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The map label for this gene is ykcC [H]

Identifier: 52145241

GI number: 52145241

Start: 5241309

End: 5242280

Strand: Direct

Name: ykcC [H]

Synonym: BCZK5129

Alternate gene names: 52145241

Gene position: 5241309-5242280 (Clockwise)

Preceding gene: 52145239

Following gene: 52145243

Centisome position: 98.88

GC content: 36.11

Gene sequence:

>972_bases
ATGCAAAAATTAATCTCGGTTGTAGTTCCTATGTACTTCGAGGAAGAAGTAGCACAGGAATGTTATAACCGTTTAAAGTC
CGTTATGCTTCAAAATGATATTAATTACGAGTTTGTCTTTGTAAACGACGGTAGTACAGATCGTACAATGGAAATCTTAT
CTGAGATTGCAGCAAATGATTACCGTACAAAAATCGTTAATTTCGCTCGTAACTTTGGTCACCAAGTAGCTGTTACAGCT
GGTATTGCTGCTGCAAAAGGTGATGCTATTGTAATTATAGATGCAGACTTACAAGATCCACCTGAAGTTATTCCTGAACT
TATTGCAAAATGGGAAGAAGGATATGAAGTTGTTTATGCAAAACGTAAGCAACGTAAAGGTGAAACTTGGTTTAAACTTT
TAACAGCTAAATATTTCTATAAGTTCTTAAACTACATGTCTGATATCGATATCCCAAAAGATACTGGTGATTTCCGCATC
ATCGATCGCAAAATAGCTGATGTTTTCAATCAAATGACTGAGCGAAATCGCTTCATCCGCGGTATGATGTCTTGGGTTGG
CTTCCGCCAAACGTATGTTGAATATGAACGCGACGAGCGCTTTGCTGGTGAAACAAAATATCCATTAAAGAAAATGATTA
AATTTGCATCTGATGGCATTATTGCATTTTCAACAAAGCCGTTACGTATCGTGATGACTTTAGGCTTATTATCAGTCCTC
ATTTCAATAATTGTTTTACTATATACAATCACTGTGAAAATTATCGGCACTGGTACACAAACAGGTTGGGCATCTATTAT
GGTTGCTATTACATTCTTTAGCGGTATTCAATTACTTGGTCTTGGAATCGTTGGTCAGTATATCGCTCGTATTTATGACG
AAAGTAAAAACCGTCCGATTTATATCGTAAAAGAAACAATCAACATTGACCAAGAAGAGACTGCACTGAAAAAAGAAAAA
GTGAATGCATAA

Upstream 100 bases:

>100_bases
GGTTATAAATTTTGTCCTTAATAAAATTTGGACATTCAACCAAACGGAAAAGGCTACTAATTAAACTGAAACAATTTATT
AAAAATACGGAGGATACAAC

Downstream 100 bases:

>100_bases
TAAAAAAGGTAACAATGAAAACTATCATTGTTACCTTTTTATATTGTAATAGCCCATAAGTCTCAAACGAAATTCTTTTA
AATTTGGATATACTTCTAAA

Product: glycosyltransferase, group 2 family protein

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKIADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMTLGLLSVL
ISIIVLLYTITVKIIGTGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA

Sequences:

>Translated_323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKIADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMTLGLLSVL
ISIIVLLYTITVKIIGTGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA
>Mature_323_residues
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAANDYRTKIVNFARNFGHQVAVTA
GIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYAKRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRI
IDRKIADVFNQMTERNRFIRGMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMTLGLLSVL
ISIIVLLYTITVKIIGTGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPIYIVKETINIDQEETALKKEK
VNA

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788692, Length=300, Percent_Identity=42.6666666666667, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1788588, Length=324, Percent_Identity=33.641975308642, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1787259, Length=92, Percent_Identity=36.9565217391304, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585265, Length=232, Percent_Identity=26.7241379310345, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 37045; Mature: 37045

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAAND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCH
YRTKIVNFARNFGHQVAVTAGIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYA
HHHHHHHHHHHCCCEEEEECCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
KRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRIIDRKIADVFNQMTERNRFIR
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMTLGLLSVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
ISIIVLLYTITVKIIGTGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPI
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
YIVKETINIDQEETALKKEKVNA
EEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQKLISVVVPMYFEEEVAQECYNRLKSVMLQNDINYEFVFVNDGSTDRTMEILSEIAAND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCH
YRTKIVNFARNFGHQVAVTAGIAAAKGDAIVIIDADLQDPPEVIPELIAKWEEGYEVVYA
HHHHHHHHHHHCCCEEEEECCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
KRKQRKGETWFKLLTAKYFYKFLNYMSDIDIPKDTGDFRIIDRKIADVFNQMTERNRFIR
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMMSWVGFRQTYVEYERDERFAGETKYPLKKMIKFASDGIIAFSTKPLRIVMTLGLLSVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
ISIIVLLYTITVKIIGTGTQTGWASIMVAITFFSGIQLLGLGIVGQYIARIYDESKNRPI
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
YIVKETINIDQEETALKKEKVNA
EEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]