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The map label for this gene is guaC [H]

Identifier: 52145262

GI number: 52145262

Start: 5266465

End: 5267448

Strand: Direct

Name: guaC [H]

Synonym: BCZK5151

Alternate gene names: 52145262

Gene position: 5266465-5267448 (Clockwise)

Preceding gene: 52145259

Following gene: 52145263

Centisome position: 99.35

GC content: 36.79

Gene sequence:

>984_bases
ATGGAAAACGTATTCGACTATGAAGATATTCAATTAATTCCTGCAAAATGTATTGTAAATAGCCGCTCTGAATGTGATAC
AACTGTCACTTTAGGAAAACATAAATTTAAATTACCTGTCGTACCTGCAAATATGCAAACGATTATTGATGAAAGAATTG
CAACTTATTTAGCTGAAAATAATTACTTCTATATCATGCATCGTTTCCAACCAGAGAAACGAATCTCATTCATTAGAGAT
ATGCAATCACGTGGATTAATTGCTTCTATTAGCGTTGGTGTAAAAGAAGACGAGTATGAATTCGTGCAACAATTAGCTGC
TGAGCATCTTACGCCTGAATACATCACAATTGATATCGCGCATGGACATTCTAATGCTGTAATCAACATGATTCAACATA
TTAAAAAGCATTTACCAGAAAGCTTCGTTATCGCTGGAAACGTTGGAACTCCAGAAGCGGTAAGAGAATTAGAAAACGCT
GGTGCTGATGCAACAAAAGTTGGTATTGGACCTGGTAAAGTTTGTATTACTAAAATTAAAACAGGATTTGGAACTGGCGG
TTGGCAACTAGCTGCACTTCGCTGGTGTGCAAAAGCTGCAAGTAAGCCAATTATCGCTGACGGTGGTATCCGTACAAACG
GTGACGTAGCTAAATCTATTCGATTTGGGGCGACTATGGTTATGATCGGTTCTCTATTCGCTGGTCATGAAGAGTCTCCA
GGGGAAACAATCGAAAAAGATGGTAAACTTTATAAAGAGTACTTCGGTTCAGCTTCTGAATTCCAAAAAGGTGAGAAGAA
AAATGTTGAAGGTAAGAAAATGTTCGTTGAGCATAAAGGTTCTTTAGAAGACACTTTAATCGAAATGGAACAAGATCTTC
AATCTTCTATCTCTTACGCTGGTGGAACAAAATTAGACTCAATTCGTACTGTAGATTATGTAGTCGTAAAAAACTCTATT
TTCAACGGTGATAAAGTATATTAA

Upstream 100 bases:

>100_bases
GAAAACCTTTGACTTATGAGTGAAAATAATGTAAATTATCTTTTGGACGAACATTTTTAAACAAAATGAATAAAATATTC
GTATTTTAGGGGTGTAAATG

Downstream 100 bases:

>100_bases
TTTTTAAACTTAACTCGAAGGACAAGCATTTTTATGCTTGTCTTTTTTCATATATAGAAATGTAAAATATTTTCATTTTA
CTGAATTTTCTAGTATCATG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIRD
MQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESP
GETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNSI
FNGDKVY

Sequences:

>Translated_327_residues
MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIRD
MQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESP
GETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNSI
FNGDKVY
>Mature_327_residues
MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIRD
MQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESP
GETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNSI
FNGDKVY

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541952, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541948, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541956, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI156104880, Length=338, Percent_Identity=31.0650887573964, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI66933016, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI217035146, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI217035148, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI217035150, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI217035152, Length=252, Percent_Identity=32.9365079365079, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI156616279, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI34328928, Length=252, Percent_Identity=32.5396825396825, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI34328930, Length=252, Percent_Identity=32.9365079365079, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=31.4540059347181, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788855, Length=294, Percent_Identity=34.3537414965986, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=324, Percent_Identity=31.7901234567901, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71994389, Length=151, Percent_Identity=38.4105960264901, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994385, Length=151, Percent_Identity=38.4105960264901, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=252, Percent_Identity=31.3492063492063, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322012, Length=210, Percent_Identity=32.8571428571429, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319352, Length=136, Percent_Identity=30.8823529411765, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28571163, Length=250, Percent_Identity=32.4, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=253, Percent_Identity=32.0158102766798, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641073, Length=253, Percent_Identity=32.0158102766798, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001295
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 36149; Mature: 36149

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00487 IMP_DH_GMP_RED ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAEN
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHHHCC
NYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIA
CEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEE
HGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIK
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
TGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESP
CCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYA
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
GGTKLDSIRTVDYVVVKNSIFNGDKVY
CCCCCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAEN
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHHHCC
NYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIA
CEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEE
HGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIK
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
TGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESP
CCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYA
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
GGTKLDSIRTVDYVVVKNSIFNGDKVY
CCCCCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA