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The map label for this gene is glmU [H]

Identifier: 52783907

GI number: 52783907

Start: 60864

End: 62264

Strand: Direct

Name: glmU [H]

Synonym: BLi00063

Alternate gene names: 52783907

Gene position: 60864-62264 (Clockwise)

Preceding gene: 52783906

Following gene: 52783908

Centisome position: 1.44

GC content: 47.11

Gene sequence:

>1401_bases
ATGGATAATAGGGATAATGGAGGCCAATACATGGATAAGCGGTTTGCAGTTGTGTTAGCAGCTGGTCAAGGAACAAGAAT
GAAATCAAAGCTATATAAAGTTCTTCATCCTGTTTGCGGAAAACCTATGGTCGAGCATGTTGTCGATGAAGCTCGCAAGC
TATCATTAGAAAAACTTGTCACAATAGTTGGACATGGTGCGGAAGATGTCAAAAAACAGCTCGGGGAAAAAAGCGAATAT
GCCCTGCAGGCTGAACAGCTCGGCACGGCCCATGCCGTCAAGCAGGCCAAGTCGATTCTTGGAAGCGAAAAAGGAACAAC
AATCGTCATCTGCGGAGATACCCCGCTTTTAACTGCCGAAACGATGGAAGCCATGCTCACGGAGCATCAGAAAAAAGCAG
CAAAGGTGACGATTTTAACCGCTGTAGCGGAAGATCCGACAGGCTACGGACGCATTATTCGCAATGAAAACGGCGATGTT
GCAAAGATTGTCGAACACAAAGATGCAACAGAAGAGGAAAGGCTTGTCAAAGAAATCAACACAGGCACCTACTGTTTTGA
CAACGAAGCTCTTTTTCAAACGATCGAGCAGGTTTCCAATGACAACGTACAGGGGGAATATTATCTTCCGGATGTCATTG
AGATCTTGAAAAATCAAGGTGAAACTGTAGCCGCTTATCAGACTGTCAACTTCCAGGAAACGCTCGGAGTCAATGACAGA
GTCGCCCTATCACAAGCGGAAATCTATATGAAGCAGCGGATCAATAAACGCCACATGCAGAACGGCGTCAGCTTAATCGA
TCCCGACAACACATACATTTCACCGGAAGCCGTGATCGGCAGGGATACCGTGATTTATCCCGGCACCGTCATTAAAGGGC
GGGTTGTTATCGGTGAAGACGCGGTCATCGGACAGAACAGCGAACTGGAAAACAGTACGGTCGGCAGCAGAACGGTCATT
AAGCAGTCCGTTATCGTGGACAGTGAAGTCGGCGACGATGTTACAATCGGACCGTTTGCTCATATCAGGCCCGACTCAAA
GATCGGCAATGAGGTAAGGATCGGGAATTTCGTCGAAGTGAAAAAATCGGAATTTGGTGATCGCAGCAAAGCATCTCATT
TAAGCTACATAGGGGACGCGGAAATCGGAACGGATGTCAATCTCGGCTGCGGGTCGATTACCGTAAATTATGATGGGAAA
CATAAGTTTAAAACGAAAATTGAAAATGGGGCATTTATCGGCTGCAACTCCAATTTGGTCGCTCCGGTGACAATCGGCGA
AGGCGCATACGTAGCTGCGGGTTCAACGATTACCGACGATGTGCCAGGCCGGGCTTTGTCTATTGCCAGAGCAAGACAAG
TCAATAAGGAAGACTACGCTGAGAACATACACAAAAAATAA

Upstream 100 bases:

>100_bases
TCCTAAATATGCTCTAAACATCCAAAATATGCTGTCTTGATTTCCCGATTTCTCATTTTGGCTTGCTTGAAATCAACTCA
TATTTAGGATATATTTTTCT

Downstream 100 bases:

>100_bases
TCCTAAATCGGAGGTTTACCATGTCTAAATATGAAGACGACAATTTGAAGATTTTTTCTTTAAACTCAAATCCGGGTCTT
GCGAAGGAAATCGCGGATAT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDNRDNGGQYMDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEARKLSLEKLVTIVGHGAEDVKKQLGEKSEY
ALQAEQLGTAHAVKQAKSILGSEKGTTIVICGDTPLLTAETMEAMLTEHQKKAAKVTILTAVAEDPTGYGRIIRNENGDV
AKIVEHKDATEEERLVKEINTGTYCFDNEALFQTIEQVSNDNVQGEYYLPDVIEILKNQGETVAAYQTVNFQETLGVNDR
VALSQAEIYMKQRINKRHMQNGVSLIDPDNTYISPEAVIGRDTVIYPGTVIKGRVVIGEDAVIGQNSELENSTVGSRTVI
KQSVIVDSEVGDDVTIGPFAHIRPDSKIGNEVRIGNFVEVKKSEFGDRSKASHLSYIGDAEIGTDVNLGCGSITVNYDGK
HKFKTKIENGAFIGCNSNLVAPVTIGEGAYVAAGSTITDDVPGRALSIARARQVNKEDYAENIHKK

Sequences:

>Translated_466_residues
MDNRDNGGQYMDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEARKLSLEKLVTIVGHGAEDVKKQLGEKSEY
ALQAEQLGTAHAVKQAKSILGSEKGTTIVICGDTPLLTAETMEAMLTEHQKKAAKVTILTAVAEDPTGYGRIIRNENGDV
AKIVEHKDATEEERLVKEINTGTYCFDNEALFQTIEQVSNDNVQGEYYLPDVIEILKNQGETVAAYQTVNFQETLGVNDR
VALSQAEIYMKQRINKRHMQNGVSLIDPDNTYISPEAVIGRDTVIYPGTVIKGRVVIGEDAVIGQNSELENSTVGSRTVI
KQSVIVDSEVGDDVTIGPFAHIRPDSKIGNEVRIGNFVEVKKSEFGDRSKASHLSYIGDAEIGTDVNLGCGSITVNYDGK
HKFKTKIENGAFIGCNSNLVAPVTIGEGAYVAAGSTITDDVPGRALSIARARQVNKEDYAENIHKK
>Mature_466_residues
MDNRDNGGQYMDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEARKLSLEKLVTIVGHGAEDVKKQLGEKSEY
ALQAEQLGTAHAVKQAKSILGSEKGTTIVICGDTPLLTAETMEAMLTEHQKKAAKVTILTAVAEDPTGYGRIIRNENGDV
AKIVEHKDATEEERLVKEINTGTYCFDNEALFQTIEQVSNDNVQGEYYLPDVIEILKNQGETVAAYQTVNFQETLGVNDR
VALSQAEIYMKQRINKRHMQNGVSLIDPDNTYISPEAVIGRDTVIYPGTVIKGRVVIGEDAVIGQNSELENSTVGSRTVI
KQSVIVDSEVGDDVTIGPFAHIRPDSKIGNEVRIGNFVEVKKSEFGDRSKASHLSYIGDAEIGTDVNLGCGSITVNYDGK
HKFKTKIENGAFIGCNSNLVAPVTIGEGAYVAAGSTITDDVPGRALSIARARQVNKEDYAENIHKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=41.3716814159292, Blast_Score=345, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17509979, Length=334, Percent_Identity=25.748502994012, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=318, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=352, Percent_Identity=21.0227272727273, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355443, Length=345, Percent_Identity=24.3478260869565, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24644084, Length=345, Percent_Identity=24.3478260869565, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 50738; Mature: 50738

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRDNGGQYMDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEARKLSLEKLV
CCCCCCCCHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TIVGHGAEDVKKQLGEKSEYALQAEQLGTAHAVKQAKSILGSEKGTTIVICGDTPLLTAE
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
TMEAMLTEHQKKAAKVTILTAVAEDPTGYGRIIRNENGDVAKIVEHKDATEEERLVKEIN
HHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCEEEHHHCCCCCHHHHHHHHHC
TGTYCFDNEALFQTIEQVSNDNVQGEYYLPDVIEILKNQGETVAAYQTVNFQETLGVNDR
CCCEEECCHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEECCHHHHCCCCCC
VALSQAEIYMKQRINKRHMQNGVSLIDPDNTYISPEAVIGRDTVIYPGTVIKGRVVIGED
EEHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCEECCCEEEECCCEEEEEEEECCC
AVIGQNSELENSTVGSRTVIKQSVIVDSEVGDDVTIGPFAHIRPDSKIGNEVRIGNFVEV
EEECCCCCCCCCCCCCHHHHHHHHEEECCCCCCEEECCCEEECCCCCCCCEEECCCEEEE
KKSEFGDRSKASHLSYIGDAEIGTDVNLGCGSITVNYDGKHKFKTKIENGAFIGCNSNLV
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCEEEECCCCEE
APVTIGEGAYVAAGSTITDDVPGRALSIARARQVNKEDYAENIHKK
EEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MDNRDNGGQYMDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEARKLSLEKLV
CCCCCCCCHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TIVGHGAEDVKKQLGEKSEYALQAEQLGTAHAVKQAKSILGSEKGTTIVICGDTPLLTAE
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
TMEAMLTEHQKKAAKVTILTAVAEDPTGYGRIIRNENGDVAKIVEHKDATEEERLVKEIN
HHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCEEEHHHCCCCCHHHHHHHHHC
TGTYCFDNEALFQTIEQVSNDNVQGEYYLPDVIEILKNQGETVAAYQTVNFQETLGVNDR
CCCEEECCHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEECCHHHHCCCCCC
VALSQAEIYMKQRINKRHMQNGVSLIDPDNTYISPEAVIGRDTVIYPGTVIKGRVVIGED
EEHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCEECCCEEEECCCEEEEEEEECCC
AVIGQNSELENSTVGSRTVIKQSVIVDSEVGDDVTIGPFAHIRPDSKIGNEVRIGNFVEV
EEECCCCCCCCCCCCCHHHHHHHHEEECCCCCCEEECCCEEECCCCCCCCEEECCCEEEE
KKSEFGDRSKASHLSYIGDAEIGTDVNLGCGSITVNYDGKHKFKTKIENGAFIGCNSNLV
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCEEEECCCCEE
APVTIGEGAYVAAGSTITDDVPGRALSIARARQVNKEDYAENIHKK
EEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA