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The map label for this gene is mntH [H]

Identifier: 52784346

GI number: 52784346

Start: 532146

End: 533426

Strand: Reverse

Name: mntH [H]

Synonym: BLi00526

Alternate gene names: 52784346

Gene position: 533426-532146 (Counterclockwise)

Preceding gene: 52784347

Following gene: 52784345

Centisome position: 12.63

GC content: 48.87

Gene sequence:

>1281_bases
ATGGTCAGTCACGATTTGTCCAAACACTCGCAAATATCAAAAGAAGCCCAAGATGCACTGGATGGAAAAAGCAAAGGCTT
CAAAAGGCTGCTCCCTTTTTTGGGTCCGGCGTTTATCGCGGCTATAGCCTATATTGATCCAGGCAATTTCGCCACAAATA
TCGCGGCTGGTTCGAAATACGGCTACTTGCTTTTATGGGTAATCCTTTTTTCAAATATTATGGCTTTGCTGATTCAGTCA
TTGTCAGCCAAACTGGGAATTGCAACGGGTAAAAACCTGCCCGAAGTCGCCCGGGAAGAATTCCCCAAACCGGTCTCCAT
CGGCTTGTGGATTCAGGGAGAGCTTGTCGTGATCGCGACGGACTTGGCCGAATTTATCGGAGCTGCTCTCGGGCTCTACT
TGCTGTTCGGCATACCGATGCTTGAAGCATCGATTATTGCTGCCGCCGGATCTTTCGCCATTTTGGAACTGCAAAGGCGC
GGCGTCAGACCGCTTGAAGCGGCGATAACAGGAATGCTTTTCATCGTCGTGATCGCATTTGCCTTTCAAACGTTTTTTGC
AAAACCTGATATCGGATCGGTTTTGGAGGGCATGTTTGTCCCCCGCTTCGATGGTGCTGACAGCATCCTGCTGGCGGCGG
GAATCTTGGGAGCGACGGTGATGCCGCATGCCATCTATCTTCATTCCGCTCTCACACAGCGAAGAGTGGTCGGAAAAACG
GAAGCGGAAAAGAAAAAGATATTCCGCTTTGAGTTCATCGACATTTTGATCGCCATGCTGATTGCCGGAGCAATCAATGC
GAGCATGCTGATCGTAGCCGCTGCACTGTTTTATAAGAACGGCATTTTCGTCGAAGACCTTGATGTGGCCTTCAGCCACT
TCAGCAGCATGGTCAGTCCGCTTTCCGCCGTATTGTTCGGCGTCGGCCTGTTAACAGCCGGTTTATCAAGTTCGTCTGTC
GGAACGCTTTCAGGAGATATTATCATGCAGGGCTTCATTAATTTCAGGATTCCGCTTTATTTAAGACGGTTCATTACGAT
TTTGCCGCCGATCGCTATTATTGCTTCAGGGGTGAATCCGACAACCGCTCTTGTCTTGAGCCAGGTCGTCCTGTCATTCG
GCATCGCCTTTGCCCTTATCCCGCTTATCTTATTTACGAGCAATAAACGCATTATGGGGAGCCTGAAAAATGCAAAGTGG
ATAACAGCCGTCTCATGGCTGATCGCTGCCTTAATCGTCGCCCTCAATATTTTCCTGATTTACGATACATTTTCTGGTTA
A

Upstream 100 bases:

>100_bases
GTTGACAATTGATCATTGCGGGCATATGATGATGATATAAATTTGCACTAAGGAAACTTTTATGTACAAGGAAAAACAAC
TGAGAATATAGGTGAATAAA

Downstream 100 bases:

>100_bases
AAGTCGGCCTCGGTCGGCTTTTTTATATTATACTGAGAAAAAGGGGGATTCTGGATGTTTAAATTAATGGTACGTGATGA
TCTGTATTTAAAAATGCTCG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MVSHDLSKHSQISKEAQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNIAAGSKYGYLLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVVIATDLAEFIGAALGLYLLFGIPMLEASIIAAAGSFAILELQRR
GVRPLEAAITGMLFIVVIAFAFQTFFAKPDIGSVLEGMFVPRFDGADSILLAAGILGATVMPHAIYLHSALTQRRVVGKT
EAEKKKIFRFEFIDILIAMLIAGAINASMLIVAAALFYKNGIFVEDLDVAFSHFSSMVSPLSAVLFGVGLLTAGLSSSSV
GTLSGDIIMQGFINFRIPLYLRRFITILPPIAIIASGVNPTTALVLSQVVLSFGIAFALIPLILFTSNKRIMGSLKNAKW
ITAVSWLIAALIVALNIFLIYDTFSG

