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The map label for this gene is gabP [H]

Identifier: 52141766

GI number: 52141766

Start: 3606911

End: 3608305

Strand: Reverse

Name: gabP [H]

Synonym: BCZK3482

Alternate gene names: 52141766

Gene position: 3608305-3606911 (Counterclockwise)

Preceding gene: 52141762

Following gene: 52141765

Centisome position: 68.07

GC content: 36.99

Gene sequence:

>1395_bases
TTGGATAAAAATCTTAAGAAAGACCTCAAAATACGCCACATTACAATGATCTCAATTGGCGGCGTAATAGGAGCTGGTTT
GTTTGTTGGAAGTGGGGCAGTTGTGCATTCAGCAGGACCAGGTTCTATCGTTTCATATGCATTAGCAGGACTTCTAGTCG
TTTTCGTTATGAGAATGCTTGGGGAAATGGCAGCTATTAACCCGACAAGTGGGTCATTTGCAACATATGCAAGAGAAGCA
ATTGGTCCGTGGGCCGGTTATACAATTGGGTGGCTATATTGGTTTTTCTGGGTAATTGTTATTGCGATAGAAGCCACAGC
GGGTGCTGGTATTATTCAGTACTGGATTCCAGAAATCCCACTTTGGTTATTAAGCTTAATATTAACGATTTTATTAACAT
TGACGAATGTTTTTTCAGTGAAATCATTTGGAGAGTTTGAATATTGGTTTTCTTTTATTAAAGTAATAAGTATTGTTTTG
TTCCTTTGTCTTGGACTAGCTGTTATTTTAGGATTTGTACCAGGAACGGAAGCACCTGGCACTTCGAACTTAGTGGGGCA
AGGAGGATTTATGCCAAATGGTATAAGTTCGGTGCTACTTGGAATTACTGTCGTTATATTTTCATTTATGGGATCAGAGA
TTGTAGCGGTAGCAGCTGGTGAGTCTGCAGAACCTGTAAAAGCAGTAAAAACAGCAACAAATAGTGTAATTTGGCGTATT
CTCGTATTTTTCATTGGATCTATCGCTGTAGTTGTTACACTTCTTCCGTGGAATTCAGCAAACATACTAAAAAGTCCGTT
TGTAGCGGTGCTAGAACATATAGGGATACCAGCGGCAGCGCAAATTATGAATTTTATCGTTTTAACAGCTGTACTTTCTT
GTTTAAATTCTGGTTTATATACGAACTCAAGAATGCTTTTTTCGATGGCAGAAAGAGGAGATGCTCCAAAGGCGTTTTTG
AAATTGAACAGTAGTGGTGTTCCAGTTCGGGCTGTTTTATTCGGAACGTTCTTCGCTTATATTGGAGTTGTTTTTAGTTA
CATATCTCCAGATAAAGTCTTTTTATTTTTAGTGAATGCCTCTGGCGGGATTGCGTTACTCGTTTATCTCGTTATAGCTA
TTTCGCATTTAAAGATTCGTAAAAAAATGGGAAGAGTAGAACAACAAAATTTGAAAGTGAAAATGTGGTTTTTCCCGTAT
GTGACGTATGTTACAATTGCAGCTATTATAGCAGTTTTAATTGCGATGCTTGCCATTGAATCTTTACGTTCACAAGCACT
TTTGACAATGCTTGTTACTGTTCTTATAATCATTTCTTATTTTATTTTTAATAGAAATAAAAATAGTACAGTGTTGAATA
CTAAAAGTAAGAATGAGGAATCTGTCCGATTTTAA

Upstream 100 bases:

>100_bases
CCTAACTTCTTTGTTTCCGCTGAATTTGGAGGTGGGGGTCTTACTGCCCGTTAATGCGGGGCAAATTTCAAAATTACGTT
TGGAAGGGGATGTATAAGAG

Downstream 100 bases:

>100_bases
TTTCTTGTTTTCTAAGAAATGCTACATCCAATCATTGGTAGAAAAGAGTAATTATTATTGTCATAGTGAATATAAACTTT
TTTCTTGACTTTTTATACGA

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTVLNTKSKNEESVRF

Sequences:

>Translated_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTVLNTKSKNEESVRF
>Mature_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPY
VTYVTIAAIIAVLIAMLAIESLRSQALLTMLVTVLIIISYFIFNRNKNSTVLNTKSKNEESVRF

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=370, Percent_Identity=25.4054054054054, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI258614003, Length=370, Percent_Identity=25.4054054054054, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI258645169, Length=369, Percent_Identity=25.2032520325203, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4507047, Length=429, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110347453, Length=352, Percent_Identity=23.8636363636364, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=50.1118568232662, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1786302, Length=418, Percent_Identity=38.5167464114833, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI48994972, Length=450, Percent_Identity=38.2222222222222, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=40.1459854014599, Blast_Score=304, Evalue=9e-84,
Organism=Escherichia coli, GI87081708, Length=455, Percent_Identity=35.6043956043956, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=34.6067415730337, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1790653, Length=431, Percent_Identity=36.6589327146172, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=35.2297592997812, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI87081915, Length=411, Percent_Identity=37.2262773722628, Blast_Score=265, Evalue=7e-72,
Organism=Escherichia coli, GI2367353, Length=460, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87081869, Length=322, Percent_Identity=24.223602484472, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=374, Percent_Identity=23.7967914438503, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=340, Percent_Identity=25, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=426, Percent_Identity=34.2723004694836, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=425, Percent_Identity=33.8823529411765, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=469, Percent_Identity=29.8507462686567, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=34.020618556701, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=427, Percent_Identity=33.0210772833724, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=28.1779661016949, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=33.756345177665, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=408, Percent_Identity=32.5980392156863, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=30.3703703703704, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=440, Percent_Identity=29.3181818181818, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=420, Percent_Identity=30.4761904761905, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=28.8888888888889, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=394, Percent_Identity=26.6497461928934, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=409, Percent_Identity=28.1173594132029, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=28.7128712871287, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=436, Percent_Identity=25.2293577981651, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=28.3208020050125, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=22.9508196721311, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221512776, Length=334, Percent_Identity=23.3532934131737, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=334, Percent_Identity=23.3532934131737, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667468, Length=419, Percent_Identity=23.3890214797136, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24668806, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356285, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24668802, Length=405, Percent_Identity=23.2098765432099, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50286; Mature: 50286

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDAPKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPYVTYVTIAAIIAVLIAMLAIE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SLRSQALLTMLVTVLIIISYFIFNRNKNSTVLNTKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDAPKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAISHLKIRKKMGRVEQQNLKVKMWFFPYVTYVTIAAIIAVLIAMLAIE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SLRSQALLTMLVTVLIIISYFIFNRNKNSTVLNTKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]