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The map label for this gene is yfmO [H]

Identifier: 52140192

GI number: 52140192

Start: 5179965

End: 5181128

Strand: Reverse

Name: yfmO [H]

Synonym: BCZK5068

Alternate gene names: 52140192

Gene position: 5181128-5179965 (Counterclockwise)

Preceding gene: 52140193

Following gene: 52140194

Centisome position: 97.74

GC content: 37.54

Gene sequence:

>1164_bases
ATGGAGAGCAAACAAAAACTAGGGAGATTGATTACAGTGTTGGCTACTTTCCTTGCCTTTTCAGGTATAGGGGTAGTCGA
CCCAATTTTGCCAATTATTGCTGAAAAGATTGGTGCATCGCATTGGCAAGTAGAGATGTTATTTACAGCATATATTTTAA
CGATGGCAATTATGATGTTACCAGCCGGTATATTTGCATCAAGATTTGGTGATAAACGAATGATGACAATCGGTCTTGCA
ATCGTAACTGTATTTGCGTTTATATGCGGTATATCGCAAACGATTGCTCAATTATCTCTTTTCCGTGCTGGATGGGGATT
AGGAAATGCGATGTTCTTCGCAACGGCGATGACTTTATTGATTGCATTAAGTAAAGAAGTTCATGAAGCAGTAGGATTAT
ATGAAGCAGCTATCGGCTTAGGTATGGCGGGCGGACCGTTATTAGGCGGGATATTAGGTGGACATTCTTGGCGGTATCCA
TTTTTCGCAACGAGTATTTTAATTTTCTTAGCATTTATTTTAGTTTTCTTTTTTGTGAAAGAACCAGAGCGAAAAGTGAA
GCGTAAAGCGGCAGGCGTAGGAGAATTACTTAACCTGGTGAAATATAAACCGTTTATGCAAGGTGCAATTTCAGGAATGT
TATACTACTACGGATTTTTCGTTGTGTTAGCATATTCACCACTTATTATGCATTTATCAGCTATTCAATTAGGTTTTGTA
TTTTGCGGATGGGGACTCGCGTTAGCTTACGGTTCTGCAATTTTAGCACATAAGCTAGAAGGGAAATATGAGCCGAAAGC
ATTGTTGAAAGCCAGTTTACTCGTATTTGCGATTTTCTTAATTGCATTATTCTTTGTGAAAGTTATGTGGTTACAAATTG
TATTAATTGTTCTATCAGGATTAGCATCTGGATTAAATAATGCATTATTTACAAGTTATGTAATGGATATTTCACCTTAT
GAAAGATCTGTTACGTCAGGTGTTTATAACTTCGTTCGTTGGTTAGGGGGCGCAATTGCTCCGATTTTATCAGGAATTAT
CGGTCATACTGTTTCACCACAAAGTCCGTTTTTAGTAGGCGGAATTGTGGTATTAGTTGGTTGTATTATGATCCTAATTC
CAATTCGTAAACCAGTAGAAATAGAGACAAAAGCCCTTTCTTAA

Upstream 100 bases:

>100_bases
ACGAGAAAATGGAGCAAATGCAGCGTGTGAAGGCCGAACTTGAGGATAGCTTACATCGTGCAGTGACATTTTTAGAGAAT
ACAAAAGGAGAGTAATCAAA

Downstream 100 bases:

>100_bases
GAAAGGGTTTTCTTTATATGTATATGTTAGAACGCTCTGACTAAAATATATTTTCGGTATTTTTGTACTTTTAACTATAC
ATTTTGGATGTTTTGTTTTA

Product: multidrug resistance protein; permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MESKQKLGRLITVLATFLAFSGIGVVDPILPIIAEKIGASHWQVEMLFTAYILTMAIMMLPAGIFASRFGDKRMMTIGLA
IVTVFAFICGISQTIAQLSLFRAGWGLGNAMFFATAMTLLIALSKEVHEAVGLYEAAIGLGMAGGPLLGGILGGHSWRYP
FFATSILIFLAFILVFFFVKEPERKVKRKAAGVGELLNLVKYKPFMQGAISGMLYYYGFFVVLAYSPLIMHLSAIQLGFV
FCGWGLALAYGSAILAHKLEGKYEPKALLKASLLVFAIFLIALFFVKVMWLQIVLIVLSGLASGLNNALFTSYVMDISPY
ERSVTSGVYNFVRWLGGAIAPILSGIIGHTVSPQSPFLVGGIVVLVGCIMILIPIRKPVEIETKALS

Sequences:

>Translated_387_residues
MESKQKLGRLITVLATFLAFSGIGVVDPILPIIAEKIGASHWQVEMLFTAYILTMAIMMLPAGIFASRFGDKRMMTIGLA
IVTVFAFICGISQTIAQLSLFRAGWGLGNAMFFATAMTLLIALSKEVHEAVGLYEAAIGLGMAGGPLLGGILGGHSWRYP
FFATSILIFLAFILVFFFVKEPERKVKRKAAGVGELLNLVKYKPFMQGAISGMLYYYGFFVVLAYSPLIMHLSAIQLGFV
FCGWGLALAYGSAILAHKLEGKYEPKALLKASLLVFAIFLIALFFVKVMWLQIVLIVLSGLASGLNNALFTSYVMDISPY
ERSVTSGVYNFVRWLGGAIAPILSGIIGHTVSPQSPFLVGGIVVLVGCIMILIPIRKPVEIETKALS
>Mature_387_residues
MESKQKLGRLITVLATFLAFSGIGVVDPILPIIAEKIGASHWQVEMLFTAYILTMAIMMLPAGIFASRFGDKRMMTIGLA
IVTVFAFICGISQTIAQLSLFRAGWGLGNAMFFATAMTLLIALSKEVHEAVGLYEAAIGLGMAGGPLLGGILGGHSWRYP
FFATSILIFLAFILVFFFVKEPERKVKRKAAGVGELLNLVKYKPFMQGAISGMLYYYGFFVVLAYSPLIMHLSAIQLGFV
FCGWGLALAYGSAILAHKLEGKYEPKALLKASLLVFAIFLIALFFVKVMWLQIVLIVLSGLASGLNNALFTSYVMDISPY
ERSVTSGVYNFVRWLGGAIAPILSGIIGHTVSPQSPFLVGGIVVLVGCIMILIPIRKPVEIETKALS

Specific function: Acts to efflux copper or a copper complex. It is possible that yfmO could contribute to copper resistance [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=158, Percent_Identity=29.746835443038, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41945; Mature: 41945

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKQKLGRLITVLATFLAFSGIGVVDPILPIIAEKIGASHWQVEMLFTAYILTMAIMML
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
PAGIFASRFGDKRMMTIGLAIVTVFAFICGISQTIAQLSLFRAGWGLGNAMFFATAMTLL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IALSKEVHEAVGLYEAAIGLGMAGGPLLGGILGGHSWRYPFFATSILIFLAFILVFFFVK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
EPERKVKRKAAGVGELLNLVKYKPFMQGAISGMLYYYGFFVVLAYSPLIMHLSAIQLGFV
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCGWGLALAYGSAILAHKLEGKYEPKALLKASLLVFAIFLIALFFVKVMWLQIVLIVLSG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASGLNNALFTSYVMDISPYERSVTSGVYNFVRWLGGAIAPILSGIIGHTVSPQSPFLVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GIVVLVGCIMILIPIRKPVEIETKALS
HHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MESKQKLGRLITVLATFLAFSGIGVVDPILPIIAEKIGASHWQVEMLFTAYILTMAIMML
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
PAGIFASRFGDKRMMTIGLAIVTVFAFICGISQTIAQLSLFRAGWGLGNAMFFATAMTLL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IALSKEVHEAVGLYEAAIGLGMAGGPLLGGILGGHSWRYPFFATSILIFLAFILVFFFVK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
EPERKVKRKAAGVGELLNLVKYKPFMQGAISGMLYYYGFFVVLAYSPLIMHLSAIQLGFV
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCGWGLALAYGSAILAHKLEGKYEPKALLKASLLVFAIFLIALFFVKVMWLQIVLIVLSG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASGLNNALFTSYVMDISPYERSVTSGVYNFVRWLGGAIAPILSGIIGHTVSPQSPFLVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GIVVLVGCIMILIPIRKPVEIETKALS
HHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]