Sequences:

>Translated_426_residues
MVSHDLSKHSQISKEAQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNIAAGSKYGYLLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVVIATDLAEFIGAALGLYLLFGIPMLEASIIAAAGSFAILELQRR
GVRPLEAAITGMLFIVVIAFAFQTFFAKPDIGSVLEGMFVPRFDGADSILLAAGILGATVMPHAIYLHSALTQRRVVGKT
EAEKKKIFRFEFIDILIAMLIAGAINASMLIVAAALFYKNGIFVEDLDVAFSHFSSMVSPLSAVLFGVGLLTAGLSSSSV
GTLSGDIIMQGFINFRIPLYLRRFITILPPIAIIASGVNPTTALVLSQVVLSFGIAFALIPLILFTSNKRIMGSLKNAKW
ITAVSWLIAALIVALNIFLIYDTFSG
>Mature_426_residues
MVSHDLSKHSQISKEAQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNIAAGSKYGYLLLWVILFSNIMALLIQS
LSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVVIATDLAEFIGAALGLYLLFGIPMLEASIIAAAGSFAILELQRR
GVRPLEAAITGMLFIVVIAFAFQTFFAKPDIGSVLEGMFVPRFDGADSILLAAGILGATVMPHAIYLHSALTQRRVVGKT
EAEKKKIFRFEFIDILIAMLIAGAINASMLIVAAALFYKNGIFVEDLDVAFSHFSSMVSPLSAVLFGVGLLTAGLSSSSV
GTLSGDIIMQGFINFRIPLYLRRFITILPPIAIIASGVNPTTALVLSQVVLSFGIAFALIPLILFTSNKRIMGSLKNAKW
ITAVSWLIAALIVALNIFLIYDTFSG

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=443, Percent_Identity=30.2483069977427, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI295293167, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI295293171, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI295293169, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI295293175, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293173, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI10835169, Length=434, Percent_Identity=32.258064516129, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293178, Length=434, Percent_Identity=32.258064516129, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=49.5, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI193210616, Length=461, Percent_Identity=30.8026030368764, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71999499, Length=453, Percent_Identity=31.3465783664459, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17569473, Length=399, Percent_Identity=33.0827067669173, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71993856, Length=239, Percent_Identity=35.1464435146443, Blast_Score=160, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6323062, Length=398, Percent_Identity=31.9095477386935, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321841, Length=433, Percent_Identity=31.4087759815243, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324450, Length=444, Percent_Identity=31.3063063063063, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24648607, Length=434, Percent_Identity=31.5668202764977, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI281362176, Length=434, Percent_Identity=31.5668202764977, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24648609, Length=434, Percent_Identity=31.5668202764977, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI45553443, Length=411, Percent_Identity=32.360097323601, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45662; Mature: 45662

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSHDLSKHSQISKEAQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNIAAGSKY
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCH
GYLLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVVIAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCEEEEHH
DLAEFIGAALGLYLLFGIPMLEASIIAAAGSFAILELQRRGVRPLEAAITGMLFIVVIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AFQTFFAKPDIGSVLEGMFVPRFDGADSILLAAGILGATVMPHAIYLHSALTQRRVVGKT
HHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEKKKIFRFEFIDILIAMLIAGAINASMLIVAAALFYKNGIFVEDLDVAFSHFSSMVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
LSAVLFGVGLLTAGLSSSSVGTLSGDIIMQGFINFRIPLYLRRFITILPPIAIIASGVNP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCH
TTALVLSQVVLSFGIAFALIPLILFTSNKRIMGSLKNAKWITAVSWLIAALIVALNIFLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YDTFSG
EECCCC
>Mature Secondary Structure
MVSHDLSKHSQISKEAQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNIAAGSKY
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCH
GYLLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFPKPVSIGLWIQGELVVIAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCEEEEHH
DLAEFIGAALGLYLLFGIPMLEASIIAAAGSFAILELQRRGVRPLEAAITGMLFIVVIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AFQTFFAKPDIGSVLEGMFVPRFDGADSILLAAGILGATVMPHAIYLHSALTQRRVVGKT
HHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEKKKIFRFEFIDILIAMLIAGAINASMLIVAAALFYKNGIFVEDLDVAFSHFSSMVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
LSAVLFGVGLLTAGLSSSSVGTLSGDIIMQGFINFRIPLYLRRFITILPPIAIIASGVNP
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCH
TTALVLSQVVLSFGIAFALIPLILFTSNKRIMGSLKNAKWITAVSWLIAALIVALNIFLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YDTFSG
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146 [H]