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The map label for this gene is glmU [H]

Identifier: 52141232

GI number: 52141232

Start: 4124835

End: 4127189

Strand: Reverse

Name: glmU [H]

Synonym: BCZK4017

Alternate gene names: 52141232

Gene position: 4127189-4124835 (Counterclockwise)

Preceding gene: 52141231

Following gene: 52141234

Centisome position: 77.86

GC content: 36.01

Gene sequence:

>2355_bases
ATGAAGGGGGTTATTTTAGCTGGAGGAAAAGGACGACGCCTTAGACCATTAACATGTAATACTCCAAAGCCGATGTTGCC
ATTATTAGAAAAGCCAGTTTTGGAATACAATATTGAATTATTGCGTCAGCATGGTATACGTGAGATTGCAATTACTGTTC
AGTATATGAGTACGGCCATTAAGCAATATTTTGGTGACGGTAGCAAATGGGGCGTTAACTTGTACTACTTTGAAGACTCT
CCACCGCTTGGAACTGCAGGGAGTATTAAACAAGCGGAAAAATTTTTGGATGAAACGTTTGTTGTCATAAGTGGGGATGC
GTTAACTGATTTTCAATTATCAAAAGGAATTACGTTTCATGAACAACAGAAAAGAATGGTAACTATGTTTGTAAAGGAAG
TAGAAAATCCACTCTCATTCGGTCTAGTTGTAATGAACAAAGAACAAGAGGTTACACGATATATAGAAAAACCGAGTTGG
AATGAAGTAGTCTCTAATATTGTGAATACAGGTATATATATTATGGAGCCAGAAATTTTTTCTTACATACCGCCCCGAGA
ATTTTTTGATTTCAGTCAAGATGTGTTTCCATTATTGGCAAATAAAAACGCATTATTTGCATATTTATCAGAAGGTTATT
GGTTAGATATCGGTACATTTGATCAATATCGACAAGCCCAATTTGATTTGTTAACAAAAAAATTGCAAGTACCTATTCCT
TATACTGAAGTATTGCCGATGGTATGGATGGGGGAAGGTGTGACGATTGGAAAAGGCACAAAAATTCACGGCCCTTCTTT
TATTGGAGAGGGAGCAAAAATTGGTGCCGGGGCTGTAATTGAGCCGTACTCTATTATCGGGAAAAATAGTATTGTTTCGA
GTTATTCTCATCTTCAAAAAAGTATTGTTTTTGCAAATGTGCACATTGGACAATATTGCGAGTTATTAGAAACGACAATA
GGAGAGCATACAATGGTGGAAGATGACGTTACATTGTTTCAAAAAAGCATTGTAGCAGATCATTGTCATATAGGGAAAAG
TACGGTAATTAAGCAAAAGGGAAAACTATGGCCATATAAGGCGATTGATAGCTATTCGGTAGTAGGATCGGCTGGTGTTC
AAGAAAGTGAAAAGAGCGCCGGATGGCTGCAAAAAAGTCGCATTGTAGGAAGAGGGAACGTTGAAATCACCCCTCAATTT
ATAGTAAAGGTAGCGATGGCGTACGGATCCCTTTTTACCAAAGGGGAAAGTATATTAATCGGGAGCCAAGAACATATAGA
AACGACTTCTTATAAAAATCTTTTTCTTCATGCGATTCATGGTATTGGGATTCATACGATGGAATGCAAAGAAATGAACG
AATCGCTTTTTCAGTATAGCATTCAAGATTTACAATGTGCAGGTGGAGTTTTCATTCAAGTGGAAAATGAAAAAGAGGTT
ATTATAAAGTTGTATGGTCAGGATGGGGCACAATTAACGTATAAGCAGCAAAAAGCGATCGAACAAGTATATATGTCTGA
GTCTTTTTATTACGTATGTGAGAAAGAAATGGGGCGAAATAAGCTGGTCCATGTTTCTTTACATGATTATATAGAGGCTG
TATTAGAGCGCATTGATATTGAGAAAATACAAAAACAGAAGTTCCACCTTCTTATTAATAAGAGAAATGATATGTTACAA
CATTTACTTATGCTTTTTTTGCAAAGGCTTGGATGCACAGTTACGTGGATTTATGCAGGTGAACAGAAGAATCATGTGAA
GGCCTTGATGAAATCAAGTAAAGCGAATATGGCACTCATGTTTTCAGAGCAAGGAAATTATTTTGAGTTATATGATAATC
ATAGTAACATTTACCAGGGGACAGATTTTGAAGAGGTAGATATTCCAGATTTATTACTTGAATCGGCAGGAAATATTTAC
CCAATGTCTTTGAAATTAGGAGAATGTTACCTTCTATTTTATACGCAGGATGAAAAAAAGTCGTTTCAAGCGAGATGGAA
GCGAGATATTCTATATCGAATTGGAAAATTATTTGAGCTAATAGCATTGCAGGGAAAAACATTTCTCAGCATAGTAGAGC
AATCACCTCCGCTCTATTTACTTTGTGATGAAGTTGTATGTTCATGGAATGAAAAAGGGAAAGTGATGAGGAAATTATTG
GCTGATATGGAAAGAAAGGAAGAAGGTATATTTGAAGGAGTACAGTTCAAATATACCGAAAAAGAGTGGTCTTATATCGT
TTCTGACACAAAACAACCGAAATTTTTAGTGTATTCACATGCTAGAAACCCAGTCATAGCAAGGGAAAACATGAAAAATC
TTATAGAAAAAATTAGACAATATCAAAAGGTGTAG

Upstream 100 bases:

>100_bases
TAATGAAATTTTTATTTTATACTGCTAGTTAATGATGGGTAGATAATATACATATCGTATATGAAGTTACTGAACATTAT
ATAAGTGGAGGCTGAAGTAT

Downstream 100 bases:

