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The map label for this gene is ugd [H]

Identifier: 52140366

GI number: 52140366

Start: 4981815

End: 4983203

Strand: Reverse

Name: ugd [H]

Synonym: BCZK4894

Alternate gene names: 52140366

Gene position: 4983203-4981815 (Counterclockwise)

Preceding gene: 52140362

Following gene: 52140368

Centisome position: 94.01

GC content: 35.64

Gene sequence:

>1389_bases
ATGCACAGGGAGAATTCTATGTATTCGTATATTTTCTATTGTATATTCCTGTGCGAAAAGGAAATGAAAATTACGATAAT
AGGTACCGGATACGTTGGGTTGATTACAGGGGTAGGATTGGCAGTATTGGGACATTCGGTTACATGTTTTGATATAAATG
ATGAGAAAATTGAACGGATAAAACAAGGAGATCTGCCTATTTATGAAGCTGGCTTATATGAATTAATACATGATGCGTGT
GAGAATAATCGTTTAACTTTTACAACAAGTAAAGAGGAAGCATTTAACGATGCAGAATTTATATTTATTGCAGTTGGAAC
GCCATCGTTATTAGATGGGACAGCGGATTTAACATATATTCAAAACGCATGTGTTGATATTGGGACATATGCGACTAAAG
ACATTATTGTTGTTACAAAAAGTACTGTTCCTGTAGGGACGAATGGTGCTATGAGGGGATGGATTGAGGAGACATTACAA
AACAGACATGAATTACATATTGTATCGAATCCTGAATTTTTACGAGAGGGTTCAGGGATTTACGATTTTTTTCAGGGAGA
TCGTATTGTAATTGGGGCTGATAATGAGGAAGCGGCACGAAAAGTGGAGAATTTATATAGTGAATTACACTTAAAAACAT
ATGTTACAGATATAAAAAGTGCAGAGATGATTAAATATGCATCGAATGCTTTTTTAGCGACAAAAATTAGTTTTATCAAT
GAAATTTCAAATATATGTGAGAAGGTAGGAGCAAATGTATTAGACGTCGCAAAAGGGATGGGAATGGATAAGAGAATTGG
AGCGTCTTTTTTAAATGCGGGCATTGGTTACGGGGGATCGTGTTTTCCGAAAGATACGAAAGCGCTTGTGCAAATTGCAG
GGAATGTGGCACATGATTTTCGCTTGTTAAAAGCCGTCATTGAAGTGAATAATAAACAACAGTTATTATTGATTGAGAAA
GCGAAGAAAGTAATAAATATGAACAAGAAGCGGATTGCAGTACTGGGAGCGGCATTTAAACCGAATACAGATGATATAAG
AGATGCACCGTCCCTTATTATGATACAAGAGTTAATAAATCTAGGTGCGGACATAGTTCTATATGACCCGAAGGCGATTC
AAAATATGAAAAATATCTTTGGGGAGACTATACAATATAGTAAATGTATAGATGAATCGATTAGAGGAGCGAGTGCGGCT
TTTATCATGACAGAATGGGAAGCTATCCGAACTTACCCGTTAGAAAAGTACGTACAACTTATGAGAGAACCTATTTTATT
CGATGGAAGAAATTGTTATACTAATGAAGATGTAAAGAAGCAAGGAATAGATTATTATTCTGTTGGAAGAGAAAGTGTCT
ATAAGAGGGATTTTTCCGTTATTCGTTAA

Upstream 100 bases:

>100_bases
GAAGAATATCTAATTTTACAAAAACTTAAAAAAGAATGAAGAAAGTAATTCATATAATAAAGAAGTAAAAGAGTTTTCTC
ATTTTTAAGGTGAGAGGAGG

Downstream 100 bases:

>100_bases
AAGGTATGTATTCATGTATATTCTTATATGTCATAATAGGATTTGTAACTAGTGAAAGAAAAGAGGCAATGAAATGACTG
AACGTTTAAAAGTAATGACA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFNDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSKCIDESIRGASAA
FIMTEWEAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESVYKRDFSVIR

Sequences:

>Translated_462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFNDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSKCIDESIRGASAA
FIMTEWEAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESVYKRDFSVIR
>Mature_462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFNDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSKCIDESIRGASAA
FIMTEWEAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESVYKRDFSVIR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=472, Percent_Identity=34.7457627118644, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI296040443, Length=467, Percent_Identity=31.0492505353319, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=34.5945945945946, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1788340, Length=360, Percent_Identity=30.5555555555556, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI48994968, Length=354, Percent_Identity=30.5084745762712, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=466, Percent_Identity=33.2618025751073, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=33.9055793991416, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51702; Mature: 51702

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERI
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHH
KQGDLPIYEAGLYELIHDACENNRLTFTTSKEEAFNDAEFIFIAVGTPSLLDGTADLTYI
HCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHH
QNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGI
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCE
YDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDF
HHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLLKAVIEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELIN
HHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHH
LGADIVLYDPKAIQNMKNIFGETIQYSKCIDESIRGASAAFIMTEWEAIRTYPLEKYVQL
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHH
MREPILFDGRNCYTNEDVKKQGIDYYSVGRESVYKRDFSVIR
HHCCCEECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERI
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHH
KQGDLPIYEAGLYELIHDACENNRLTFTTSKEEAFNDAEFIFIAVGTPSLLDGTADLTYI
HCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHH
QNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGI
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCE
YDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDF
HHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLLKAVIEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELIN
HHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHH
LGADIVLYDPKAIQNMKNIFGETIQYSKCIDESIRGASAAFIMTEWEAIRTYPLEKYVQL
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHH
MREPILFDGRNCYTNEDVKKQGIDYYSVGRESVYKRDFSVIR
HHCCCEECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]