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The map label for this gene is pbpA [H]

Identifier: 52141226

GI number: 52141226

Start: 4132320

End: 4134440

Strand: Reverse

Name: pbpA [H]

Synonym: BCZK4023

Alternate gene names: 52141226

Gene position: 4134440-4132320 (Counterclockwise)

Preceding gene: 52141225

Following gene: 52141227

Centisome position: 77.99

GC content: 36.73

Gene sequence:

>2121_bases
ATGAGCAAGAAGCAGAAACAACAAAAGAAAAAGACTCACGTTCCTTTTCGGTTAAACGTGCTGTTTTTCTGCGTGTTTTT
AATGTTCTCCGCGGTTATTGTAAGGCTTGGATATGTACAAATTGTTCGCGGTGAGGAATATAAAAATGAAGTGGAGAGGA
AAGAGAACTCGACGATTAGTAATCCTGTACCACGTGGGAAAATATTTGACCGTTATGGGCGAGCTGTAGTAGATAATGCA
GCTGTACGTACGATTACATTTACAAAAATGAAAGGATCAACTGCAGAGGCTCGCTTAGAAACAGCGAAAAAGCTAGCAGA
TTTGATTGAAGTACCGACAGATAAATTAACAGATCGCGATAAGAAAGATTATTGGCTTGCTATTCATAAAGAGGAAGCGA
AAGAAAAAATTACGAATAAAGATCGTCAAGAGTTTAAAGATAAAAAAATTGACGATAAAGAATTAGATGAGCGTCAACGA
AATCGCGTGACAGAAGAAGAAGTGAATCAATTATCCGCAAAAGATTTAGAAGTACTAGCGATTAAAAGCAAAATGGACGG
CGGATATGCGATGACGCCACAAGTTATTAAAAAGGATGCTACAGAACAAGAATATGCGATTATTAGTGAAAATCTAGCAA
CATTACCGGGTGTAGATACGAATGTTGATTGGGATCGAAAGTATATTTATGATGATTTATTCCGAAGTGTACTTGGCGGG
GTGTCAACGTCTGATGAAGGTTTACCTAGAGAAAGACTAGATTACTATCTTGTTCGTGATTATAATCGAAATGACCGCGT
AGGGAAAAGTTATCTTGAGCAGCAATATGAAGATAGTTTGCACGGTAATAAAGCGGAAGTGAGAAATGTTACAGATAAAA
ACGGTAATATTTTAGAAACGATTAATGTATCAAAAGGGCAAAGTGGTAATAATCTAAATTTAACAATTGATATGGAATTA
CAAAAGCGTGTAGAAGAAATTATCACGAAAAATTTATTGAGATATAAAGGTGGACAACCCTATTTAGATCGTGCATTCGT
TGTAATGATGAATCCAAAAAATGGTGAAGTTTTATCTATGGCAGGGAAACAGTTAGTGGAAGAAAATGGCGAAACGAAAG
TGCAAGATTTCGCATTAGGAACGATGACAAGCTCTTATCCGATGGGATCAACTGTAAAAGGTGCGACAGTACTTACAGGA
TATCAAACAAATGCAATTCAACCAGGTTCAGTTCAACTTGATGAACCAATCAGATTAAAGGGAACGCCACCAAAATCTTC
GTGGAAGACGATGGGATATATTAATGATTTAACAGCATTAAAAATGTCTTCTAACGTATATATGTTTAAAACAGCGATGA
ATATCGCAGGCGTTCCATATGTAAGAGGTGGTACGTTAGATATACCACAAAAAGCATTTGATACGATGCGTTATTATTTC
GGACAGTTTGGACTTGGCGTAAAAACAGGTATTGATTTACCAAATGAATCTGCGGGCCAAACAGGTAGAGGAAATCAGCC
AGGTTTCCTATTAGATTTATCAATTGGACAGTATGATACGTATACACCACTTCAATTAGCACAATATGTTTCAACAATTG
CAAATGGTGGATATCGTATGCAGCCGCAAGTTGTAAAGGAAATTCGTCAACCGTCAGCGAAACAAGACGAAGTTGGAAAA
GTTGTTCATTCAATGGAGCCGAAAGTACTAAATCGTATTGATATGCCTGAATCACAAATTAAACGTGTTCAGGAAGGATT
TAGACAAGTATTTAACGATTCTGGTGGTACAGCTGCAAAATACTTTGCAGGTGCACCATATAAAGCTGCTGGTAAAACAG
GTACAGCTCAAACTGTGTATGGCGGAGATAAAGAGATTGGTAAAAAGGCAAACGGTGAGCGTAAAGAAACATATAATTTA
ACATTAGTAGGTTATGCGCCACTTGAAGACCCTGAAGTAGCATTTTCTGTTGTTGTACCTTGGGTAGATGATAAATCAGG
TATTAACGGTTATATTAGCCGTGATATTATGGACGCGTACTTTGAGTTGAAAAAAATAGAAAATGGCGAAGCTACTAAAG
ATGAAATAGATAAGAAAAATAAAGAACAAGATGATGAATAA

Upstream 100 bases:

>100_bases
TGTTTTATGCTAGAATAGAAAAAGATGTAAGACAGCAGTGAGGACACCTGTATGAAGGTGTCCCTTTCACATTACATAGC
TGTTGGTAGAGGGGGTTTGT

Downstream 100 bases:

>100_bases
AAAGTTGTAAAAAAAGCACACTATCTGAAAAGATAGTGTGCTTTTTTTTATGGTTCATGCATACGTTTTAATAAAGCGGA
CAAGCATATCATATCGGGAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNA
AVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQR
NRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLFRSVLGG
VSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNLTIDMEL
QKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTG
YQTNAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIPQKAFDTMRYYF
GQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAKQDEVGK
VVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNL
TLVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFELKKIENGEATKDEIDKKNKEQDDE

Sequences:

>Translated_706_residues
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNA
AVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQR
NRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLFRSVLGG
VSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNLTIDMEL
QKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTG
YQTNAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIPQKAFDTMRYYF
GQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAKQDEVGK
VVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNL
TLVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFELKKIENGEATKDEIDKKNKEQDDE
>Mature_705_residues
SKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNAA
VRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRN
RVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLFRSVLGGV
STSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNNLNLTIDMELQ
KRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSMAGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTGY
QTNAIQPGSVQLDEPIRLKGTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIPQKAFDTMRYYFG
QFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPSAKQDEVGKV
VHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAKYFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNLT
LVGYAPLEDPEVAFSVVVPWVDDKSGINGYISRDIMDAYFELKKIENGEATKDEIDKKNKEQDDE

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=526, Percent_Identity=25.6653992395437, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1786272, Length=403, Percent_Identity=26.7990074441687, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79453; Mature: 79322

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTIS
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCC
NPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRD
CCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCC
KKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAKDLEVLA
CCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEEEE
IKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLFRSVLGG
EEECCCCCEECCHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
VSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILET
CCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEE
INVSKGQSGNNLNLTIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSM
EECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
AGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTGYQTNAIQPGSVQLDEPIRLK
HHHHHHHCCCCCCHHHHEEHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEECCCCEEEC
GTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIPQKAFDTMRYYF
CCCCCCCCCCCCHHHHHHHEEECCCEEEEEEHHHHCCCCEECCCCCCCCHHHHHHHHHHH
GQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRM
HHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEE
QPQVVKEIRQPSAKQDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAK
CHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHH
YFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNLTLVGYAPLEDPEVAFSVVVP
HHCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEE
WVDDKSGINGYISRDIMDAYFELKKIENGEATKDEIDKKNKEQDDE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTIS
CCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCC
NPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRD
CCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCC
KKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAKDLEVLA
CCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEEEE
IKSKMDGGYAMTPQVIKKDATEQEYAIISENLATLPGVDTNVDWDRKYIYDDLFRSVLGG
EEECCCCCEECCHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
VSTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILET
CCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEE
INVSKGQSGNNLNLTIDMELQKRVEEIITKNLLRYKGGQPYLDRAFVVMMNPKNGEVLSM
EECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
AGKQLVEENGETKVQDFALGTMTSSYPMGSTVKGATVLTGYQTNAIQPGSVQLDEPIRLK
HHHHHHHCCCCCCHHHHEEHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEECCCCEEEC
GTPPKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIPQKAFDTMRYYF
CCCCCCCCCCCCHHHHHHHEEECCCEEEEEEHHHHCCCCEECCCCCCCCHHHHHHHHHHH
GQFGLGVKTGIDLPNESAGQTGRGNQPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRM
HHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEE
QPQVVKEIRQPSAKQDEVGKVVHSMEPKVLNRIDMPESQIKRVQEGFRQVFNDSGGTAAK
CHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHH
YFAGAPYKAAGKTGTAQTVYGGDKEIGKKANGERKETYNLTLVGYAPLEDPEVAFSVVVP
HHCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEE
WVDDKSGINGYISRDIMDAYFELKKIENGEATKDEIDKKNKEQDDE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]