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The map label for this gene is ung [H]

Identifier: 52140166

GI number: 52140166

Start: 5204207

End: 5204884

Strand: Reverse

Name: ung [H]

Synonym: BCZK5096

Alternate gene names: 52140166

Gene position: 5204884-5204207 (Counterclockwise)

Preceding gene: 52140167

Following gene: 52140173

Centisome position: 98.19

GC content: 35.69

Gene sequence:

>678_bases
ATGGAAAAGGTTTTGAAAAATGATTGGGGGCCATTATTGGCACCAGAATTTGAGAAAGAATATTATCGTAAGCTAGCTGA
TTTTTTGAAAGAAGAGTACAGTACACATGTTGTTTACCCAAAGAAAGAAGATATTTTTAACGCTCTAGAGTATACAAGTT
ATGAAAATACAAAGGTCGTTATTTTAGGACAAGATCCATATCATGGACCAAATCAAGCGCATGGTTTAAGCTTTTCTGTG
CAACCCGGTATTAAAACGCCACCGTCGTTGTTAAATATGTATAAAGAACTTCGAGATGAATATGGGTATGATATTCCAAA
TAACGGTTATTTAGTAAAGTGGGCAGAGCAAGGCGTTTTATTATTAAATACTGTATTAACAGTTCGACAAGGTGAAGCAA
ATTCTCATAAGGGAAAAGGATGGGAGCATTTCACAGATCGCGTAATTGAGCTATTAAATGAACGTGAAAAGCCAGTTATT
TTCATATTGTGGGGACGCCATGCACAGGCGAAGAAAAAATTAATTACAAATACGAAGCACCACATTATCGAATCTGTACA
TCCAAGCCCACTATCAGCAAGACGTGGTTTCTTTGGTAGTAAGCCGTATTCTAAAGTAAATACGATTTTAGCTAATATGG
GCGAAAGAGAAATTGATTGGGAAATTCCAAATTTATAA

Upstream 100 bases:

>100_bases
TTAATGAATTTAACGGTTTGGGCAGTTGTTTCCCTTATCATTTCATTTGTAGTATTTACAAAACAGGATATGGTGAATTA
ATTAGACGGGAAGTGAAAGC

Downstream 100 bases:

>100_bases
ATAGAAAAGGTAGTTAACAGTCGTTAACTACCTTTTTATTATTGTTGCTCGTTCTTTAATTTTGCATCCAGTACAAACGT
ACCAAATGGGATAACTGATG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MEKVLKNDWGPLLAPEFEKEYYRKLADFLKEEYSTHVVYPKKEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGIKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNTKHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL

Sequences:

>Translated_225_residues
MEKVLKNDWGPLLAPEFEKEYYRKLADFLKEEYSTHVVYPKKEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGIKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNTKHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
>Mature_225_residues
MEKVLKNDWGPLLAPEFEKEYYRKLADFLKEEYSTHVVYPKKEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGIKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNTKHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=50.2325581395349, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=50.2325581395349, Blast_Score=220, Evalue=6e-58,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=54.2056074766355, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=49.0740740740741, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=46.4135021097046, Blast_Score=200, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26037; Mature: 26037

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVLKNDWGPLLAPEFEKEYYRKLADFLKEEYSTHVVYPKKEDIFNALEYTSYENTKVV
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGIKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNTKH
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCHHH
HIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
HHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEKVLKNDWGPLLAPEFEKEYYRKLADFLKEEYSTHVVYPKKEDIFNALEYTSYENTKVV
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGIKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNTKH
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCHHH
HIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
HHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA