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The map label for this gene is uppS [H]

Identifier: 52141665

GI number: 52141665

Start: 3719427

End: 3720203

Strand: Reverse

Name: uppS [H]

Synonym: BCZK3582

Alternate gene names: 52141665

Gene position: 3720203-3719427 (Counterclockwise)

Preceding gene: 52141664

Following gene: 52141666

Centisome position: 70.18

GC content: 37.97

Gene sequence:

>777_bases
ATGATGTTTAAAAACTTTCCTTTTTTTAAAGGTAAAAAGGACACATCGTTTGATCATCTCGTTGAAGAAGTAAAAAAAGG
ATATATCCCAGAACATATTGCGATCATTATGGATGGTAATGGAAGATGGGCGAAGAGGAGAGCAATGCCTCGTATTGCGG
GACATCATGAAGGTATGCAAGTTGTAAAGAAAATTACAAAATTTGCAAGTAAACTTAATGTGAAAGTGTTAACTCTCTAT
GCTTTTTCGACTGAGAACTGGAAAAGACCGAAAAAGGAAGTTGATTATTTAATGAAGCTTCCAGAAGAATTTTTAGGTAC
ATTTTTACCAGAATTGATTGAAGAAAACGTACAAGTCCGAGTAATAGGGCAACAAGATCGTCTTCCTACGCATACACGCA
GAGCGATGGAGAAGGCCATGGAAGAAACGAAAGAGAATACGGGATTAATTCTTAATTTCGCGTTAAACTATGGAAGTCGA
GATGAAATCGTTTCTGCTGTGCAACATATGATGAAAGATAGTGAGGAAGGAAAGGTTCGTGTTGAAGATGTAAGTGAAGA
AATGCTTTCTTCCTACTTAATGACGAGTTCTTTACCTGACCCAGAGTTGTTAATCCGTACGAGCGGAGAGCTACGTATTA
GTAATTTCATGTTATGGCAAATTGCATATTCGGAATTTTGGTTTACAGATGTGTATTGGCCAGATTTTACCGAGGAACAT
TTGCTAAATGCGATTACAGACTTTCAACATAGAGGGCGCAGATTCGGAGGCGTGTAG

Upstream 100 bases:

>100_bases
ATCATGGAAGTGTAATAGCGATACCTTCGCAAATATGACCCTCTTCTTAAGGGGGTCTTTTTACACTTTTAGGCATACGT
CTGCTTGCTGGAGGGTATGA

Downstream 100 bases:

>100_bases
AAAGAGAGGGTTTGGTAGTGAAACAGAGAATTATTACTGGAGTGGTTGCTGCCGCGCTATTCATTCCCATCGTAATTTAC
GGTGGCGTGCCTTTTACGGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV

Sequences:

>Translated_258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV
>Mature_258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=39.3013100436681, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=39.3013100436681, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=44.9339207048458, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=35.3448275862069, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=32.15859030837, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=31.924882629108, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=38.4955752212389, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30161; Mature: 30161

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHH
VVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEE
VEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHHEEECCCCCCCHHH
LLNAITDFQHRGRRFGGV
HHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHH
VVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEE
VEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHHEEECCCCCCCHHH
LLNAITDFQHRGRRFGGV
HHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]