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The map label for this gene is uvrB [H]

Identifier: 52145209

GI number: 52145209

Start: 4949635

End: 4951611

Strand: Reverse

Name: uvrB [H]

Synonym: BCZK4860

Alternate gene names: 52145209

Gene position: 4951611-4949635 (Counterclockwise)

Preceding gene: 52140398

Following gene: 52140399

Centisome position: 93.41

GC content: 39.86

Gene sequence:

>1977_bases
TTGAAACGTCAATTTGAAATTGTCTCAGCGTATTCCCCGCAAGGTGATCAGCCGGTAGCTATAGAGAAGCTTGTAGAGGG
AATTAATAGTGGAAAGAAAAAGCAAGTGTTGCTTGGGGCGACAGGAACGGGTAAGACATTTACGATTTCAAATGTCATTA
AAGAAGTGCAAAAGCCAACGCTTGTCATGGCTCACAATAAAACGTTAGCAGGACAGTTATATAGTGAGTTGAAAGACTTT
TTTCCGAATAATGCAGTTGAATATTTTGTTAGTTATTACGATTATTATCAGCCAGAAGCGTATGTGCCACAAACAGATAC
ATTTATTGAAAAAGACGCACAGATTAATGATGAAATTGATAAATTACGTCACTCAGCAACGTCTGCATTATTTGAACGGG
ATGATGTAATTATTGTTGCGAGTGTTTCATGTATATATGGTTTAGGTTCTCCAGAAGAATACCGCGAGTTAGTTGTTTCA
CTTCGAGTTGGTATGGAAAAGGACCGCAATCAATTGCTTCGTGAACTTGTTGATGTGCAGTATGGACGTAATGATATTGA
TTTCAAGCGTGGTACATTCCGTGTGCGCGGAGATGTAGTTGAAATCTTCCCGGCATCACTTGACGAGCATTGTATTCGAA
TTGAGTTTTTTGGCGATGAAATTGATCGTATTCGCGAAGTAAATGCTTTAACGGGGGAAGTATTAGCAGAACGTGATCAT
GTAGCAATCTTCCCAGCATCTCACTTCGTTACACGTGAAGAAAAGATGAAGGTCGCTATTGAAAATATCGAAAAAGAATT
AGAAGAGCGTTTAAAGGAATTAAATGATAACGGTAAGTTGTTAGAAGCGCAGCGTATAGAACAGCGTACACGTTATGATT
TAGAAATGATGCGCGAGATGGGCTTTTGTTCAGGGATTGAAAACTATTCCCGTCATTTAACACTTCGTCCAGCGGGTGCA
ACGCCGTATACGTTATTAGACTATTTCCCGGAAGATTTCTTAATCGTTATGGATGAGTCGCACGTATCAGTGCCACAAGT
AAGAGCGATGTATAACGGGGACCAAGCGCGTAAGCAAGTGCTTGTGGATCATGGATTCCGTCTTCCATCAGCTTTAGATA
ATAGACCGCTCACATTTGATGAGTTTGAAGAGAAAACGAATCAAGTTATTTACGTTTCAGCAACGCCAGGTCCGTATGAA
TTAGAGCAGTCGCCAGAAGTAATAGAACAAATTATTCGTCCAACAGGGCTTTTAGATCCGCCAATTGATATACGACCAAT
TGAAGGGCAGATTGACGATTTATTAGGAGAAATTCAAGATCGCATTGCAAAAAATGAACGTGTATTAATTACAACTTTAA
CGAAGAAGATGTCAGAGGATTTAACAGACTACTTAAAAGATGTAGGAATTAAGGTAAATTATCTGCATTCTGAAGTGAAA
ACGTTAGAACGTATTGAAATTATACGAGATCTTCGCCTTGGTAAGTTTGATGTTCTCGTTGGCATTAACTTATTGCGAGA
AGGATTAGATATTCCAGAAGTATCCCTTGTAGCTATTTTAGATGCTGATAAGGAAGGATTCTTGCGTTCAGAGCGTTCAT
TAATTCAAACAATTGGCCGTGCAGCACGTAATGAAAACGGCCGCGTTATTATGTACGCAGATCGTATAACGAGATCGATG
GGAATTGCGATTGAAGAAACACAGCGTCGTCGTAGTATACAAGAAGCTTACAATGAAGAGTATGGTATTACGCCAAAAAC
GATTCAAAAAGGTGTGCGTGATGTAATCCGTGCAACGACAGCTGCTGAAGAGCCGGAAACGTATGAAGCAACGCCAGCTA
AGAAGATGACGAAAAAAGAGCGTGAAAAGACAATTGCGAAGATGGAAGCAGAAATGAAAGAAGCAGCAAAAGCGTTAGAC
TTCGAGCGTGCAGCTGAATTAAGAGATTTACTATTAGAATTAAAAGCGGAAGGGTGA

Upstream 100 bases:

>100_bases
TGTCGAAAACTTTACCGAATATCTGTTCGTTTTTTTAGGTTTTTTATGGGCATTCGTGGTAAAATAATAATACAGATTTT
TATGAGGAGGTCGGATTTTT

Downstream 100 bases:

>100_bases
AAAGAGTGAGTAAGAGCAAGGATTTTATTGTTGTAAAAGGTGCTAGAGCACATAACTTAAAAAATATTGATGTAACCATT
CCGAGAAACCAACTTGTCGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MKRQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETQRRRSIQEAYNEEYGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG

Sequences:

>Translated_658_residues
MKRQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETQRRRSIQEAYNEEYGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG
>Mature_658_residues
MKRQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETQRRRSIQEAYNEEYGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=57.957957957958, Blast_Score=765, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75190; Mature: 75190

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPT
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHCCCE
LVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHH
KLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
CCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREM
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
GFCSGIENYSRHLTLRPAGATPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQV
HHHCCCCHHHCEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHH
LVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
PIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
CCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADRITRSMGIAIEETQRRRSIQEAYNEEYGITPKTIQKGVRDVIRATT
HHCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPT
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHCCCE
LVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHH
KLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
CCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREM
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
GFCSGIENYSRHLTLRPAGATPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQV
HHHCCCCHHHCEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHH
LVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
PIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
CCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADRITRSMGIAIEETQRRRSIQEAYNEEYGITPKTIQKGVRDVIRATT
HHCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]