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The map label for this gene is gntR [H]

Identifier: 52142912

GI number: 52142912

Start: 2461649

End: 2463019

Strand: Direct

Name: gntR [H]

Synonym: BCZK2329

Alternate gene names: 52142912

Gene position: 2461649-2463019 (Clockwise)

Preceding gene: 52142911

Following gene: 52142910

Centisome position: 46.44

GC content: 30.49

Gene sequence:

>1371_bases
ATGTATAAGTATTTACATATTTTAAACGATATAGAAAAAATGATTCAAAATGGAGCGATAAATGAAGGACAGAAATTACC
ATCAATACGGTCACTTGTTACGCAATATGAATGTAATAAGGCGACAGTTATACGTGCTCTTTATGAATTGGAAAAGCATC
ATATTATATATTCTGTCCCTCAAAGTGGATACTACGTTGTTAAAAAATCAGGGAGTACTATAGAAAATAACGAGATAATT
GATTTCGCTTCTTCAGCACCAGATCCAGATGTTTTCCCATATTTAGATTTTCAGCATTGCATTAATAAGGCTATTGATAC
TTATAAAAATGATTTGTTCGTATACGGAACACCGAAAGGGTTACCATCTTTAATTCCAGTCATTCAAAAACAGTTGGCAA
ATTATCAAGTGTTCACGAAAGAAGACAATATTTTTATAACGTCAGGTGTGCAGCAGGCACTTGCAATATTAACTTCTATA
CCATTTCCAAATGAAAATGAAACAATATTAGTTGAACAACCAACGTATCATTTATATATAGAGTATCTAGAAATAAATAA
AGTTCCTGTAATCGGTATTAAACGTACGAATGAAGGTATTGATTTAAAAGAATTGGAGCGTATTTTTCGAACTGGTAAAA
TAAAATTCTTTTATACAATACCAAGATATCATCATCCACTTGGAACTTCTTATTCTAAAGATGAGAAAGAAAAAATCGTA
CTATTGGCTAAGAAATATAATGTATTTATAGTGGAAGATGATTATTTAGCAGATTTAGAAACAGATTCAAAAGCTGATCC
ATTATATAGCCTGGATCATGGTAATCATGTCATATATTTAAAAAGTTATTCGAAAATTATTTTTCCAGGTTTACGAGTTG
GTGTAGCAGTTATTCCGCCGATTATTTCGAGTGCTTTCCATACATATAAAAAGGTTTTAGATATTGATAGCCCGATGATA
TCCCAAGCTGCTTTAGAAATTTATATAAAGAGTGGCATGTTCGAACGCCATAAAAATAAAATTCAATCTTCCTATAATAA
CAGATCTAAAAAACTAGCAGAAGTATTAGAAAGAATGTATAGTGAAAACCCGCTTTTATTCACACATAAAAAGCAAAATA
CAATTGGAATCCATACTTGTTTAGAAGTACATAAAACAAGTATTTCGGGCATGTTGATACAAAGACTAAGTGGAATGCAA
ATCAGTATTGATACGATTGATAAGAATTATGTGAGAGGTTTTCCGAAACAAAGACTATTAAAGTTGAACGTATCGAATGT
AAAGGAAGATAGGATTGAAGAAGGAATTCGTAAAATAATGGAGGAAATCAAACAAGTGGAACGTCTAAATTTTAAATTTA
AAAAAGAATAA

Upstream 100 bases:

>100_bases
TAAGATATAGAAAATCGGAAAATTAACTAATTGAGGAATGGATGGTATATAAATGAAAAGTCGATGTAATTAAATATAGA
ATTGCTGAAGGAGGTGTAAT

Downstream 100 bases:

>100_bases
AATGATATTTTTAGAGTACCCAATGGCTGAGTGCTCTTTTTATTTTGGATATAAGTAATTTAAATGGGAATTAACTACCA
ATAAATGTTAACCTTAAAGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: ORF8 [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MYKYLHILNDIEKMIQNGAINEGQKLPSIRSLVTQYECNKATVIRALYELEKHHIIYSVPQSGYYVVKKSGSTIENNEII
DFASSAPDPDVFPYLDFQHCINKAIDTYKNDLFVYGTPKGLPSLIPVIQKQLANYQVFTKEDNIFITSGVQQALAILTSI
PFPNENETILVEQPTYHLYIEYLEINKVPVIGIKRTNEGIDLKELERIFRTGKIKFFYTIPRYHHPLGTSYSKDEKEKIV
LLAKKYNVFIVEDDYLADLETDSKADPLYSLDHGNHVIYLKSYSKIIFPGLRVGVAVIPPIISSAFHTYKKVLDIDSPMI
SQAALEIYIKSGMFERHKNKIQSSYNNRSKKLAEVLERMYSENPLLFTHKKQNTIGIHTCLEVHKTSISGMLIQRLSGMQ
ISIDTIDKNYVRGFPKQRLLKLNVSNVKEDRIEEGIRKIMEEIKQVERLNFKFKKE

Sequences:

>Translated_456_residues
MYKYLHILNDIEKMIQNGAINEGQKLPSIRSLVTQYECNKATVIRALYELEKHHIIYSVPQSGYYVVKKSGSTIENNEII
DFASSAPDPDVFPYLDFQHCINKAIDTYKNDLFVYGTPKGLPSLIPVIQKQLANYQVFTKEDNIFITSGVQQALAILTSI
PFPNENETILVEQPTYHLYIEYLEINKVPVIGIKRTNEGIDLKELERIFRTGKIKFFYTIPRYHHPLGTSYSKDEKEKIV
LLAKKYNVFIVEDDYLADLETDSKADPLYSLDHGNHVIYLKSYSKIIFPGLRVGVAVIPPIISSAFHTYKKVLDIDSPMI
SQAALEIYIKSGMFERHKNKIQSSYNNRSKKLAEVLERMYSENPLLFTHKKQNTIGIHTCLEVHKTSISGMLIQRLSGMQ
ISIDTIDKNYVRGFPKQRLLKLNVSNVKEDRIEEGIRKIMEEIKQVERLNFKFKKE
>Mature_456_residues
MYKYLHILNDIEKMIQNGAINEGQKLPSIRSLVTQYECNKATVIRALYELEKHHIIYSVPQSGYYVVKKSGSTIENNEII
DFASSAPDPDVFPYLDFQHCINKAIDTYKNDLFVYGTPKGLPSLIPVIQKQLANYQVFTKEDNIFITSGVQQALAILTSI
PFPNENETILVEQPTYHLYIEYLEINKVPVIGIKRTNEGIDLKELERIFRTGKIKFFYTIPRYHHPLGTSYSKDEKEKIV
LLAKKYNVFIVEDDYLADLETDSKADPLYSLDHGNHVIYLKSYSKIIFPGLRVGVAVIPPIISSAFHTYKKVLDIDSPMI
SQAALEIYIKSGMFERHKNKIQSSYNNRSKKLAEVLERMYSENPLLFTHKKQNTIGIHTCLEVHKTSISGMLIQRLSGMQ
ISIDTIDKNYVRGFPKQRLLKLNVSNVKEDRIEEGIRKIMEEIKQVERLNFKFKKE

Specific function: Unknown

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=253, Percent_Identity=28.4584980237154, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI33469970, Length=253, Percent_Identity=28.4584980237154, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787710, Length=485, Percent_Identity=24.9484536082474, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790797, Length=401, Percent_Identity=23.9401496259352, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321236, Length=211, Percent_Identity=27.4881516587678, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356535, Length=407, Percent_Identity=23.8329238329238, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 52627; Mature: 52627

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKYLHILNDIEKMIQNGAINEGQKLPSIRSLVTQYECNKATVIRALYELEKHHIIYSVP
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECC
QSGYYVVKKSGSTIENNEIIDFASSAPDPDVFPYLDFQHCINKAIDTYKNDLFVYGTPKG
CCCEEEEECCCCEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
LPSLIPVIQKQLANYQVFTKEDNIFITSGVQQALAILTSIPFPNENETILVEQPTYHLYI
CHHHHHHHHHHHCCEEEEEECCCEEEECCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEE
EYLEINKVPVIGIKRTNEGIDLKELERIFRTGKIKFFYTIPRYHHPLGTSYSKDEKEKIV
EEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
LLAKKYNVFIVEDDYLADLETDSKADPLYSLDHGNHVIYLKSYSKIIFPGLRVGVAVIPP
EEEEECEEEEEECCCEECCCCCCCCCCCEEECCCCEEEEEECCCCHHCCCHHHHHHHHHH
IISSAFHTYKKVLDIDSPMISQAALEIYIKSGMFERHKNKIQSSYNNRSKKLAEVLERMY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SENPLLFTHKKQNTIGIHTCLEVHKTSISGMLIQRLSGMQISIDTIDKNYVRGFPKQRLL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCHHHEE
KLNVSNVKEDRIEEGIRKIMEEIKQVERLNFKFKKE
EEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure
MYKYLHILNDIEKMIQNGAINEGQKLPSIRSLVTQYECNKATVIRALYELEKHHIIYSVP
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECC
QSGYYVVKKSGSTIENNEIIDFASSAPDPDVFPYLDFQHCINKAIDTYKNDLFVYGTPKG
CCCEEEEECCCCEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
LPSLIPVIQKQLANYQVFTKEDNIFITSGVQQALAILTSIPFPNENETILVEQPTYHLYI
CHHHHHHHHHHHCCEEEEEECCCEEEECCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEE
EYLEINKVPVIGIKRTNEGIDLKELERIFRTGKIKFFYTIPRYHHPLGTSYSKDEKEKIV
EEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
LLAKKYNVFIVEDDYLADLETDSKADPLYSLDHGNHVIYLKSYSKIIFPGLRVGVAVIPP
EEEEECEEEEEECCCEECCCCCCCCCCCEEECCCCEEEEEECCCCHHCCCHHHHHHHHHH
IISSAFHTYKKVLDIDSPMISQAALEIYIKSGMFERHKNKIQSSYNNRSKKLAEVLERMY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SENPLLFTHKKQNTIGIHTCLEVHKTSISGMLIQRLSGMQISIDTIDKNYVRGFPKQRLL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCHHHEE
KLNVSNVKEDRIEEGIRKIMEEIKQVERLNFKFKKE
EEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8355609; 8969502; 9384377 [H]