Click here to switch to the map view.

The map label for this gene is gltC [H]

Identifier: 52785913

GI number: 52785913

Start: 2117231

End: 2118133

Strand: Direct

Name: gltC [H]

Synonym: BLi02163

Alternate gene names: 52785913

Gene position: 2117231-2118133 (Clockwise)

Preceding gene: 52785905

Following gene: 52785915

Centisome position: 50.14

GC content: 47.4

Gene sequence:

>903_bases
ATGGAATTACGCCAATTGCATTACTTTATGGAAGTTGCGGAAAGAGAGCATGTATCGGAAGCGGCCATGCACCTTCATGT
CGCTCAGTCGGCGATCAGCAGGCAGATCGCCAATCTAGAGGAAGAGCTCGGCGTTGATTTGTTTGAGCGCGAAGGCCGGA
ATGTGAAGCTGACTCCGATTGGGAGGCAGTTTTTAGACCATATTAAAACGGCGATGAAAGCGATCGATTTTGCGAAGGAA
CAAATCGACGAGTATTTGGACCCGAATCGCGGGACCGTTAAAATCGGTTTCCCGACAAGCCTTGCGGGCCAGTTCCTCCC
GACCGTCATTTCCGCTTTTAAAGAGGAGCATCCTAATGTCGCTTTTCTTTTAAGACAGGGATCTTATAAATTTTTAATCG
AAGCGGTGAAAAACAGGGATATCGATTTGGCTTTTCTCGGTCCCGTCCCGTCAAACATTGCCGAGATTAAAGGAGACATT
TTGTTTTCGGAGAGCCTTCTGGCGCTCGTGCCGGTCAATCATCCGTTGTCAGGCCAGAAAAGTCTTCATCTCGGCGATCT
CAGAAATGATCAGTATGTGCTGTTTCCTGACGGGTACATTCTCCGAAAAATGGCTGTTGACGCATGCAAGCAAGTCGGAT
ATACGCCTAAAATTTCCTCGGAGGGCGAAGATTTGGATGCGATCAAAGGGCTTGTTTCTGCTGATATGGGGGTGACGCTT
TTGCCGGAAAGCGCCTTTAATGAAACGGCACCCCGTTTTACAAAGAAGATTCCGATTGATTATCCGCAGGTAAAGCGCAC
GGTCGGGATCATCACCCCTAAAAACAGGGAGCTTTCCCCTTCTGCAAAAGTCTTTTATCAGTTCGTAAAGAAGTTTTTTT
CTCGCCTTCAGCAATATCAATAA

Upstream 100 bases:

>100_bases
CTTACAAACTCTAATCCTATTGTAGGTTTTCAAATCTATACAAACAATATATAATTTAGATTAAAACTATCTCATTTTGA
GATTAGCAGGTGAAACAACG

Downstream 100 bases:

>100_bases
CAGTCTTGCAACGAAATCAGCCGGGCGCAAAAGCTTGGCTGATTTTATTTTATCATAAATAAAGATAAATGTCTGAATTT
TCTGCCCTTTATTGTTTGCG

Product: GltC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MELRQLHYFMEVAEREHVSEAAMHLHVAQSAISRQIANLEEELGVDLFEREGRNVKLTPIGRQFLDHIKTAMKAIDFAKE
QIDEYLDPNRGTVKIGFPTSLAGQFLPTVISAFKEEHPNVAFLLRQGSYKFLIEAVKNRDIDLAFLGPVPSNIAEIKGDI
LFSESLLALVPVNHPLSGQKSLHLGDLRNDQYVLFPDGYILRKMAVDACKQVGYTPKISSEGEDLDAIKGLVSADMGVTL
LPESAFNETAPRFTKKIPIDYPQVKRTVGIITPKNRELSPSAKVFYQFVKKFFSRLQQYQ

Sequences:

>Translated_300_residues
MELRQLHYFMEVAEREHVSEAAMHLHVAQSAISRQIANLEEELGVDLFEREGRNVKLTPIGRQFLDHIKTAMKAIDFAKE
QIDEYLDPNRGTVKIGFPTSLAGQFLPTVISAFKEEHPNVAFLLRQGSYKFLIEAVKNRDIDLAFLGPVPSNIAEIKGDI
LFSESLLALVPVNHPLSGQKSLHLGDLRNDQYVLFPDGYILRKMAVDACKQVGYTPKISSEGEDLDAIKGLVSADMGVTL
LPESAFNETAPRFTKKIPIDYPQVKRTVGIITPKNRELSPSAKVFYQFVKKFFSRLQQYQ
>Mature_300_residues
MELRQLHYFMEVAEREHVSEAAMHLHVAQSAISRQIANLEEELGVDLFEREGRNVKLTPIGRQFLDHIKTAMKAIDFAKE
QIDEYLDPNRGTVKIGFPTSLAGQFLPTVISAFKEEHPNVAFLLRQGSYKFLIEAVKNRDIDLAFLGPVPSNIAEIKGDI
LFSESLLALVPVNHPLSGQKSLHLGDLRNDQYVLFPDGYILRKMAVDACKQVGYTPKISSEGEDLDAIKGLVSADMGVTL
LPESAFNETAPRFTKKIPIDYPQVKRTVGIITPKNRELSPSAKVFYQFVKKFFSRLQQYQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=288, Percent_Identity=29.5138888888889, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790399, Length=297, Percent_Identity=27.2727272727273, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=29.6928327645051, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787530, Length=256, Percent_Identity=28.515625, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367136, Length=268, Percent_Identity=26.4925373134328, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI145693105, Length=296, Percent_Identity=27.027027027027, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=25.2559726962457, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788297, Length=298, Percent_Identity=27.1812080536913, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=28.135593220339, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=290, Percent_Identity=23.1034482758621, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787806, Length=245, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081904, Length=214, Percent_Identity=30.8411214953271, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=27.5720164609054, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788481, Length=298, Percent_Identity=24.8322147651007, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787601, Length=248, Percent_Identity=25, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082132, Length=301, Percent_Identity=22.5913621262458, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786401, Length=142, Percent_Identity=31.6901408450704, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=246, Percent_Identity=23.5772357723577, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789204, Length=294, Percent_Identity=22.108843537415, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=153, Percent_Identity=28.7581699346405, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789506, Length=193, Percent_Identity=23.8341968911917, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788626, Length=243, Percent_Identity=25.5144032921811, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33804; Mature: 33804

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLHYFMEVAEREHVSEAAMHLHVAQSAISRQIANLEEELGVDLFEREGRNVKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCC
GRQFLDHIKTAMKAIDFAKEQIDEYLDPNRGTVKIGFPTSLAGQFLPTVISAFKEEHPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCE
AFLLRQGSYKFLIEAVKNRDIDLAFLGPVPSNIAEIKGDILFSESLLALVPVNHPLSGQK
EEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCEECCCEEEEEECCCCCCCCC
SLHLGDLRNDQYVLFPDGYILRKMAVDACKQVGYTPKISSEGEDLDAIKGLVSADMGVTL
CEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LPESAFNETAPRFTKKIPIDYPQVKRTVGIITPKNRELSPSAKVFYQFVKKFFSRLQQYQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELRQLHYFMEVAEREHVSEAAMHLHVAQSAISRQIANLEEELGVDLFEREGRNVKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCC
GRQFLDHIKTAMKAIDFAKEQIDEYLDPNRGTVKIGFPTSLAGQFLPTVISAFKEEHPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCE
AFLLRQGSYKFLIEAVKNRDIDLAFLGPVPSNIAEIKGDILFSESLLALVPVNHPLSGQK
EEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCEECCCEEEEEECCCCCCCCC
SLHLGDLRNDQYVLFPDGYILRKMAVDACKQVGYTPKISSEGEDLDAIKGLVSADMGVTL
CEEECCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LPESAFNETAPRFTKKIPIDYPQVKRTVGIITPKNRELSPSAKVFYQFVKKFFSRLQQYQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]