene: 52786075

Following gene: 52786071

Centisome position: 53.98

GC content: 50.77

Gene sequence:

>1680_bases
ATGAAATCCCATTTATCAGACATAGAAATCGCACAAAGAACGGAATTAAAACCGATTACCGAAATTGCACGGAAACTCAA
TATAAATGACGAAGAAATAGAGTGTTTTGGTTGCACAAAAGCGAAAATTTCTTTGAAAATTTTTGAGCGTTTGAAAGAAA
AACCCGATGGCCAGGTGATTTTGGTAACCTCCATCAACCCGACACCGGCCGGCGAAGGGAAGTCGACTGTCACCGTCGGA
TTGAGCCAGGCGCTCTGGCAGATTGGCAAAAAATCGATCGTGGCGATGAGGGAGCCTTCACTCGGTCCGACAATGGGCTT
GAAAGGCGGGGCTGCCGGAGGAGGGTATTCCCAGGTTCTTCCGATGGAGGACATCAACCTTCACTTTACGGGAGATATGC
ATGCGATCACAGCTGCAAACAACGCTTTGGCGGCTTTCATAGACAATCATATTCATCAGGGAAACGAATTAAACATCGAT
ATCAGAAAAATCGTCTGGAAAAGGGCGCTTGATCTCAATGACAGGGCGCTGCGTGAAACCGTTGTCGGCCTGGGCGGAAA
AGCGAACGGATTTCCCAGGGAAGACGGCTTTGACATTACTGTCGCTTCGGAAATCATGGCCGTTTTATGCCTGGCCAGAG
ACTTGGCCGATTTAAAAAAGCGCCTGGCTTCGATGATCGTCGCCTACACAGTCGACGGACAGCCGGTAACGGCCGGCATG
CTCGGTGTGCAGGGAGCGCTTGCCCTCCTGTTAAAAGATGCTATCAAACCAAACCTTGTTCAGACTGTTGAAGGAACACC
GGCGCTCGTCCACGGAGGACCGTTTGCAAACATCGCCCACGGGGCAAACAGTCTGATCGCGACAAAAACGGCTGCGAAGC
TGGCTGACTATGTCGTGACTGAAGCGGGATTTGGCGCTGATTTGGGGGCGGAAAAATTCATGCACATCAAAACGAGAGCC
GGCGGGTTCACACCGGGGGCGGTCGTGATCGTCGCCACCGTCAGAGCGCTGAAAATGCATGGCGGAACGCCTCTCGCCGA
TTTGAAGCAAAAAGACCTGGAAGCATTAAAAAGGGGAATTGCCAACCTTGCGAAGCATATCGAAACGATAGATGCCTTCG
GTCTTCCATACGTTGTGGCTGTCAACAGATTCGTACAGGACACGGAGGACGAGCTTGAGGCCGTTCTTGGCTGGTGCAGA
GACAACGGACATCCGGCTGCACTTTGCAATGTTTGGGAAGAGGGCGGAAAAGGCGGGACTGATCTCGCAAGGGAAGTCAT
TCATGTCATGGAGCAAAAAGACAACAGGTTTTCCTATTTATACGAATTAACCGACTCGATCGAAGACAAATTAGCCAAGA
TCTCCCGCACCGTTTATGGCGCCGAAGGGGTAGAGTTTACCGAAAAGGCGAAAAAACAGCTGCTTGAATTGAAAAAGAAC
GGGTTGGACGGACTGCCTGTCTGCGTGGCGAAAACTCAGTATTCTTTATCAGATGACCCGGGTAAAATCGGCAGGCCGCA
AGATTTTAGCATCACCGTCCGCGAATTAAAACCATCGAGGGGCGCGGGATTTATCGTCGCTTTGACAGGCAGTATTTTAA
CAATGCCGGGGCTGCCGAAACACCCTGCCGCGCTTAAGATGGATGTCGACGAAAGCGGCAGAGCCAAAGGTTTATTCTAA

Upstream 100 bases:

>100_bases
TGGCGATATTTCAATGTGTGAATTGTGTTACAATAAAAGAAGTGTGTGAAAAATATGGAAAATCATCGTGTGATGAACCA
AAAGGAGGCTCCTCTTGCAA

Downstream 100 bases:

>100_bases
AAAGGAGGGACCGTCATGTCCATTTACGATATCAGCGTCAAGACGATTAAAGGCGAGGACACGACACTGCGGCCGTATAA
AGGCAAAGTGCTGCTCATCG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MKSHLSDIEIAQRTELKPITEIARKLNINDEEIECFGCTKAKISLKIFERLKEKPDGQVILVTSINPTPAGEGKSTVTVG
LSQALWQIGKKSIVAMREPSLGPTMGLKGGAAGGGYSQVLPMEDINLHFTGDMHAITAANNALAAFIDNHIHQGNELNID
IRKIVWKRALDLNDRALRETVVGLGGKANGFPREDGFDITVASEIMAVLCLARDLADLKKRLASMIVAYTVDGQPVTAGM
LGVQGALALLLKDAIKPNLVQTVEGTPALVHGGPFANIAHGANSLIATKTAAKLADYVVTEAGFGADLGAEKFMHIKTRA
GGFTPGAVVIVATVRALKMHGGTPLADLKQKDLEALKRGIANLAKHIETIDAFGLPYVVAVNRFVQDTEDELEAVLGWCR
DNGHPAALCNVWEEGGKGGTDLAREVIHVMEQKDNRFSYLYELTDSIEDKLAKISRTVYGAEGVEFTEKAKKQLLELKKN
GLDGLPVCVAKTQYSLSDDPGKIGRPQDFSITVRELKPSRGAGFIVALTGSILTMPGLPKHPAALKMDVDESGRAKGLF

Sequences:

>Translated_559_residues
MKSHLSDIEIAQRTELKPITEIARKLNINDEEIECFGCTKAKISLKIFERLKEKPDGQVILVTSINPTPAGEGKSTVTVG
LSQALWQIGKKSIVAMREPSLGPTMGLKGGAAGGGYSQVLPMEDINLHFTGDMHAITAANNALAAFIDNHIHQGNELNID
IRKIVWKRALDLNDRALRETVVGLGGKANGFPREDGFDITVASEIMAVLCLARDLADLKKRLASMIVAYTVDGQPVTAGM
LGVQGALALLLKDAIKPNLVQTVEGTPALVHGGPFANIAHGANSLIATKTAAKLADYVVTEAGFGADLGAEKFMHIKTRA
GGFTPGAVVIVATVRALKMHGGTPLADLKQKDLEALKRGIANLAKHIETIDAFGLPYVVAVNRFVQDTEDELEAVLGWCR
DNGHPAALCNVWEEGGKGGTDLAREVIHVMEQKDNRFSYLYELTDSIEDKLAKISRTVYGAEGVEFTEKAKKQLLELKKN
GLDGLPVCVAKTQYSLSDDPGKIGRPQDFSITVRELKPSRGAGFIVALTGSILTMPGLPKHPAALKMDVDESGRAKGLF
>Mature_559_residues
MKSHLSDIEIAQRTELKPITEIARKLNINDEEIECFGCTKAKISLKIFERLKEKPDGQVILVTSINPTPAGEGKSTVTVG
LSQALWQIGKKSIVAMREPSLGPTMGLKGGAAGGGYSQVLPMEDINLHFTGDMHAITAANNALAAFIDNHIHQGNELNID
IRKIVWKRALDLNDRALRETVVGLGGKANGFPREDGFDITVASEIMAVLCLARDLADLKKRLASMIVAYTVDGQPVTAGM
LGVQGALALLLKDAIKPNLVQTVEGTPALVHGGPFANIAHGANSLIATKTAAKLADYVVTEAGFGADLGAEKFMHIKTRA
GGFTPGAVVIVATVRALKMHGGTPLADLKQKDLEALKRGIANLAKHIETIDAFGLPYVVAVNRFVQDTEDELEAVLGWCR
DNGHPAALCNVWEEGGKGGTDLAREVIHVMEQKDNRFSYLYELTDSIEDKLAKISRTVYGAEGVEFTEKAKKQLLELKKN
GLDGLPVCVAKTQYSLSDDPGKIGRPQDFSITVRELKPSRGAGFIVALTGSILTMPGLPKHPAALKMDVDESGRAKGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=45.3957996768982, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=45.718901453958, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=40, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=612, Percent_Identity=44.4444444444444, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17568739, Length=612, Percent_Identity=44.4444444444444, Blast_Score=466, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.7892234548336, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321643, Length=628, Percent_Identity=44.1082802547771, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=44.1033925686591, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=44.1033925686591, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=44.1033925686591, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=44.1033925686591, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_BACLD (Q65IA6)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079490.1
- RefSeq:   YP_091901.1
- ProteinModelPortal:   Q65IA6
- SMR:   Q65IA6
- STRING:   Q65IA6
- EnsemblBacteria:   EBBACT00000056774
- EnsemblBacteria:   EBBACT00000060525
- GeneID:   3028622
- GeneID:   3100294
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02328
- KEGG:   bli:BL01370
- NMPDR:   fig|279010.5.peg.179
- eggNOG:   COG2759
- GeneTree:   EBGT00050000004414
- HOGENOM:   HBG677721
- ProtClustDB:   PRK13505
- BioCyc:   BLIC279010-1:BLI02328-MONOMER
- BioCyc:   BLIC279010:BL01370-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59962; Mature: 59962

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHLSDIEIAQRTELKPITEIARKLNINDEEIECFGCTKAKISLKIFERLKEKPDGQVI
CCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEE
LVTSINPTPAGEGKSTVTVGLSQALWQIGKKSIVAMREPSLGPTMGLKGGAAGGGYSQVL
EEEECCCCCCCCCCCEEEECHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCC
PMEDINLHFTGDMHAITAANNALAAFIDNHIHQGNELNIDIRKIVWKRALDLNDRALRET
CCCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
VVGLGGKANGFPREDGFDITVASEIMAVLCLARDLADLKKRLASMIVAYTVDGQPVTAGM
HHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHH
LGVQGALALLLKDAIKPNLVQTVEGTPALVHGGPFANIAHGANSLIATKTAAKLADYVVT
HHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFMHIKTRAGGFTPGAVVIVATVRALKMHGGTPLADLKQKDLEALKRGI
CCCCCCCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ANLAKHIETIDAFGLPYVVAVNRFVQDTEDELEAVLGWCRDNGHPAALCNVWEEGGKGGT
HHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
DLAREVIHVMEQKDNRFSYLYELTDSIEDKLAKISRTVYGAEGVEFTEKAKKQLLELKKN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GLDGLPVCVAKTQYSLSDDPGKIGRPQDFSITVRELKPSRGAGFIVALTGSILTMPGLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCCCC
HPAALKMDVDESGRAKGLF
CCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKSHLSDIEIAQRTELKPITEIARKLNINDEEIECFGCTKAKISLKIFERLKEKPDGQVI
CCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEE
LVTSINPTPAGEGKSTVTVGLSQALWQIGKKSIVAMREPSLGPTMGLKGGAAGGGYSQVL
EEEECCCCCCCCCCCEEEECHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCC
PMEDINLHFTGDMHAITAANNALAAFIDNHIHQGNELNIDIRKIVWKRALDLNDRALRET
CCCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
VVGLGGKANGFPREDGFDITVASEIMAVLCLARDLADLKKRLASMIVAYTVDGQPVTAGM
HHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHH
LGVQGALALLLKDAIKPNLVQTVEGTPALVHGGPFANIAHGANSLIATKTAAKLADYVVT
HHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFMHIKTRAGGFTPGAVVIVATVRALKMHGGTPLADLKQKDLEALKRGI
CCCCCCCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ANLAKHIETIDAFGLPYVVAVNRFVQDTEDELEAVLGWCRDNGHPAALCNVWEEGGKGGT
HHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
DLAREVIHVMEQKDNRFSYLYELTDSIEDKLAKISRTVYGAEGVEFTEKAKKQLLELKKN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GLDGLPVCVAKTQYSLSDDPGKIGRPQDFSITVRELKPSRGAGFIVALTGSILTMPGLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCCCC
HPAALKMDVDESGRAKGLF
CCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA