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The map label for this gene is pyrG [H]

Identifier: 52140223

GI number: 52140223

Start: 5135899

End: 5137506

Strand: Reverse

Name: pyrG [H]

Synonym: BCZK5038

Alternate gene names: 52140223

Gene position: 5137506-5135899 (Counterclockwise)

Preceding gene: 52140221

Following gene: 52140225

Centisome position: 96.92

GC content: 39.93

Gene sequence:

>1608_bases
ATGACTAAGTATATTTTTGTAACAGGCGGTGTAGTATCGTCTTTAGGTAAAGGTATTACAGCAGCATCTCTTGGACGACT
TTTAAAAAATCGTGGTTTAAATGTAACGATTCAAAAATTTGATCCATACATTAACGTAGACCCAGGGACTATGAGCCCAT
ACCAACACGGTGAGGTATTCGTAACAGATGATGGTGCAGAAACTGACTTAGACCTTGGTCACTATGAGCGTTTCATCGAC
ATCAACTTAAACAAATACAGCAACGTAACAACGGGTAAAATTTACTCTTCAGTTCTTCAAAAAGAGCGTCGTGGTGAATA
CCTAGGAGGAACAGTTCAAGTTATTCCTCACATTACTAACGAAATTAAAGAGCGCGTATACCGTTCTGGTCGCGAAACAA
ACGCGGATGTTGTTATTACAGAAATTGGTGGAACTGTTGGTGACATCGAGTCTCTACCATTCTTAGAAGCAATCCGTCAA
ATTAAGAGCGACATCGGTCGTGATAATGTAATGTACATTCACTGTACGTTAATCCCGTACTTAAAAGCAGCGGGTGAAAT
GAAAACAAAACCAACGCAACATAGCGTTAAAGAGCTTCGCAGCTTAGGTATTCAACCAAATATTATCGTTGTTCGTACAG
AAATGCCTGTTTCTCAAGATATGAAAGACAAGCTTGCATTATTCTGTGACATTGATACAAAAGCAGTTATTGAAGCACGC
GATGCAGATACTTTATATGCGGTTCCATTATCTCTTCAAGAGCAAAATATGGACCAAATCGTTTGCGATCACTTAAAATT
AGACAATCCAGCTGCAGATATGACAGAGTGGACTGCGTTAGTTGAAAAAGTGCGTAACCTTTCTAAGAAAACAAAAATCG
CTCTTGTTGGTAAATACGTAGAGCTTCAAGATGCATACATTTCTGTTGTAGAAGCACTTCGTCATGCAGGTTACTCTTTC
GACACAGATGTAGAAGTGAAATGGGTAAACGCTGAGCATGTAACAGCAGAGAACGTACAAGAATTAGTTGGTGACACAGA
CGGTATCCTTGTACCAGGTGGCTTCGGCGATCGTGGTGTAGAAGGTAAAATCGTTGCAATTCAATATGCTCGTGAAAACA
AAGTTCCATTCTTAGGAATTTGCTTAGGTATGCAACTTGCATCAATCGAATTTGCACGTAACGTATTAGGATTAGAAGGA
GCTAACTCTTCTGAAATTAATCCTGACACACCGTATGCAATCATTGACTTATTACCAGAACAAAAAGATGTAGAAGACTT
AGGTGGTACACTTCGTCTTGGTCTATACCCATGTAAGCTTTCTGAAGAAACAAATGCTTACAATGCTTACAATGAGCCGG
TTGTATATGAGCGTCATCGTCATCGTTATGAGTTCAACAATCAATTCCGTCCGGATATGGAAAAAGCAGGATTTGTATTC
TCTGGTACAAGCCCAGACGGTCGTCTAGTTGAAATCATTGAATTAAAAGATCACCCTTGGTTCGTGGCAGCACAGTTCCA
CCCAGAACTAGTTTCTCGTCCAAACCGTCCACAACCATTGTTCCATGACTTCGTAAGAGCTTCTATTACGAATAAAGAGA
GCAAGTAA

Upstream 100 bases:

>100_bases
AATAAAAAGAGTCTAACAATAAGATGGATACAGTGTTATCTACATACGTTGCGCTTTGCAACGGTGATTATATAACAGCA
AAATAGAAGGGAGCTTTTTC

Downstream 100 bases:

>100_bases
TAAAAAAAGCGCCTGAAATAGGGCGCTTTTTTTAATATTCATTTAACATTTCATCGATTGTAAATTTGATACCGTGATAT
GTAAATAAAGCTATGATTAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSF
DTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEG
ANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVRASITNKESK

Sequences:

>Translated_535_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSF
DTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEG
ANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVRASITNKESK
>Mature_534_residues
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDI
NLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQI
KSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEARD
ADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSFD
TDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGA
NSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVFS
GTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVRASITNKESK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=45.6363636363636, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=45.7350272232305, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=45.7350272232305, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=45.7350272232305, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=55.8659217877095, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI25148299, Length=601, Percent_Identity=40.5990016638935, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=45.2762923351159, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=43.9285714285714, Blast_Score=476, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=47.005444646098, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=44.9596774193548, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59782; Mature: 59650

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEC
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEHH
ELQDAYISVVEALRHAGYSFDTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPE
CCEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
QKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
CCCHHHCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCCCHHHCCEEE
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVRASITNKESK
ECCCCCCCEEEEEEECCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEC
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEHH
ELQDAYISVVEALRHAGYSFDTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPE
CCEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
QKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
CCCHHHCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCCCHHHCCEEE
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVRASITNKESK
ECCCCCCCEEEEEEECCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA