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The map label for this gene is mutX [H]

Identifier: 52142809

GI number: 52142809

Start: 2568471

End: 2568989

Strand: Direct

Name: mutX [H]

Synonym: BCZK2431

Alternate gene names: 52142809

Gene position: 2568471-2568989 (Clockwise)

Preceding gene: 52142810

Following gene: 52142808

Centisome position: 48.45

GC content: 30.25

Gene sequence:

>519_bases
ATGTACAAGCACACTTTATGTTTTATAAAAAGAAATGAAGAAATACTCATGATAAATAGAGAATATGACCCTGTAAAAGG
GTTATGGAATGGTGTAGGAGGAAAGATAGAAAAGGGAGAAACACCTTTAGAAAATGCAATTCGTGAAATAAAAGAAGAGA
CTAATATAAAAGTTACGCATGATCAAATCCAATTTAAAGGCATTATTAAATGGGAGGATTCTTCATATTCTGGCGGAATG
TATGTTTATCTAGTAGAGTTACTTCATGAATTTACATATCACACTCCAAAAAAAGTCTCAGAAGGAATTCTAGATTGGAA
AGAAATCACTTGGATTCTAAGTGGCTATAATTACGGCGTAGGAGAGATGATACCTAAATTTTTAGTTGAAGTACTCTACA
ATGAATTAATATTAGAGCACAATTTTGTTTTATCTAATCATAAATTAATAGATTATAGGAATAAGGAATTGGTGCAGGAC
AGGTTACTTACTTCTTTATATAATACTATTCGCTTATAA

Upstream 100 bases:

>100_bases
TCTATGAGACCGATATTAATTGAAGCAGGGACACAATCTGCAGCAATCCATCTTATATCTCCAGTAAGAGCTTATTAAAA
ACGGAGGAAGGAAATACATT

Downstream 100 bases:

>100_bases
ATAACAAACTAAGAGAAAATAAAAATTTTAGATAGGAGATTCGATATGTGGAAAACAAATATTATCAAAACTCCAAGAGG
AAAGTTTGAATATTTTCTAA

Product: MutT/Nudix family protein

Products: dAMP; pyrophosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MYKHTLCFIKRNEEILMINREYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEITWILSGYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLIDYRNKELVQD
RLLTSLYNTIRL

Sequences:

>Translated_172_residues
MYKHTLCFIKRNEEILMINREYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEITWILSGYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLIDYRNKELVQD
RLLTSLYNTIRL
>Mature_172_residues
MYKHTLCFIKRNEEILMINREYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEITWILSGYNYGVGEMIPKFLVEVLYNELILEHNFVLSNHKLIDYRNKELVQD
RLLTSLYNTIRL

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20329; Mature: 20329

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHTLCFIKRNEEILMINREYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYVYLVELLHEFTYHTPKKVSEGILDWKEITWILSGYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCH
GEMIPKFLVEVLYNELILEHNFVLSNHKLIDYRNKELVQDRLLTSLYNTIRL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKHTLCFIKRNEEILMINREYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYVYLVELLHEFTYHTPKKVSEGILDWKEITWILSGYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCH
GEMIPKFLVEVLYNELILEHNFVLSNHKLIDYRNKELVQDRLLTSLYNTIRL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]