Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 52140227

GI number: 52140227

Start: 5133704

End: 5134561

Strand: Reverse

Name: fba [H]

Synonym: BCZK5035

Alternate gene names: 52140227

Gene position: 5134561-5133704 (Counterclockwise)

Preceding gene: 52140225

Following gene: 52140226

Centisome position: 96.86

GC content: 41.72

Gene sequence:

>858_bases
ATGCCTTTAGTTTCTATGAAAGAAATGCTAAACAAAGCACTAGAAGGAAAATACGCAGTTGGTCAATTCAACATGAACAA
CTTAGAGTGGACTCAAGCTATCTTAGCTGCTGCGGAAGAAGAAAAATCTCCTGTAATCTTAGGTGTATCTGAGGGTGCAG
CTCGTCATATGACTGGTTTCAAAACAGTTGTAGCTATGGTTAAAGCTTTAATCGAAGAAATGAACATCTCTGTTCCTGTA
GCGATTCACCTTGACCATGGTTCAAGCTTCGAAAAATGTAAAGAAGCAATCGATGCAGGTTTCACATCTGTAATGATCGA
CGCTTCTCACCACCCATTCGAAGAAAACGTAGAAACTACTAAAAAAGTAGTAGAATACGCACACGCTCGTAACGTATCTG
TTGAAGCTGAGCTTGGAACAGTTGGCGGACAAGAAGACGACGTAATCGCTGAAGGCGTAATTTACGCTGACCCAGCTGAG
TGTAAGCACCTTGTTGAAGCAACAGGTATCGATTGCCTAGCTCCAGCTTTAGGTTCTGTACACGGTCCTTACAAAGGTGA
GCCTAACTTAGGATTCGCTGAAATGGAACAAGTTCGTGACTTCACTGGCGTACCTTTAGTATTACACGGTGGTACTGGTA
TCCCAACTGCTGATATCGAAAAAGCTATCTCTTTAGGTACTTCAAAAATCAACGTAAACACTGAGAACCAAATCGAGTTT
ACAAAAGCTGTTCGTGAAGTATTAAACAAAGACCAAGAAGTTTACGATCCTCGTAAATTTATCGGACCTGGCCGCGACGC
TATCAAAGCAACTGTTATTGGTAAAATTCGCGAATTCGGTTCTAACGGTAAAGCGTAA

Upstream 100 bases:

>100_bases
AAGTCCGGTACGTAGATATACATATTTTACCTTATTCTGGTCATACTACCAGCGATAAGAACTTATCGGATACAAAAAAC
GTTTTTTAGGAGGATTCACC

Downstream 100 bases:

>100_bases
GAATAAAATTCCGTTTTGGAAACCGTCTACTCTTTTAGACGGTTTCCTTTCGTTGTATAATGAAAGCGTGAACAAGTCTA
AAGATTTTATCATTTTGTTT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNISVPV
AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAE
CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF
TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA

Sequences:

>Translated_285_residues
MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNISVPV
AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAE
CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF
TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA
>Mature_284_residues
PLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNISVPVA
IHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAEC
KHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEFT
KAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=287, Percent_Identity=41.8118466898955, Blast_Score=233, Evalue=8e-63,
Organism=Escherichia coli, GI1789526, Length=286, Percent_Identity=40.9090909090909, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1788072, Length=285, Percent_Identity=41.0526315789474, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789293, Length=338, Percent_Identity=25.1479289940828, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=333, Percent_Identity=26.1261261261261, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30659; Mature: 30528

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGF
CCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
KTVVAMVKALIEEMNISVPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETT
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
KKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAECKHLVEATGIDCLAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCHHCCCEEEECHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF
CCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEECCCCCHHHH
TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA
HHHHHHHHCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGF
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
KTVVAMVKALIEEMNISVPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETT
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
KKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVIYADPAECKHLVEATGIDCLAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCHHCCCEEEECHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF
CCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEECCCCCHHHH
TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA
HHHHHHHHCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA