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The map label for this gene is yngH [H]

Identifier: 52785894

GI number: 52785894

Start: 2091079

End: 2092419

Strand: Reverse

Name: yngH [H]

Synonym: BLi02143

Alternate gene names: 52785894

Gene position: 2092419-2091079 (Counterclockwise)

Preceding gene: 52785895

Following gene: 52785893

Centisome position: 49.55

GC content: 49.74

Gene sequence:

>1341_bases
TTGTTTAAGAAAGTACTGATTGCCAACCGGGGAGAAATCGCCCTCCGGATCATCCGAACTTGTCAACGGCTCGGTATTCA
GACGGCTGCTGTCTACTCTGAAGCGGATGCGGAGTCCCTGCATGTCAAAGCTGCGGATGAAGCCTGGCTGATCGGCAAAC
CGCGGGTCAGTGAAAGCTATTTAAATATTGAAAAAATCATCGAAACCGCTAAAAAAGCGGGGGTCTGTGCCATTCATCCG
GGATACGGCCTGCTTTCCGAGAACAGCCGTTTTGCCGAAAGGTGCCTCAAGGAGAATATTACGTTTATCGGTCCGCCGCC
TGACGTTATCGCCAAAATGGGAAGCAAAATTGAAGCAAGACAAGCGATGGAACAAGCCGGGGTTCCCGTCGTTCCCGGCG
TGACAAAAAGCTTGTCCGGTCTGAATGAAGCCCGGGCTCTTGCCGAATCCATCGGCTATCCCGTGATGCTCAAGGCTTCT
TTTGGGGGCGGCGGCATCGGAATGCAGCTGATCCGCAATGAAAGCGAATTAGAAAAAGCATATGAAGGCAACCAAAAACG
AGCCGCCGATTTTTTCGGAGACGGGGCTATGTACATCGAGAAATATATCGAACAGGCAAGACATATCGAGATTCAGATTT
TAACAGACAAATACGAAAATGCCGTCTATCTTTGGGAGCGGGACTGTTCGATTCAGAGACGCCAGCAAAAAATCATCGAA
GAAGCACCTGCTCCGTTATTCGATGAAACCATGCGCACAAAGCTCGGTGAAGCGGCCGTGAAAGCTGCGCTGTCGATCGG
CTATGTCAACGCCGGGACAATCGAGTTTTTAGTAGACAAGGAGAATCATTTTTATTTTCTTGAGATGAATACCCGCCTGC
AAGTCGAACACCCGGTGACAGAGGAAATTACAGGGCTTGACCTTGTCGAAGAACAGCTCAATATCGCAGCGGGAAAACCG
CTTTCCCATAAGCAGAAAGACATTCGGCGGGACGGACATGCGATCGAAGTCAGAATCTGTGCCGAAGATCCGAAAACATT
TTTCCCTTCGCCGGGGCGGATTACCGACCTTAAGCTGCCTGAGCAACCGAATGTCCGTCATGAATGCGCAGCAGCCCCGG
GTATGACTATCACCCCGTATTACGACCCGATGATTGCCAAGATGATCGTCAAAGGAAGCAGCAGAGAAGAAGCCATCTGC
ACATTGGCCGAAGCGCTTTCACAATATCAAGTGAAAGGCATTAAAACGAACATTCCGCTCCTTGAAGACATTGTAAGTTC
TGACGAATTCCGAAAAGGCGGGGTCCAAACCGATTTTATCAGTCGCTATCAGTCAAAATGA

Upstream 100 bases:

>100_bases
AGGGAAAGTGCAAAAATTCAAGTTAAGGGAGCAGGCGCTTGAGCATTTTCAATTGTAATTTTCTCTTTCAAGCGCGACTA
ACATAAAAGGAGGGACCTTT

Downstream 100 bases:

>100_bases
AATCAAGGAGGCGTACTATGAATACTGTTGTCACCAATATGGCAGGAAACGTGTGGAAAATATTAGTGAAAGCGGGGGAC
AAAATCGAAAAGGGGCAGGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFKKVLIANRGEIALRIIRTCQRLGIQTAAVYSEADAESLHVKAADEAWLIGKPRVSESYLNIEKIIETAKKAGVCAIHP
GYGLLSENSRFAERCLKENITFIGPPPDVIAKMGSKIEARQAMEQAGVPVVPGVTKSLSGLNEARALAESIGYPVMLKAS
FGGGGIGMQLIRNESELEKAYEGNQKRAADFFGDGAMYIEKYIEQARHIEIQILTDKYENAVYLWERDCSIQRRQQKIIE
EAPAPLFDETMRTKLGEAAVKAALSIGYVNAGTIEFLVDKENHFYFLEMNTRLQVEHPVTEEITGLDLVEEQLNIAAGKP
LSHKQKDIRRDGHAIEVRICAEDPKTFFPSPGRITDLKLPEQPNVRHECAAAPGMTITPYYDPMIAKMIVKGSSREEAIC
TLAEALSQYQVKGIKTNIPLLEDIVSSDEFRKGGVQTDFISRYQSK

Sequences:

>Translated_446_residues
MFKKVLIANRGEIALRIIRTCQRLGIQTAAVYSEADAESLHVKAADEAWLIGKPRVSESYLNIEKIIETAKKAGVCAIHP
GYGLLSENSRFAERCLKENITFIGPPPDVIAKMGSKIEARQAMEQAGVPVVPGVTKSLSGLNEARALAESIGYPVMLKAS
FGGGGIGMQLIRNESELEKAYEGNQKRAADFFGDGAMYIEKYIEQARHIEIQILTDKYENAVYLWERDCSIQRRQQKIIE
EAPAPLFDETMRTKLGEAAVKAALSIGYVNAGTIEFLVDKENHFYFLEMNTRLQVEHPVTEEITGLDLVEEQLNIAAGKP
LSHKQKDIRRDGHAIEVRICAEDPKTFFPSPGRITDLKLPEQPNVRHECAAAPGMTITPYYDPMIAKMIVKGSSREEAIC
TLAEALSQYQVKGIKTNIPLLEDIVSSDEFRKGGVQTDFISRYQSK
>Mature_446_residues
MFKKVLIANRGEIALRIIRTCQRLGIQTAAVYSEADAESLHVKAADEAWLIGKPRVSESYLNIEKIIETAKKAGVCAIHP
GYGLLSENSRFAERCLKENITFIGPPPDVIAKMGSKIEARQAMEQAGVPVVPGVTKSLSGLNEARALAESIGYPVMLKAS
FGGGGIGMQLIRNESELEKAYEGNQKRAADFFGDGAMYIEKYIEQARHIEIQILTDKYENAVYLWERDCSIQRRQQKIIE
EAPAPLFDETMRTKLGEAAVKAALSIGYVNAGTIEFLVDKENHFYFLEMNTRLQVEHPVTEEITGLDLVEEQLNIAAGKP
LSHKQKDIRRDGHAIEVRICAEDPKTFFPSPGRITDLKLPEQPNVRHECAAAPGMTITPYYDPMIAKMIVKGSSREEAIC
TLAEALSQYQVKGIKTNIPLLEDIVSSDEFRKGGVQTDFISRYQSK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=51.0112359550562, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=50.6756756756757, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=50.6756756756757, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=50.6756756756757, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=46.6216216216216, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=46.6216216216216, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=46.6216216216216, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=31.547619047619, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=31.547619047619, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=31.547619047619, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=31.547619047619, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=31.547619047619, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=30.8151093439364, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI18105007, Length=221, Percent_Identity=24.4343891402715, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=50.1128668171558, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=49.6629213483146, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.1538461538462, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=45.8797327394209, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=30.2371541501976, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=30.2371541501976, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=31.237322515213, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=45.2914798206278, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=43.2735426008969, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=43.75, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=32.0879120879121, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=29.4117647058824, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322331, Length=313, Percent_Identity=23.3226837060703, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=48.7528344671202, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=47.9012345679012, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=30.3822937625755, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=30.784708249497, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=30.784708249497, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=30.784708249497, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49565; Mature: 49565

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKVLIANRGEIALRIIRTCQRLGIQTAAVYSEADAESLHVKAADEAWLIGKPRVSESY
CCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCEEECCCCCCCHHH
LNIEKIIETAKKAGVCAIHPGYGLLSENSRFAERCLKENITFIGPPPDVIAKMGSKIEAR
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHCCCHHHHH
QAMEQAGVPVVPGVTKSLSGLNEARALAESIGYPVMLKASFGGGGIGMQLIRNESELEKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCHHHHHHH
YEGNQKRAADFFGDGAMYIEKYIEQARHIEIQILTDKYENAVYLWERDCSIQRRQQKIIE
HCCCCHHHHHHCCCCHHHHHHHHHHHHCEEEEEEEECCCCEEEEEECCCCHHHHHHHHHH
EAPAPLFDETMRTKLGEAAVKAALSIGYVNAGTIEFLVDKENHFYFLEMNTRLQVEHPVT
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEEQLNIAAGKPLSHKQKDIRRDGHAIEVRICAEDPKTFFPSPGRITDLKLP
HHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEECCCC
EQPNVRHECAAAPGMTITPYYDPMIAKMIVKGSSREEAICTLAEALSQYQVKGIKTNIPL
CCCCCCHHHHCCCCCEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
LEDIVSSDEFRKGGVQTDFISRYQSK
HHHHHCCCHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure
MFKKVLIANRGEIALRIIRTCQRLGIQTAAVYSEADAESLHVKAADEAWLIGKPRVSESY
CCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCEEECCCCCCCHHH
LNIEKIIETAKKAGVCAIHPGYGLLSENSRFAERCLKENITFIGPPPDVIAKMGSKIEAR
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHCCCHHHHH
QAMEQAGVPVVPGVTKSLSGLNEARALAESIGYPVMLKASFGGGGIGMQLIRNESELEKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCHHHHHHH
YEGNQKRAADFFGDGAMYIEKYIEQARHIEIQILTDKYENAVYLWERDCSIQRRQQKIIE
HCCCCHHHHHHCCCCHHHHHHHHHHHHCEEEEEEEECCCCEEEEEECCCCHHHHHHHHHH
EAPAPLFDETMRTKLGEAAVKAALSIGYVNAGTIEFLVDKENHFYFLEMNTRLQVEHPVT
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEEQLNIAAGKPLSHKQKDIRRDGHAIEVRICAEDPKTFFPSPGRITDLKLP
HHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEECCCC
EQPNVRHECAAAPGMTITPYYDPMIAKMIVKGSSREEAICTLAEALSQYQVKGIKTNIPL
CCCCCCHHHHCCCCCEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
LEDIVSSDEFRKGGVQTDFISRYQSK
HHHHHCCCHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]