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The map label for this gene is adhA [H]

Identifier: 52785850

GI number: 52785850

Start: 2040141

End: 2041199

Strand: Reverse

Name: adhA [H]

Synonym: BLi02097

Alternate gene names: 52785850

Gene position: 2041199-2040141 (Counterclockwise)

Preceding gene: 52785852

Following gene: 52785849

Centisome position: 48.34

GC content: 50.42

Gene sequence:

>1059_bases
ATGTGTAATCTGCATAAAACCATCTCAACCCGTGTACTGAGTGCTCCGAGAGCCAAGGCGAAATTTGAACAGACCACAAT
TGAAAGAAGGGAATTACAACCGAATGACGTTTTAATCGATATTAAGTACAGCGGCATTTGCCATTCGGATATCCATAGCG
CGTACGATGAATGGGGAGGCGGAATCTTCCCAATGGTTCCGGGACATGAAATCGCCGGCATCGTCAAAGCAGTTGGGACA
AGTGTTAAAAAATTTGCTGTCGGCGACCGCGTGGGGGTCGGCTGCTTCGTTGACTCTTGCGGCGAATGTGAATACTGCCA
GAGCGGAGAGGAGCAATTTTGTACGAAAGGCGTGATCCAAACGTATAACTGTTTAGACTACGATGGAAATCCGACATATG
GCGGTTACAGCCAATACATCGTGGTTAAAGAAGATTTTGTTGTCCGCATTCCGGACAGCCTGAACTTGGATGTTGCAAGC
CCGCTCTTGTGCGCAGGCATCACCACGTACTCTCCTTTGAAGCATTGGAACGCAGGCCCCGGCAAGAAAGTTGCCGTTGT
GGGAATGGGGGGACTCGGCCACGTCGCCATCCAATTTGCGCATGCCATGGGGGCAGAAGTAACGGTCTTAAGCCGCTCTT
TGAATAAACAGGAAGAAGCCTTGCGTTTTGGCGCAGATCATTACTTTGCAACTGGCGACCCTGCAGTATTCACTGAGCTG
GCCGGACGCTTTGATCTTATTTTAAACACGGTGTCCGCCAATCTGGACGTTGATGCATACTTATCGCTTCTTCGCGCCGA
TGGAACACTTGTTAACGTCGGCGCGCCGGCAGAACGGGATCAGTACAGTGTGTTTTCCTTAATCATGGGCCGCCGCAGCA
TTGCAGGTTCGCTTGTCGGCGGCATTCGGGAGACACAAGAGATGCTTGATTTCGCTGCTGAACACGGCTTGGCTCCGCAA
ATTGAGGTCATCGGAGCTGACCAAGTAGATGAAGCATATGAGCGCGTCCTCAAAAGCGATGTGCGTTATCGATTCGTGAT
TGATGTCTCTACTTTGTAA

Upstream 100 bases:

>100_bases
GAAAAACCTCTTGCCTTAAAGCGAACTTTAAGGTTTAACCTTAACTTGCACCTCTTCTCTATGAATTGGCGTAATATAAC
GTAAGAAAGGATCGATATGG

Downstream 100 bases:

>100_bases
ATCATATATAATAACAGATAGGCCAGTCATTTTATTTGACTGGCCGCTTTTCTTAGCTTTTGCCCCGCATGACCCGGCAA
TTTCAGCCGAGCGAATGAAG

Product: AdhA

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MCNLHKTISTRVLSAPRAKAKFEQTTIERRELQPNDVLIDIKYSGICHSDIHSAYDEWGGGIFPMVPGHEIAGIVKAVGT
SVKKFAVGDRVGVGCFVDSCGECEYCQSGEEQFCTKGVIQTYNCLDYDGNPTYGGYSQYIVVKEDFVVRIPDSLNLDVAS
PLLCAGITTYSPLKHWNAGPGKKVAVVGMGGLGHVAIQFAHAMGAEVTVLSRSLNKQEEALRFGADHYFATGDPAVFTEL
AGRFDLILNTVSANLDVDAYLSLLRADGTLVNVGAPAERDQYSVFSLIMGRRSIAGSLVGGIRETQEMLDFAAEHGLAPQ
IEVIGADQVDEAYERVLKSDVRYRFVIDVSTL

Sequences:

>Translated_352_residues
MCNLHKTISTRVLSAPRAKAKFEQTTIERRELQPNDVLIDIKYSGICHSDIHSAYDEWGGGIFPMVPGHEIAGIVKAVGT
SVKKFAVGDRVGVGCFVDSCGECEYCQSGEEQFCTKGVIQTYNCLDYDGNPTYGGYSQYIVVKEDFVVRIPDSLNLDVAS
PLLCAGITTYSPLKHWNAGPGKKVAVVGMGGLGHVAIQFAHAMGAEVTVLSRSLNKQEEALRFGADHYFATGDPAVFTEL
AGRFDLILNTVSANLDVDAYLSLLRADGTLVNVGAPAERDQYSVFSLIMGRRSIAGSLVGGIRETQEMLDFAAEHGLAPQ
IEVIGADQVDEAYERVLKSDVRYRFVIDVSTL
>Mature_352_residues
MCNLHKTISTRVLSAPRAKAKFEQTTIERRELQPNDVLIDIKYSGICHSDIHSAYDEWGGGIFPMVPGHEIAGIVKAVGT
SVKKFAVGDRVGVGCFVDSCGECEYCQSGEEQFCTKGVIQTYNCLDYDGNPTYGGYSQYIVVKEDFVVRIPDSLNLDVAS
PLLCAGITTYSPLKHWNAGPGKKVAVVGMGGLGHVAIQFAHAMGAEVTVLSRSLNKQEEALRFGADHYFATGDPAVFTEL
AGRFDLILNTVSANLDVDAYLSLLRADGTLVNVGAPAERDQYSVFSLIMGRRSIAGSLVGGIRETQEMLDFAAEHGLAPQ
IEVIGADQVDEAYERVLKSDVRYRFVIDVSTL

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=324, Percent_Identity=28.7037037037037, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI34577061, Length=346, Percent_Identity=27.4566473988439, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4501929, Length=321, Percent_Identity=27.7258566978193, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71565152, Length=324, Percent_Identity=26.5432098765432, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=26.2390670553936, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.2390670553936, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=27.0777479892761, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=27.0777479892761, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI71565154, Length=362, Percent_Identity=24.8618784530387, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=261, Percent_Identity=27.9693486590038, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=53.5816618911175, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI87082401, Length=336, Percent_Identity=36.9047619047619, Blast_Score=208, Evalue=4e-55,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=30.6501547987616, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1788075, Length=302, Percent_Identity=27.8145695364238, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788073, Length=197, Percent_Identity=32.48730964467, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790045, Length=205, Percent_Identity=31.219512195122, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786552, Length=234, Percent_Identity=31.1965811965812, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082125, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=249, Percent_Identity=30.1204819277108, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=29.2592592592593, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=27.3615635179153, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI226510992, Length=258, Percent_Identity=28.2945736434109, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786825, Length=253, Percent_Identity=28.8537549407115, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=327, Percent_Identity=32.4159021406728, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=31.8181818181818, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562582, Length=328, Percent_Identity=31.4024390243902, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=235, Percent_Identity=31.9148936170213, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=281, Percent_Identity=25.9786476868327, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=237, Percent_Identity=31.6455696202532, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=214, Percent_Identity=30.8411214953271, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=200, Percent_Identity=32.5, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=39.2749244712991, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319949, Length=319, Percent_Identity=35.7366771159875, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=33.3333333333333, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=33.6257309941521, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=33.1360946745562, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323729, Length=340, Percent_Identity=31.1764705882353, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320033, Length=304, Percent_Identity=29.9342105263158, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=268, Percent_Identity=29.1044776119403, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=327, Percent_Identity=25.6880733944954, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=24.203821656051, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=274, Percent_Identity=29.9270072992701, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=274, Percent_Identity=29.9270072992701, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=332, Percent_Identity=27.1084337349398, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=215, Percent_Identity=30.2325581395349, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137530, Length=215, Percent_Identity=30.2325581395349, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 38187; Mature: 38187

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNLHKTISTRVLSAPRAKAKFEQTTIERRELQPNDVLIDIKYSGICHSDIHSAYDEWGG
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
GIFPMVPGHEIAGIVKAVGTSVKKFAVGDRVGVGCFVDSCGECEYCQSGEEQFCTKGVIQ
CCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHH
TYNCLDYDGNPTYGGYSQYIVVKEDFVVRIPDSLNLDVASPLLCAGITTYSPLKHWNAGP
HCCEECCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCHHHHHCCCCCCCHHHCCCCC
GKKVAVVGMGGLGHVAIQFAHAMGAEVTVLSRSLNKQEEALRFGADHYFATGDPAVFTEL
CCEEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHCHHHHHHHHCCCCEEECCCHHHHHHH
AGRFDLILNTVSANLDVDAYLSLLRADGTLVNVGAPAERDQYSVFSLIMGRRSIAGSLVG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GIRETQEMLDFAAEHGLAPQIEVIGADQVDEAYERVLKSDVRYRFVIDVSTL
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEEEECC
>Mature Secondary Structure
MCNLHKTISTRVLSAPRAKAKFEQTTIERRELQPNDVLIDIKYSGICHSDIHSAYDEWGG
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
GIFPMVPGHEIAGIVKAVGTSVKKFAVGDRVGVGCFVDSCGECEYCQSGEEQFCTKGVIQ
CCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHH
TYNCLDYDGNPTYGGYSQYIVVKEDFVVRIPDSLNLDVASPLLCAGITTYSPLKHWNAGP
HCCEECCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCHHHHHCCCCCCCHHHCCCCC
GKKVAVVGMGGLGHVAIQFAHAMGAEVTVLSRSLNKQEEALRFGADHYFATGDPAVFTEL
CCEEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHCHHHHHHHHCCCCEEECCCHHHHHHH
AGRFDLILNTVSANLDVDAYLSLLRADGTLVNVGAPAERDQYSVFSLIMGRRSIAGSLVG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GIRETQEMLDFAAEHGLAPQIEVIGADQVDEAYERVLKSDVRYRFVIDVSTL
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]