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The map label for this gene is lytR [H]

Identifier: 52145248

GI number: 52145248

Start: 5250188

End: 5250928

Strand: Reverse

Name: lytR [H]

Synonym: BCZK5137

Alternate gene names: 52145248

Gene position: 5250928-5250188 (Counterclockwise)

Preceding gene: 52145249

Following gene: 52145247

Centisome position: 99.06

GC content: 33.6

Gene sequence:

>741_bases
TTGTTAAAAGTACTAGTAGTTGATGATGAAATGTTAGCACGTGATGAACTAAAGTATTTATTAGAGAGAACGAAGGAAGT
TGAGATAATTGGTGAGGCTGATTGTGTAGAGGACGCATTAGAAGAGTTAATGAAAAACAAACCAGATATTGTTTTCCTAG
ATATTCAGTTATCGGATGATAACGGATTCGAAATCGCGAATATATTAAAGAAGATGAAAAATCCGCCTGCAATTGTATTT
GCGACTGCCTATGATCAATACGCGTTGCAAGCATTTGAAGTAGATGCGTTAGACTATATTTTAAAGCCATTTGATGAAGA
ACGTATTGTACAAACATTAAAGAAATATAAAAAACAAAAACAATCGCAAATAGAAATGAAGCAAGAAATAAAAGGGGCAG
ATGTAACGGCAGAGATGTATAAATTAGCATTACCAATTGAGGAATCGATTGTTCTTGTAAATATTGAAGATATTGTATAT
GTAGGGCTTGTGGACGGAAAAGTGACAGTAAAAACAATGAGGGAAACATATGTAACACACGATACGCTTGTAATTTTGGA
AAAGAAGTTGCCACAAGCAAGTTTCATGCGTGTCCATCGTAGCTTTATTGCAAATATTAATCATATTACTGAAATTCAGC
CATGGTTCAACTCTACTTATAATTTAATTATGAAAGAAGGATCAAAGGTACCTGTTAGTCGTACATATGCAAAAGAACTC
AAGAAGCTGCTTCGTATTTAA

Upstream 100 bases:

>100_bases
TTATTTGGGAAAGAAACGATGCTTCATATCGAAAGTGAAGTGAATGAGGGGACAGAGATTACTTTTGTTATTCCAAAAAA
AGTAGGGGAGGAAGAGCAGA

Downstream 100 bases:

>100_bases
GAAGCAGCTTTTGTATTTCATCCTTTTATATTTGTAACTGATTCTGTATATTTGACGTTCTGTTATGTAAACGCTTACTA
AAGCGGTTATATCCTATAAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMKNKPDIVFLDIQLSDDNGFEIANILKKMKNPPAIVF
ATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQKQSQIEMKQEIKGADVTAEMYKLALPIEESIVLVNIEDIVY
VGLVDGKVTVKTMRETYVTHDTLVILEKKLPQASFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKEL
KKLLRI

Sequences:

>Translated_246_residues
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMKNKPDIVFLDIQLSDDNGFEIANILKKMKNPPAIVF
ATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQKQSQIEMKQEIKGADVTAEMYKLALPIEESIVLVNIEDIVY
VGLVDGKVTVKTMRETYVTHDTLVILEKKLPQASFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKEL
KKLLRI
>Mature_246_residues
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMKNKPDIVFLDIQLSDDNGFEIANILKKMKNPPAIVF
ATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQKQSQIEMKQEIKGADVTAEMYKLALPIEESIVLVNIEDIVY
VGLVDGKVTVKTMRETYVTHDTLVILEKKLPQASFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKEL
KKLLRI

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=246, Percent_Identity=39.0243902439024, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI87082052, Length=249, Percent_Identity=35.7429718875502, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788222, Length=123, Percent_Identity=27.6422764227642, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28434; Mature: 28434

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMKNKPDIVFLDIQLSDD
CEEEEEECCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCC
NGFEIANILKKMKNPPAIVFATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQK
CCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QSQIEMKQEIKGADVTAEMYKLALPIEESIVLVNIEDIVYVGLVDGKVTVKTMRETYVTH
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEHHEEEEEEECCEEEEHHHHHHHHCC
DTLVILEKKLPQASFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKEL
HHEEEEEHHCCHHHHHHHHHHHHHCCHHHHCCCHHHCCHHHHHEECCCCCCCHHHHHHHH
KKLLRI
HHHHCC
>Mature Secondary Structure
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMKNKPDIVFLDIQLSDD
CEEEEEECCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCC
NGFEIANILKKMKNPPAIVFATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQK
CCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QSQIEMKQEIKGADVTAEMYKLALPIEESIVLVNIEDIVYVGLVDGKVTVKTMRETYVTH
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEHHEEEEEEECCEEEEHHHHHHHHCC
DTLVILEKKLPQASFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKEL
HHEEEEEHHCCHHHHHHHHHHHHHCCHHHHCCCHHHCCHHHHHEECCCCCCCHHHHHHHH
KKLLRI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]