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The map label for this gene is lysP [H]

Identifier: 52142451

GI number: 52142451

Start: 2910121

End: 2911587

Strand: Direct

Name: lysP [H]

Synonym: BCZK2794

Alternate gene names: 52142451

Gene position: 2910121-2911587 (Clockwise)

Preceding gene: 52142448

Following gene: 52142446

Centisome position: 54.9

GC content: 39.47

Gene sequence:

>1467_bases
ATGAATAGCGCAACGAATCAAGCTACCTCTAAAACAGAAGCTACAAAAGGAAAAGGTGAATTAAGACGCGGTCTAAAATC
AAGGCACCTTACGATGATTTCTCTCGGCGGTACAATTGGTACCGGACTATTTCTTGCCAGCGGTGGTGTCATCCATTCAG
CTGGACCTGGCGGTGCATTAATTGCATACGCCGCAATTGGAATTATGGTTTACTTTTTAATGACAAGCTTAGCCGAACTC
GCAGCTTACATGCCTGTTACTGGATCTTTTAGCACGTACGCAACAAAATTTGTTGATCCATCACTTGGCTTTGCACTTGG
ATGGAACTATTGGTATAACTGGGCAATTACTATCGCTGCTGAACTAGCGGCTGTAACATTAATTATGAAATTTTGGTTTC
CAGATACTCCTTCCCTCATTTGGAGCGGATTATGTTTAGCTATTATTTTCCTTTTAAACTACTTATCTGTTAAAGGATTT
GGTGAATCTGAATATTGGTTCGCACTTATTAAAGTAGCTACAATTATTATCTTTTTAATTGTCGGGTTTATGATGATTTT
CGGAATTATGGGCGGCGAAACTGTTGGATTTAAAAACTTCACCGTTGCAGATGCACCATTTAACGGCGGCATCATGGCAA
TTATCGGTGTATTTATGGCAGCTGGTTTCTCATTCCAAGGTACTGAATTATTAGGTGTAGCTGCTGGTGAAACATCTGAT
CCAGAGCGTAATATTCCGAAAGCAATTCGTTCGATCTTTTGGCGTATTCTTTTATTCTATATCCTTGCGATTCTCGTTAT
CGGTTTATTAATTCCTTATACAACTGAAAGTCTTGCCGCAAGTGATGTAACAGTAAGTCCATTTACACTTATTTTTGAAA
AAGCGGGCGTTGCCTTTGCTGCTTCTGTTATGAACGCTGTTATTTTAACTGCTGTACTATCTGCTGGTAACTCTGGTATG
TATGCATCAACTCGTATGCTTTGGGACTTAGCTCGCCAAGGGAAAGCACCGAAGTTTCTTGGTAAATTAGATAGCCGCGG
CGTACCCGTTAACGCATTAATCGTAACATCGATTGTCGGTAGTATCGCTTTCATTGCTTCTTTATTCGGTGACGGTGTTG
TATACATTTGGTTATTAAATGCATCAGGAATGTCTGGCTTTATCGCATGGGTTGGAATCGCAATTAGTCATTACCGTTTC
CGTAAAGCATATATCGCACAAGGAAAAGATTTAAATGACTTACCTTATAGAGCAAAATGGTTCCCATTCGGACCAATCTT
CGCTTTTGCACTTTGTGTCATCGTAATTTTAGGTCAAAACTACGGCGCATTTATGGGCGAATCAATTGATTGGAACGGTG
TACTCGTTTCTTACATCGGTTTACCACTCTTCTTAGTACTATGGTTAGGATATAAATTTACGAAAAAAACAAAAGTCATT
CCACTTGATAAATGTGAACTGAAATAA

Upstream 100 bases:

>100_bases
GGGGTGGTTATTTGTGAAACGTTCCGCCAAATTCCTTTGGCGGTTTTTTGTATTTTTCTCCCCCGCTCCTTCCTATCTTA
CAAGAAAAGGAGTGTTGAAC

Downstream 100 bases:

>100_bases
AAGGAGACGAGCAAACAAATTTGTTTGCTCGTTTTTTATTGCAAACCTCTTTGCTTCCCTATTGCCCCTGTTTTTGCAAT
AATAAAGGAAATATAAATAA

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNSATNQATSKTEATKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Sequences:

>Translated_488_residues
MNSATNQATSKTEATKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK
>Mature_488_residues
MNSATNQATSKTEATKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=62.7858627858628, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=470, Percent_Identity=38.936170212766, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=36.3829787234043, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=36.6589327146172, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87081915, Length=427, Percent_Identity=34.4262295081967, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1790653, Length=349, Percent_Identity=37.8223495702006, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=394, Percent_Identity=34.7715736040609, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=36.4102564102564, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87081869, Length=422, Percent_Identity=25.1184834123223, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082023, Length=414, Percent_Identity=25.8454106280193, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082250, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=360, Percent_Identity=23.6111111111111, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=484, Percent_Identity=38.4297520661157, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=491, Percent_Identity=34.6232179226069, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6322892, Length=498, Percent_Identity=37.3493975903614, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6324990, Length=497, Percent_Identity=33.1991951710262, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=494, Percent_Identity=35.2226720647773, Blast_Score=292, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6324924, Length=493, Percent_Identity=34.2799188640974, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6320717, Length=495, Percent_Identity=32.1212121212121, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=511, Percent_Identity=31.1154598825832, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=443, Percent_Identity=33.8600451467269, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319542, Length=505, Percent_Identity=30.8910891089109, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320251, Length=501, Percent_Identity=30.5389221556886, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6322967, Length=466, Percent_Identity=31.5450643776824, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319824, Length=509, Percent_Identity=29.0766208251473, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=487, Percent_Identity=31.211498973306, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=32.0512820512821, Blast_Score=236, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6319608, Length=474, Percent_Identity=27.6371308016878, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324981, Length=487, Percent_Identity=30.3901437371663, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=561, Percent_Identity=27.2727272727273, Blast_Score=173, Evalue=6e-44,
Organism=Drosophila melanogaster, GI281366235, Length=390, Percent_Identity=23.3333333333333, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007820, Length=390, Percent_Identity=23.3333333333333, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007818, Length=391, Percent_Identity=23.2736572890026, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI85725152, Length=391, Percent_Identity=23.2736572890026, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52691; Mature: 52691

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSATNQATSKTEATKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCHHHHCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC
>Mature Secondary Structure
MNSATNQATSKTEATKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCHHHHCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]