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The map label for this gene is dxr

Identifier: 52141667

GI number: 52141667

Start: 3717452

End: 3718594

Strand: Reverse

Name: dxr

Synonym: BCZK3580

Alternate gene names: 52141667

Gene position: 3718594-3717452 (Counterclockwise)

Preceding gene: 52141666

Following gene: 52141668

Centisome position: 70.15

GC content: 38.76

Gene sequence:

>1143_bases
ATGAAAAACATTAGTTTATTAGGTGCAAGCGGATCAATTGGTACACAAACTTTAGATGTATTACGCTCGCACCCAGACCA
ATTCCGTCTCGTTGCTTTTTCTGTAGGGAAAAATATTGACTACGCAGTAAAGGTCATTCAAGAATTTTCTCCACAAATTG
TCTCTGTGCAAAGAGAGGAAGATGTTTTAAAATTACAAGCTGTTTCTGGTAATACAAAAATTGTATATGGTAGTGAAGGG
CTTTTAGAAGTAGCATTACATCCAGATGCGGAGATTGTAGTAAACGCTGTTGTAGGTAGCGTAGGGTTGTTACCAACACT
TCGTGCAATTGAGGCGAAAAAAACAATTGGAATTGCAAACAAAGAAACGTTAGTAACTGCAGGGCATCTTGTAATGGAAG
CAGCGCGAAAACATAATGTTTCGTTACTTCCAGTAGACAGTGAACATTCAGCTATTTTTCAATGCTTGAATGGTGAAAAT
GAAAAAAGAATTTCTCGACTAATTATAACGGCTTCTGGTGGAAGTTTCCGTGATAAAACGAGAGATGAATTGCATCATGT
GACCGTAGAAGATGCGCTTCGACATCCAAACTGGTCAATGGGTTCGAAAATTACAATTGATTCTGCTACAATGATGAATA
AGGGGCTAGAAGTAATTGAAGCACATTGGCTTTTTGGTATCCCTTATGAGCAAATCGATGTTGTTTTACATAAAGAAAGT
ATTATTCATTCTATGGTTGAATTTGAAGATCGTAGTGTGATGGCACAGCTTGGCTCACCTGATATGCGAGTACCAATTCA
ATACGCGCTTACATATCCTGATCGATTACCTCTTTCAGACACAAAGCAGTTAAACTTATGGGAAATAGGAACGTTGCATT
TTGAGAAGATGAACCAAGAGCGTTTCCGTTGCCTACGTTTTGCGTATGAAGCTGGAAAAGCAGGTGGAAGTATGCCAGCT
GTAATGAATGCAGCGAATGAAGTAGCTGTTGAAGCTTTTTTACAAAAGAGAATTGGTTTCTTAACAGTGGAAGACCTCAT
TGAAAAAGCAATGAACCATCACAATGTCATTGCACGTCCGAGCTTAGAGGAAATTCTGGAAATTGATGCAGCCACAAGAC
GGTTTGTGATGGAACAAATTTAG

Upstream 100 bases:

>100_bases
ATGGTGGTATATTAGATCGAACAGATAGTTGGTTATTCGTTTTACCAATTCTCTACTTCTTATTACAATATAATTAATGA
ATGAACGAGGGGTTGGAATC

Downstream 100 bases:

>100_bases
CAAAGGTGGTATGGAATTGAATACAGCGATTGCCTTTATATTAATTTTCGGTGCACTCGTATTTTTCCATGAGCTAGGGC
ATCTATATTTCGCAAAAAGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 2; 1-deoxyxylulose-5-phosphate reductoisomerase 2; 2-C-methyl-D-erythritol 4-phosphate synthase 2

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKIVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Sequences:

>Translated_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKIVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI
>Mature_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKIVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=41.3705583756345, Blast_Score=301, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR2_BACAN (Q81WL4)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846202.1
- RefSeq:   YP_020598.1
- RefSeq:   YP_029923.1
- ProteinModelPortal:   Q81WL4
- SMR:   Q81WL4
- EnsemblBacteria:   EBBACT00000010342
- EnsemblBacteria:   EBBACT00000016898
- EnsemblBacteria:   EBBACT00000021953
- GeneID:   1086817
- GeneID:   2819523
- GeneID:   2849846
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3959
- KEGG:   bar:GBAA_3959
- KEGG:   bat:BAS3672
- TIGR:   BA_3959
- TIGR:   GBAA_3959
- GeneTree:   EBGT00050000001768
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   BANT260799:BAS3672-MONOMER
- BioCyc:   BANT261594:GBAA3959-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42239; Mature: 42239

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: BINDING 121-121 BINDING 148-148 BINDING 172-172 BINDING 195-195 BINDING 217-217

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKIVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHHEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCHH
RFRCLRFAYEAGKAGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKIVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHHEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCHH
RFRCLRFAYEAGKAGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629