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The map label for this gene is pyrH

Identifier: 52141663

GI number: 52141663

Start: 3720849

End: 3721571

Strand: Reverse

Name: pyrH

Synonym: BCZK3584

Alternate gene names: 52141663

Gene position: 3721571-3720849 (Counterclockwise)

Preceding gene: 52141662

Following gene: 52141664

Centisome position: 70.21

GC content: 39.28

Gene sequence:

>723_bases
ATGAGTAAACCGAAATATAATCGTGTCGTTTTAAAGCTGAGTGGAGAAGCTTTAGCTGGCGAGCAAGGATTTGGAATTAA
CCCAGCTGTTATTAAATCAGTTGCGGAACAAGTGAAAGAAATTGCAGAACTTGATGTAGAGGTTGCTGTTGTTGTTGGTG
GCGGTAACATTTGGCGTGGAAAAATTGGAAGTGAGATGGGCATGGATCGTGCAGGAGCAGATTACATGGGCATGTTAGCG
ACAGTTATGAATTCATTAGCTCTTCAAGATAGCTTGGAGAATATCGGAATTCAAACTCGCGTACAAACTTCAATTGAGAT
GCGTCAAGTGGCAGAGCCTTACATTCGTCGTAAAGCAGTTCGTCACTTAGAGAAGAAACGTGTTGTTATCTTTGCAGCAG
GTACAGGTAATCCATACTTCTCTACAGATACAACAGCAGCATTACGTGCAGCAGAAATTGAAGCAGACGTAATTTTAATG
GCGAAAAACAATGTAGATGGCGTATATAATGCGGATCCATCTATTGACCCAACAGCTACGAAATACGAAACGCTTACTTA
CTTAGATGTATTAAAAGAAGGTTTAGGTGTAATGGATTCTACAGCTTCTTCTCTATGTATGGATAATGATATTCCATTAA
TTGTATTCTCAGTTATGGAAAAAGGTAATATTAAACGTGCCGTTTTAGGTGAAAATATCGGAACAGTTGTAAGGGGGAAA
TAA

Upstream 100 bases:

>100_bases
AGAAGTAATGAACCAAGTAAAAGGTAGTAACTAATACAGATTAGGGAACACATTGTGTTCCCTTTTTTAAAATAAAGATG
TAAGCAATTGGAGGTTCATT

Downstream 100 bases:

>100_bases
ATATGGGACAACAAGTATTAAAGTCTTCAAATGAAAAAATGGAAAAAGCAGTTGCTGCTTATTCTCGTGAATTAGCAACA
GTTCGTGCTGGCCGTGCAAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSKPKYNRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLA
TVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK

Sequences:

>Translated_240_residues
MSKPKYNRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLA
TVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
>Mature_239_residues
SKPKYNRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLAT
VMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMA
KNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=48.3050847457627, Blast_Score=234, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_BACAN (Q81WL0)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846206.1
- RefSeq:   YP_020602.2
- RefSeq:   YP_029927.1
- ProteinModelPortal:   Q81WL0
- SMR:   Q81WL0
- EnsemblBacteria:   EBBACT00000009368
- EnsemblBacteria:   EBBACT00000014903
- EnsemblBacteria:   EBBACT00000024399
- GeneID:   1086816
- GeneID:   2819541
- GeneID:   2850619
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3963
- KEGG:   bar:GBAA_3963
- KEGG:   bat:BAS3676
- TIGR:   BA_3963
- TIGR:   GBAA_3963
- GeneTree:   EBGT00050000001796
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   BANT260799:BAS3676-MONOMER
- BioCyc:   BANT261594:GBAA3963-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25870; Mature: 25739

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPKYNRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRG
CCCCCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEC
KIGSEMGMDRAGADYMGMLATVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPSIDPTAT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEEEECCCCCEECCCCCCCCCCC
KYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
HHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCEEEEEECCCCCCEEHHHCCCCCEEECCC
>Mature Secondary Structure 
SKPKYNRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRG
CCCCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEC
KIGSEMGMDRAGADYMGMLATVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPSIDPTAT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEEEECCCCCEECCCCCCCCCCC
KYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
HHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCEEEEEECCCCCCEEHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629