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The map label for this gene is ytcA [H]

Identifier: 52784609

GI number: 52784609

Start: 828615

End: 829910

Strand: Direct

Name: ytcA [H]

Synonym: BLi00810

Alternate gene names: 52784609

Gene position: 828615-829910 (Clockwise)

Preceding gene: 52784608

Following gene: 52784610

Centisome position: 19.62

GC content: 49.07

Gene sequence:

>1296_bases
ATGAGCAAACAGGAAATTCATAACGAAACGATAGCGGTCATCGGCTTGGGGTTTGTCGGTCTGCCCTTGGCCATGTTGTT
GATATCAAAAGGAATGCGGGTTATCGGTGTTGATTTGGACAAAAAGAAAGTCGAGGCATTGCGGAAAGGAACCAGCTATA
TTTCGGATATAAACGATCAAGCGGTGCAGGACGGAATAGGCACCGGTTTCTTTCGTCCTGTTTCGGACTACAGTTTAATC
GGTGAAGCGGATGCCGTCATCATCTGCGTGCCGACGCCTTTGAATGATGATGCGGGTCCTGATTTGAATTATGTGAAAAG
AGCGGCGCAATTGATTGGAGCGCACTTGAAAAAAGGGCAGCTCGTCGTGTTGGAAAGCTCGACATATCCGGGTACGACAA
GAGACATCGTCAAACCGATCCTGGAAAAAAGCGGCCTTGTATGCGGGAAGGATTTTTACTTGGCTTATTCTCCAGAACGC
GTTGATCCGGGCAATCAGTTCCCGATTGAGGTCGTGCCGAAGGTAGTGGGAGGAGCGACGGATGCATGCCTTGAAAAGGT
GCATCAATTATACAGCGGCATTTATGAAGAGGTTGTGCCTGTTACATCGCCAGAAACAGCGGAGCTGACAAAGCTGCTCG
AAAATACGTACCGGTTTATTAATATTTCATTCATTAATGAATTCGCGATGATATGCGACAGGCTCGGGGTGAATGTGTGG
GAAGTCATCGAGGCGGCAAGCACGAAGCCGTATGGGTTTGCGGCTTTTTATCCAGGCCCCGGCATCGGCGGCCATTGCAT
CCCCGTCGACCCGCTGTATTTGCAGTTTGTCATGAAACAAAGCGGATTATCGAGCGACTTTATCGAGCTGTCGGAAGCGA
CAAATGATAGAATCGTCCGCTATATTTCAGAGCGCTCCTTGCAGCTGGCAGGGAAAGACAAGGCGACAGACGCCCGCATC
TTAATCTACGGCGTCACCTATAAACGAAATATCGCGGATGTCCGCGAATCAAAATCGCTTGATATTATAGAGAAGCTGAT
CGGCATGGGAGCAGATGTTTCCTACCATGATCCGCACGTTCCGGACCTCGACCTCAGCGGCAAAAAGCTAGCAAGCGTGC
CGATAGATTCAAAGATGCTGAAAGAGTATGACTGTGTTGTCATTTTAACTGATCATGACGCACTCCCGAAAGAGCTGTTA
TTAAACCATGCAAACGTGATATTTGATACGAGAGGAGTGCTGAGGGAAGCAGCCGGAAAAGCAAAAGTCATCCAGCTCGG
AAACGGGCGCTCCTGA

Upstream 100 bases:

>100_bases
ATGAAAAATAAATAGGTTTTGTTTTGGTAGATCGTCCCTTTCAAAAAAAGATTTGAAACATAGTTTATTAAAGGAATGTA
CAGAAGGGGCGAGTTGATAA

Downstream 100 bases:

>100_bases
ATCAATTTTTCTGCAGCGACTCACGCCCAGATCCGTTCGGAATACAATAAGTTAAAACAAGAACGAAAAGGGTGAGGGCC
GTGTGGATCGGAATTCTGTT

Product: YtcA

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSKQEIHNETIAVIGLGFVGLPLAMLLISKGMRVIGVDLDKKKVEALRKGTSYISDINDQAVQDGIGTGFFRPVSDYSLI
GEADAVIICVPTPLNDDAGPDLNYVKRAAQLIGAHLKKGQLVVLESSTYPGTTRDIVKPILEKSGLVCGKDFYLAYSPER
VDPGNQFPIEVVPKVVGGATDACLEKVHQLYSGIYEEVVPVTSPETAELTKLLENTYRFINISFINEFAMICDRLGVNVW
EVIEAASTKPYGFAAFYPGPGIGGHCIPVDPLYLQFVMKQSGLSSDFIELSEATNDRIVRYISERSLQLAGKDKATDARI
LIYGVTYKRNIADVRESKSLDIIEKLIGMGADVSYHDPHVPDLDLSGKKLASVPIDSKMLKEYDCVVILTDHDALPKELL
LNHANVIFDTRGVLREAAGKAKVIQLGNGRS

Sequences:

