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The map label for this gene is nhaC [H]

Identifier: 52784352

GI number: 52784352

Start: 538322

End: 539611

Strand: Reverse

Name: nhaC [H]

Synonym: BLi00532

Alternate gene names: 52784352

Gene position: 539611-538322 (Counterclockwise)

Preceding gene: 52784361

Following gene: 52784350

Centisome position: 12.78

GC content: 51.32

Gene sequence:

>1290_bases
ATGCAAAATCAAAACGGAAAAGCCTCAGGGCTTTTGCCGCTGTTTTTATTTGTTTGTTTATTCGTTGGATCAGGCTTGAT
CACAGGCGACTTTTACAGCCTGCCAATCGTGGCCGCGGCGCTTGCGGCATCGGTTGTCTCACTGGCGATGAACAGGAAGG
AGAAGCTCAGCCAAAAGACGGAGTGGTTTGCGAAGGGCGCCGGGCACCCCGACATAATGATCATGGTGATGATCTTTATT
TTGGCCGGAGCGTTTTCATCAGCCGCAAAGGCGATGGGGGCCGTCGAATCAACCGTTAATCTCGCGCTTTCATTTGTACC
GGGGCAGTTTATGGTTGCCGGTTTATTTATCATCGCTGCGTTTATCTCTGTGTCGATGGGCACGTCAACCGGAACGATTG
CTGCGCTCGCTCCGATCGCAGCGGGGATTAGCGCTGAAATCGGCGTTCCGGCGGCATATTCGGTTGCTGCGGTTGTGGGG
GGCGCGATGTTCGGCGATAACTTATCATTTATTTCCGATACGACCATTGCCGCTGTCCGCACTCAAAAGACGAAAATGTC
GGACAAGTTTAAAACGAATTTCCTGATCGTTCTGCCTGCCGCGGTTGCCACGGTCATTCTGCTGATGGTGTTCTCAGCCG
GAGGGCATCCCGGAGCACAAGCCGGGACTTACAGCTGGGTGAAGGTGCTGCCGTATCTCGGGGTTCTGATATTTGCCCTT
CTCGGATTTAATGTTATGGCCGTTATTTTCGGCGGCATCGTATTAGCCGGGGTAATCGGAATTTCCGACGGAAGCCTGAC
GCTTCATACGTATTTGACGGCGATAACCGAAGGCATCGGCGGGATGTCTGAACTGATCATTTTATCGCTTCTGATTGGCG
GAATGGCGGAAATGATGAAGCGAAACGGCGGGATCGCGTTTCTCCTTCAATTTGTATCGCGGAGAATCCGTTCAAAAAAA
GGAGCTGAAGCGGGCATTGCCGGCCTTGTCAGCGCGGCAAACCTGGCGACGGCCAACAATACGATTGCCATCATTACAGC
GGGGCCGCTGGCAAAAGATTTATCTGACAGGTACGGAATCGACAACAGGAAATCGGCGAGCATCCTTGATATTTTTTCCT
GTGCGGTTCAAGGATTGATTCCTTACGGTGCACAAATGCTGTCAGCTGCACAAATCGCGAAAATATCGCCTATCAGCATC
CTTCCTTATTCTTTTTATCCGATTTTAATCGGCGTCTGCGGCATTTGCGCGATTATCTTCAGACTGCCTCGCTTTACAGA
AAAAGCGTAA

Upstream 100 bases:

>100_bases
CTCCAGAACTTATTTTACCATTTGACTTTTGCGCGTGCGCCTTTTAAAGTGTTGGATATTGGTGAAAAAACGGTTTGAAC
CTACAGAAGAGGTGTACATC

Downstream 100 bases:

>100_bases
CTCTATAAGAAAGGCTGCCGTTATCAAACGGCAGCCTTTTTATCCCTCTGTTTCTGTCGCGTCCAGCTCCGCAAGCCTTT
CCATGATGCGCCGCTTTTTA

Product: hypothetical protein

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MQNQNGKASGLLPLFLFVCLFVGSGLITGDFYSLPIVAAALAASVVSLAMNRKEKLSQKTEWFAKGAGHPDIMIMVMIFI
LAGAFSSAAKAMGAVESTVNLALSFVPGQFMVAGLFIIAAFISVSMGTSTGTIAALAPIAAGISAEIGVPAAYSVAAVVG
GAMFGDNLSFISDTTIAAVRTQKTKMSDKFKTNFLIVLPAAVATVILLMVFSAGGHPGAQAGTYSWVKVLPYLGVLIFAL
LGFNVMAVIFGGIVLAGVIGISDGSLTLHTYLTAITEGIGGMSELIILSLLIGGMAEMMKRNGGIAFLLQFVSRRIRSKK
GAEAGIAGLVSAANLATANNTIAIITAGPLAKDLSDRYGIDNRKSASILDIFSCAVQGLIPYGAQMLSAAQIAKISPISI
LPYSFYPILIGVCGICAIIFRLPRFTEKA

Sequences:

>Translated_429_residues
MQNQNGKASGLLPLFLFVCLFVGSGLITGDFYSLPIVAAALAASVVSLAMNRKEKLSQKTEWFAKGAGHPDIMIMVMIFI
LAGAFSSAAKAMGAVESTVNLALSFVPGQFMVAGLFIIAAFISVSMGTSTGTIAALAPIAAGISAEIGVPAAYSVAAVVG
GAMFGDNLSFISDTTIAAVRTQKTKMSDKFKTNFLIVLPAAVATVILLMVFSAGGHPGAQAGTYSWVKVLPYLGVLIFAL
LGFNVMAVIFGGIVLAGVIGISDGSLTLHTYLTAITEGIGGMSELIILSLLIGGMAEMMKRNGGIAFLLQFVSRRIRSKK
GAEAGIAGLVSAANLATANNTIAIITAGPLAKDLSDRYGIDNRKSASILDIFSCAVQGLIPYGAQMLSAAQIAKISPISI
LPYSFYPILIGVCGICAIIFRLPRFTEKA
>Mature_429_residues
MQNQNGKASGLLPLFLFVCLFVGSGLITGDFYSLPIVAAALAASVVSLAMNRKEKLSQKTEWFAKGAGHPDIMIMVMIFI
LAGAFSSAAKAMGAVESTVNLALSFVPGQFMVAGLFIIAAFISVSMGTSTGTIAALAPIAAGISAEIGVPAAYSVAAVVG
GAMFGDNLSFISDTTIAAVRTQKTKMSDKFKTNFLIVLPAAVATVILLMVFSAGGHPGAQAGTYSWVKVLPYLGVLIFAL
LGFNVMAVIFGGIVLAGVIGISDGSLTLHTYLTAITEGIGGMSELIILSLLIGGMAEMMKRNGGIAFLLQFVSRRIRSKK
GAEAGIAGLVSAANLATANNTIAIITAGPLAKDLSDRYGIDNRKSASILDIFSCAVQGLIPYGAQMLSAAQIAKISPISI
LPYSFYPILIGVCGICAIIFRLPRFTEKA

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 44398; Mature: 44398

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCC
>Mature Secondary Structure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HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]