>100_bases
AATTTTTATTTTAAAAGTGGTATTATAGTATAGTCTGATTTAAGTTATTAGTACTGGAGGGAAATAAGAATGCGTGTGAA
TATTACTCTAGCATGTACAG

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPPREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANVHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKNHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQARWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV

Sequences:

>Translated_784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPPREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANVHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKNHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQARWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV
>Mature_784_residues
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAIKQYFGDGSKWGVNLYYFEDS
PPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFHEQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSW
NEVVSNIVNTGIYIMEPEIFSYIPPREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQKSIVFANVHIGQYCELLETTI
GEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYKAIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQF
IVKVAMAYGSLFTKGESILIGSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDIEKIQKQKFHLLINKRNDMLQ
HLLMLFLQRLGCTVTWIYAGEQKNHVKALMKSSKANMALMFSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIY
PMSLKLGECYLLFYTQDEKKSFQARWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQYQKV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=365, Percent_Identity=29.5890410958904, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI11761619, Length=385, Percent_Identity=27.7922077922078, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI31881779, Length=355, Percent_Identity=28.7323943661972, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI45447090, Length=355, Percent_Identity=28.7323943661972, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1788351, Length=227, Percent_Identity=31.2775330396476, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1790224, Length=235, Percent_Identity=31.9148936170213, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789837, Length=383, Percent_Identity=21.1488250652742, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=353, Percent_Identity=29.7450424929178, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17509979, Length=341, Percent_Identity=26.6862170087977, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17509981, Length=331, Percent_Identity=25.6797583081571, Blast_Score=89, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=374, Percent_Identity=27.807486631016, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21355443, Length=361, Percent_Identity=31.5789473684211, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24644084, Length=361, Percent_Identity=31.5789473684211, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24653912, Length=372, Percent_Identity=26.8817204301075, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 89716; Mature: 89716

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAI
CCCEEEECCCCCEECCEECCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHH
KQYFGDGSKWGVNLYYFEDSPPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFH
HHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCEECCHHHCCCCHH
EQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSWNEVVSNIVNTGIYIMEPEIF
HHHHHHHHHHHHHHCCCHHEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHH
SYIPPREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
HCCCCHHHHCCCCCHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQK
HHHHCCHHEECCCEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHHH
SIVFANVHIGQYCELLETTIGEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYK
HEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
AIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQFIVKVAMAYGSLFTKGESILI
CCCCEEECCCCCCCCCHHHHCHHHHHCEEECCCCEECHHHHHHHHHHHHHHHCCCCEEEE
GSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
CCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDI
EEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEHHHHHHHHHHHHCH
EKIQKQKFHLLINKRNDMLQHLLMLFLQRLGCTVTWIYAGEQKNHVKALMKSSKANMALM
HHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEE
FSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIYPMSLKLGECYLLFYTQDEKK
EECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCEEEEEEECCHHH
SFQARWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECHHHHCCCCCHHHHHHHH
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQ
HHHHHHHHHHHCCCEEEEECCHHHHEECCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
YQKV
HHCC
>Mature Secondary Structure
MKGVILAGGKGRRLRPLTCNTPKPMLPLLEKPVLEYNIELLRQHGIREIAITVQYMSTAI
CCCEEEECCCCCEECCEECCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHH
KQYFGDGSKWGVNLYYFEDSPPLGTAGSIKQAEKFLDETFVVISGDALTDFQLSKGITFH
HHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCEECCHHHCCCCHH
EQQKRMVTMFVKEVENPLSFGLVVMNKEQEVTRYIEKPSWNEVVSNIVNTGIYIMEPEIF
HHHHHHHHHHHHHHCCCHHEEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHH
SYIPPREFFDFSQDVFPLLANKNALFAYLSEGYWLDIGTFDQYRQAQFDLLTKKLQVPIP
HCCCCHHHHCCCCCHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
YTEVLPMVWMGEGVTIGKGTKIHGPSFIGEGAKIGAGAVIEPYSIIGKNSIVSSYSHLQK
HHHHCCHHEECCCEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHCCHHHHHHHHHHHH
SIVFANVHIGQYCELLETTIGEHTMVEDDVTLFQKSIVADHCHIGKSTVIKQKGKLWPYK
HEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
AIDSYSVVGSAGVQESEKSAGWLQKSRIVGRGNVEITPQFIVKVAMAYGSLFTKGESILI
CCCCEEECCCCCCCCCHHHHCHHHHHCEEECCCCEECHHHHHHHHHHHHHHHCCCCEEEE
GSQEHIETTSYKNLFLHAIHGIGIHTMECKEMNESLFQYSIQDLQCAGGVFIQVENEKEV
CCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IIKLYGQDGAQLTYKQQKAIEQVYMSESFYYVCEKEMGRNKLVHVSLHDYIEAVLERIDI
EEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEHHHHHHHHHHHHCH
EKIQKQKFHLLINKRNDMLQHLLMLFLQRLGCTVTWIYAGEQKNHVKALMKSSKANMALM
HHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEE
FSEQGNYFELYDNHSNIYQGTDFEEVDIPDLLLESAGNIYPMSLKLGECYLLFYTQDEKK
EECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEECCEEEEEEECCHHH
SFQARWKRDILYRIGKLFELIALQGKTFLSIVEQSPPLYLLCDEVVCSWNEKGKVMRKLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECHHHHCCCCCHHHHHHHH
ADMERKEEGIFEGVQFKYTEKEWSYIVSDTKQPKFLVYSHARNPVIARENMKNLIEKIRQ
HHHHHHHHHHHCCCEEEEECCHHHHEECCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
YQKV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]