>Translated_431_residues
MSKQEIHNETIAVIGLGFVGLPLAMLLISKGMRVIGVDLDKKKVEALRKGTSYISDINDQAVQDGIGTGFFRPVSDYSLI
GEADAVIICVPTPLNDDAGPDLNYVKRAAQLIGAHLKKGQLVVLESSTYPGTTRDIVKPILEKSGLVCGKDFYLAYSPER
VDPGNQFPIEVVPKVVGGATDACLEKVHQLYSGIYEEVVPVTSPETAELTKLLENTYRFINISFINEFAMICDRLGVNVW
EVIEAASTKPYGFAAFYPGPGIGGHCIPVDPLYLQFVMKQSGLSSDFIELSEATNDRIVRYISERSLQLAGKDKATDARI
LIYGVTYKRNIADVRESKSLDIIEKLIGMGADVSYHDPHVPDLDLSGKKLASVPIDSKMLKEYDCVVILTDHDALPKELL
LNHANVIFDTRGVLREAAGKAKVIQLGNGRS
>Mature_430_residues
SKQEIHNETIAVIGLGFVGLPLAMLLISKGMRVIGVDLDKKKVEALRKGTSYISDINDQAVQDGIGTGFFRPVSDYSLIG
EADAVIICVPTPLNDDAGPDLNYVKRAAQLIGAHLKKGQLVVLESSTYPGTTRDIVKPILEKSGLVCGKDFYLAYSPERV
DPGNQFPIEVVPKVVGGATDACLEKVHQLYSGIYEEVVPVTSPETAELTKLLENTYRFINISFINEFAMICDRLGVNVWE
VIEAASTKPYGFAAFYPGPGIGGHCIPVDPLYLQFVMKQSGLSSDFIELSEATNDRIVRYISERSLQLAGKDKATDARIL
IYGVTYKRNIADVRESKSLDIIEKLIGMGADVSYHDPHVPDLDLSGKKLASVPIDSKMLKEYDCVVILTDHDALPKELLL
NHANVIFDTRGVLREAAGKAKVIQLGNGRS

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=369, Percent_Identity=26.2872628726287, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI296040438, Length=271, Percent_Identity=26.1992619926199, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI296040443, Length=195, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI48994968, Length=427, Percent_Identity=34.192037470726, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788340, Length=397, Percent_Identity=24.4332493702771, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=447, Percent_Identity=25.7270693512304, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136908, Length=372, Percent_Identity=24.7311827956989, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47072; Mature: 46941

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQEIHNETIAVIGLGFVGLPLAMLLISKGMRVIGVDLDKKKVEALRKGTSYISDINDQ
CCHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHH
AVQDGIGTGFFRPVSDYSLIGEADAVIICVPTPLNDDAGPDLNYVKRAAQLIGAHLKKGQ
HHHHCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
LVVLESSTYPGTTRDIVKPILEKSGLVCGKDFYLAYSPERVDPGNQFPIEVVPKVVGGAT
EEEEECCCCCCCHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCHHHHHHHHCCCH
DACLEKVHQLYSGIYEEVVPVTSPETAELTKLLENTYRFINISFINEFAMICDRLGVNVW
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHH
EVIEAASTKPYGFAAFYPGPGIGGHCIPVDPLYLQFVMKQSGLSSDFIELSEATNDRIVR
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH
YISERSLQLAGKDKATDARILIYGVTYKRNIADVRESKSLDIIEKLIGMGADVSYHDPHV
HHHHCCCEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
PDLDLSGKKLASVPIDSKMLKEYDCVVILTDHDALPKELLLNHANVIFDTRGVLREAAGK
CCCCCCCCEEECCCCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCCEEECHHHHHHHCCC
AKVIQLGNGRS
EEEEECCCCCC
>Mature Secondary Structure 
SKQEIHNETIAVIGLGFVGLPLAMLLISKGMRVIGVDLDKKKVEALRKGTSYISDINDQ
CHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHH
AVQDGIGTGFFRPVSDYSLIGEADAVIICVPTPLNDDAGPDLNYVKRAAQLIGAHLKKGQ
HHHHCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
LVVLESSTYPGTTRDIVKPILEKSGLVCGKDFYLAYSPERVDPGNQFPIEVVPKVVGGAT
EEEEECCCCCCCHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCHHHHHHHHCCCH
DACLEKVHQLYSGIYEEVVPVTSPETAELTKLLENTYRFINISFINEFAMICDRLGVNVW
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHH
EVIEAASTKPYGFAAFYPGPGIGGHCIPVDPLYLQFVMKQSGLSSDFIELSEATNDRIVR
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH
YISERSLQLAGKDKATDARILIYGVTYKRNIADVRESKSLDIIEKLIGMGADVSYHDPHV
HHHHCCCEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
PDLDLSGKKLASVPIDSKMLKEYDCVVILTDHDALPKELLLNHANVIFDTRGVLREAAGK
CCCCCCCCEEECCCCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCCEEECHHHHHHHCCC
AKVIQLGNGRS
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA