Click here to switch to the map view.

The map label for this gene is bioI [H]

Identifier: 52784570

GI number: 52784570

Start: 782533

End: 783729

Strand: Direct

Name: bioI [H]

Synonym: BLi00771

Alternate gene names: 52784570

Gene position: 782533-783729 (Clockwise)

Preceding gene: 52784569

Following gene: 52784572

Centisome position: 18.53

GC content: 49.79

Gene sequence:

>1197_bases
ATGACGACAGAACTGCACGAGGCAGGGCCGAGCCTGAAATCGGATTCGGATTTTTGGAGAGATCCATATCTGTTTTACGA
TCAGCTGCGGTCCATTCATCCTGTATATAAAGGAACCGTTTTAAAGCATCCGGGCTGGTATGTCACCGGATATGAAGAAG
CGGCAGCGATTTTGAAGGAACCGGCATTTATAAACCGCGTTCCTCTCCCAGAAGCTTCTACTAAATATGAACAACTTCAG
CGATTGCAGCGAAATATGATGCTGTTTCAAAATGAGTCCGGCCATAAGCGGATGCGGACGATTGCCGGCAAAGAATTCAT
GCCGCAGAAGACGGCAACTTTCCGCCCTGCTATAGAAGAAACCGTCCATGAATTGCTCGATCAGCTTGAAAACAAGAAGA
CGGCGGACATGGTATCGGAATTCGCCTTTCCTTTGGCAAGCCTTATCATTGCCGGCATGCTCGGCGTCCCGGAAGAGGAA
TGGTACCAATTCAGGCAATGGACGGCGGATCTCATTCAAACGATCGATTTGACCCGTACACGAAAGGTAATGGCAAAAGG
CGGTGATACCGTTGCCAAGCTGACGGCTTATTTTAAAAATTTAATTGAAAAGCGAAAAGCGCATCCTTCTGAAGACCTGA
TCAGCACATTCGCCGGTCATGAGCAGCTTGCTGATGAAGAAGTGCTTGCGACGTGCATCCTGCTTGTGATTGCCGGACAT
GAGACGACAGTCAACCTTTTGACGAACGGGTTGTTTTTGCTCATGACACATCCTGACCAGCTCAGTGAGCTGAAAGAAAA
TCCGCTGCTGATTGAGTCGGCCGTCGAAGAATGTCTTCGCTATGAAAGCCCGACACAGCTGACAGCGCGCACCGCGTCGG
AGGACTGCGAAATCAACGGGAAAATCATCAAAAAAGGAGAGCACTTATATATCCTTTTAGGCGCCGCCAACCGCGATCCA
AAGATATTTCAAAACCCGCATCTATTTGACATCACAAGAAAGCCGAATCCGCACCTTGCCTTTGGAGCCGGTGCGCACGT
ATGTTTAGGCTCGGCATTGGCGCGGCTCGAAGCGCAAATTGCCATTCCCGCACTGTTGGCGCGGCTGCCTAACTTGAAGC
TTGCTTCAACAGACGTTCCATTTCGCAGGCTAATCGGCTTTAGATCGCTGGCCGAGCTGCCTGTCATCCTCAATTAA

Upstream 100 bases:

>100_bases
AAACAGAGGACCATAAGATGCTTCATGATTTAGGGTTCGAAGTCGAATCGGTCGAAGAAATGAAAGCCAGTTTACAGCGG
TAGCACGGGGGAGATATAAC

Downstream 100 bases:

>100_bases
AGACGACGAAAAAAGGGGCTGGCTTACAGGTGCCGGCCCTTTTTAATCTTTCTTTTCATTTTGGGTAATATAGGTTTGCA
GAAGCGCCTTTAATTCTTTG

Product: BioI

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTTELHEAGPSLKSDSDFWRDPYLFYDQLRSIHPVYKGTVLKHPGWYVTGYEEAAAILKEPAFINRVPLPEASTKYEQLQ
RLQRNMMLFQNESGHKRMRTIAGKEFMPQKTATFRPAIEETVHELLDQLENKKTADMVSEFAFPLASLIIAGMLGVPEEE
WYQFRQWTADLIQTIDLTRTRKVMAKGGDTVAKLTAYFKNLIEKRKAHPSEDLISTFAGHEQLADEEVLATCILLVIAGH
ETTVNLLTNGLFLLMTHPDQLSELKENPLLIESAVEECLRYESPTQLTARTASEDCEINGKIIKKGEHLYILLGAANRDP
KIFQNPHLFDITRKPNPHLAFGAGAHVCLGSALARLEAQIAIPALLARLPNLKLASTDVPFRRLIGFRSLAELPVILN

Sequences:

>Translated_398_residues
MTTELHEAGPSLKSDSDFWRDPYLFYDQLRSIHPVYKGTVLKHPGWYVTGYEEAAAILKEPAFINRVPLPEASTKYEQLQ
RLQRNMMLFQNESGHKRMRTIAGKEFMPQKTATFRPAIEETVHELLDQLENKKTADMVSEFAFPLASLIIAGMLGVPEEE
WYQFRQWTADLIQTIDLTRTRKVMAKGGDTVAKLTAYFKNLIEKRKAHPSEDLISTFAGHEQLADEEVLATCILLVIAGH
ETTVNLLTNGLFLLMTHPDQLSELKENPLLIESAVEECLRYESPTQLTARTASEDCEINGKIIKKGEHLYILLGAANRDP
KIFQNPHLFDITRKPNPHLAFGAGAHVCLGSALARLEAQIAIPALLARLPNLKLASTDVPFRRLIGFRSLAELPVILN
>Mature_397_residues
TTELHEAGPSLKSDSDFWRDPYLFYDQLRSIHPVYKGTVLKHPGWYVTGYEEAAAILKEPAFINRVPLPEASTKYEQLQR
LQRNMMLFQNESGHKRMRTIAGKEFMPQKTATFRPAIEETVHELLDQLENKKTADMVSEFAFPLASLIIAGMLGVPEEEW
YQFRQWTADLIQTIDLTRTRKVMAKGGDTVAKLTAYFKNLIEKRKAHPSEDLISTFAGHEQLADEEVLATCILLVIAGHE
TTVNLLTNGLFLLMTHPDQLSELKENPLLIESAVEECLRYESPTQLTARTASEDCEINGKIIKKGEHLYILLGAANRDPK
IFQNPHLFDITRKPNPHLAFGAGAHVCLGSALARLEAQIAIPALLARLPNLKLASTDVPFRRLIGFRSLAELPVILN

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI13435386, Length=206, Percent_Identity=28.1553398058252, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI195972896, Length=188, Percent_Identity=27.1276595744681, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI195972898, Length=188, Percent_Identity=27.1276595744681, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI261278370, Length=188, Percent_Identity=27.1276595744681, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI261278372, Length=188, Percent_Identity=27.1276595744681, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262290932, Length=250, Percent_Identity=24.8, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4503231, Length=190, Percent_Identity=27.8947368421053, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI16933533, Length=213, Percent_Identity=24.8826291079812, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI187960086, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI12383060, Length=218, Percent_Identity=23.8532110091743, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17933518, Length=234, Percent_Identity=24.3589743589744, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24642101, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355669, Length=234, Percent_Identity=24.3589743589744, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 44837; Mature: 44706

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTELHEAGPSLKSDSDFWRDPYLFYDQLRSIHPVYKGTVLKHPGWYVTGYEEAAAILKE
CCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCEEECCCEEEECHHHHHHHHHC
PAFINRVPLPEASTKYEQLQRLQRNMMLFQNESGHKRMRTIAGKEFMPQKTATFRPAIEE
CCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
TVHELLDQLENKKTADMVSEFAFPLASLIIAGMLGVPEEEWYQFRQWTADLIQTIDLTRT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RKVMAKGGDTVAKLTAYFKNLIEKRKAHPSEDLISTFAGHEQLADEEVLATCILLVIAGH
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
ETTVNLLTNGLFLLMTHPDQLSELKENPLLIESAVEECLRYESPTQLTARTASEDCEING
CHHHHHHHCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
KIIKKGEHLYILLGAANRDPKIFQNPHLFDITRKPNPHLAFGAGAHVCLGSALARLEAQI
EEEECCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHH
AIPALLARLPNLKLASTDVPFRRLIGFRSLAELPVILN
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTELHEAGPSLKSDSDFWRDPYLFYDQLRSIHPVYKGTVLKHPGWYVTGYEEAAAILKE
CCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCEEECCCEEEECHHHHHHHHHC
PAFINRVPLPEASTKYEQLQRLQRNMMLFQNESGHKRMRTIAGKEFMPQKTATFRPAIEE
CCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
TVHELLDQLENKKTADMVSEFAFPLASLIIAGMLGVPEEEWYQFRQWTADLIQTIDLTRT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RKVMAKGGDTVAKLTAYFKNLIEKRKAHPSEDLISTFAGHEQLADEEVLATCILLVIAGH
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
ETTVNLLTNGLFLLMTHPDQLSELKENPLLIESAVEECLRYESPTQLTARTASEDCEING
CHHHHHHHCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
KIIKKGEHLYILLGAANRDPKIFQNPHLFDITRKPNPHLAFGAGAHVCLGSALARLEAQI
EEEECCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHH
AIPALLARLPNLKLASTDVPFRRLIGFRSLAELPVILN
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]