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The map label for this gene is nanT [C]

Identifier: 52145250

GI number: 52145250

Start: 5253004

End: 5254302

Strand: Direct

Name: nanT [C]

Synonym: BCZK5139

Alternate gene names: 52145250

Gene position: 5253004-5254302 (Clockwise)

Preceding gene: 52145243

Following gene: 52145253

Centisome position: 99.1

GC content: 37.88

Gene sequence:

>1299_bases
ATGAACGTCACTACTGATGTACAATCAACAACAGAGGAGACGAAAGAGAAAAGATATAAAACATTATTTGGTTCTGCGCT
AGGATATGCAGCAGAAGGTTTAGATATGTTGCTCTTATCTTTCGTACTCGTCTACATTTTAAAAGAATTTCATTTAAGCC
CTGTTGAAGGTGGAAACTTAACATTAGCTACTACCATAGGAATGCTGATCGGGTCTTATTTATTTGGATTTATTGCTGAT
TTATTCGGCCGTATCCGTACGATGGCCTTTACAATCTTACTATTTTCATTAGCGACAGCACTTATTTATTTCGCGACAGA
TTATTGGCAATTATTAATTCTTCGCTTTTTAGTTGGAATGGGAGTTGGTGGTGAGTTCGGAATTGGAATGGCCATCGTAA
CTGAAACATGGTCTAAAGAAATGCGCGCAAAGGCGACATCAGTTGTTGCACTTGGATGGCAATTTGGCGTATTAGTTGCT
TCACTCCTACCAGCATTTATCGTTCCGCATTTTGGATGGAGAGCGGTGTTCTTATTTGGACTCATTCCCGCTTTACTTGC
TGTCTATGTCCGTAAGAGTTTAAGTGAACCGAAAATATGGGAACAAAAGCAACGATACAAAAAAGAATTGTTACAAAAAG
AAGCTGAAGGTAATTTAACAACTACTGAGGCAGAGCAATTAAAGCAAATGAAAAAGTTCCCACTTCGAAAGTTATTTGCA
AATAAAAAAGTAACGATAACAACAATTGGTCTTATTATTATGTCATTCATCCAAAACTTCGGATATTATGGAATTTTCAC
ATGGATGCCAACCATTTTAGCGAATAAATATAACTACACATTAGCAAAAGCGAGCGGTTGGATGTTCATCTCTACGATCG
GCATGCTCATTGGAATTGCAACTTTTGGTATTCTAGCTGATAAAATTGGTCGCCGTAAAACTTTTACAATCTATTATGTC
GGTGGTACTATATACTGTCTCATTTACTTCTTCTTATTCACAGATTCAACATTATTGTTATGGGGAAGTGCATTGCTTGG
ATTCTTTGCCAATGGCATGATGGGAGGATTCGGGGCAGTTTTAGCCGAAAACTATCCTGCTGAAGCTCGCTCTACAGCAG
AAAACTTTATTTTCGGTACAGGACGTGGTTTAGCTGGATTTGGGCCTGTTATTATCGGCTTACTTGCTGCAGGCGGTAAT
TTAATGGGAGCATTATCTCTCATCTTCATTATCTATCCAATCGGTTTAGTTACGATGTTATTATGTGTTCCAGAGACGAA
AGATAAAGTATTAGAATAG

Upstream 100 bases:

>100_bases
AGAAATACGTATGCTTTTTTGGCCTTCTCATCATATCAGGTGAGAAGGCCTTTTGTTATTCTTCCATAGCGACTGTAGAA
GAAAATAAGGAGGAATAATG

Downstream 100 bases:

>100_bases
ATTGAAACTGTATCCTTCAAAAAAATAGTTGGATAAATAGGAAAGAGGAAGTATCTCAAATGAGATGCTTCCTCTTTTTA
TATAAATACAATTATTTACT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIAD
LFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLVA
SLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKEAEGNLTTTEAEQLKQMKKFPLRKLFA
NKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYYV
GGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGGN
LMGALSLIFIIYPIGLVTMLLCVPETKDKVLE

Sequences:

>Translated_432_residues
MNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIAD
LFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLVA
SLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKEAEGNLTTTEAEQLKQMKKFPLRKLFA
NKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYYV
GGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGGN
LMGALSLIFIIYPIGLVTMLLCVPETKDKVLE
>Mature_432_residues
MNVTTDVQSTTEETKEKRYKTLFGSALGYAAEGLDMLLLSFVLVYILKEFHLSPVEGGNLTLATTIGMLIGSYLFGFIAD
LFGRIRTMAFTILLFSLATALIYFATDYWQLLILRFLVGMGVGGEFGIGMAIVTETWSKEMRAKATSVVALGWQFGVLVA
SLLPAFIVPHFGWRAVFLFGLIPALLAVYVRKSLSEPKIWEQKQRYKKELLQKEAEGNLTTTEAEQLKQMKKFPLRKLFA
NKKVTITTIGLIIMSFIQNFGYYGIFTWMPTILANKYNYTLAKASGWMFISTIGMLIGIATFGILADKIGRRKTFTIYYV
GGTIYCLIYFFLFTDSTLLLWGSALLGFFANGMMGGFGAVLAENYPAEARSTAENFIFGTGRGLAGFGPVIIGLLAAGGN
LMGALSLIFIIYPIGLVTMLLCVPETKDKVLE

Specific function: May Be A Sugar-Cation Symporter Involved In Sialic Acid Transport As It Is Required For Sialic Acid Uptake. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=401, Percent_Identity=24.9376558603491, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI7662270, Length=320, Percent_Identity=22.5, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI216548223, Length=126, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI262399383, Length=260, Percent_Identity=21.9230769230769, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI213021148, Length=446, Percent_Identity=24.2152466367713, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082231, Length=452, Percent_Identity=25.8849557522124, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87082404, Length=375, Percent_Identity=26.9333333333333, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790550, Length=442, Percent_Identity=25.5656108597285, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788068, Length=345, Percent_Identity=24.9275362318841, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081723, Length=380, Percent_Identity=25.2631578947368, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788292, Length=368, Percent_Identity=27.445652173913, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786229, Length=255, Percent_Identity=26.2745098039216, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789152, Length=449, Percent_Identity=23.6080178173719, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082159, Length=249, Percent_Identity=23.6947791164659, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788942, Length=343, Percent_Identity=24.7813411078717, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=445, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640198, Length=291, Percent_Identity=26.4604810996564, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640196, Length=291, Percent_Identity=26.4604810996564, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640200, Length=291, Percent_Identity=26.4604810996564, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47734; Mature: 47734

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCHHHHCCC
>Mature Secondary Structure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HHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]