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The map label for this gene is sppA [H]

Identifier: 51893930

GI number: 51893930

Start: 3007647

End: 3008585

Strand: Reverse

Name: sppA [H]

Synonym: STH2792

Alternate gene names: 51893930

Gene position: 3008585-3007647 (Counterclockwise)

Preceding gene: 51893931

Following gene: 51893929

Centisome position: 84.37

GC content: 70.29

Gene sequence:

>939_bases
GTGAAGAACACCATGAAGCGTTGGATTGCGGCCGGCGCGATCGTCGCCATCGTCGTTTTGTCGCTCGCCGTGGCCTTTTG
GCAGGGCACCGGCCGGGAGGTCGGCAGCCCGAAAGGGCCATCCGGCGGACAGGTGGCCCTGGTGCGGGTGGAGGGGACCA
TCGTGTCCGGGGAAGGCTCCGGCAGCCTCCTGAGCGGCGCCGGCGCCGGTTCGGAGACCATCGTGAAACACCTGGACCGG
GCGGCGGAGGACCCGGCGGTGAAGGCCGTCGTCCTGCGGGTCAACAGCCCGGGCGGAAGCGTGGTCGCCTCCTGGGAGAT
CGCGGAGGCGGTCCGGCGGGTGCAGGACGCCGGGAAGCCGGTGGTGGTCTCCATGGGCGAGAGCGCCGCCTCGGGCGGCT
ACTGGATCTCGGCCGGGGCGGACCGGATCATCGCCAGCCCGGACACGATGACCGGTTCCATCGGGGTCATCCTGCAGGTG
GGGAACCTGTCCGAGGTATATGAGAAGGTCGGCTACAAGACGTACACCTTTAAGAGCGGACCGTTCAAGGACATGGGCAG
CCCGGATCGGGAGATGACCGACGCCGAGCGGGACCTCCTGCAGGACCTGGTGGACGAGACCTACGAGGCCTTCGTCCCGG
TCGTGGCCGAGGGCCGTGGCATGGACGAGGCACAAGTCCGGAAGATCGCCGACGGGCGCATCCTGACCGGCCGGAAGGCG
TTGGAGCTGGGGCTGGTCGATGAGCTGGGCGACCTGAAGCGCGCGGTGCAGGTGGCGGCAGAGCTGGCCGGCCTGCCGGG
GGAGCCGGAAGTGCGGGAGATGAACCGCGCCAACGGGCTGTTGGGGGCTCTGCTGGGCCGGGGGATCCTCCCGCCCGCCT
CCCTGGGGCTGCCGAGCGGCCTGTACGCCCTGGAGCCGGGGCCGGTGAGCATCCGTTAG

Upstream 100 bases:

>100_bases
TCAGCCTGGCCCTCGGCGGCCTGAGCCTGACCCTGGGGCCGTGGATCAGGCGCATCGCGCGAGAGGACTAGAAGGAAGCT
GACAAATCCCCTGAAGAGGA

Downstream 100 bases:

>100_bases
TGCGAGTGGAGGGTTAGACCGATGACGGAACCGTCTGCGCAGAACGGCGCGACTTCGGTGTGGGATCTGATGCTCGACGT
CTTCATCGCCCCGGGGAGGG

Product: putative proteinase IV

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKNTMKRWIAAGAIVAIVVLSLAVAFWQGTGREVGSPKGPSGGQVALVRVEGTIVSGEGSGSLLSGAGAGSETIVKHLDR
AAEDPAVKAVVLRVNSPGGSVVASWEIAEAVRRVQDAGKPVVVSMGESAASGGYWISAGADRIIASPDTMTGSIGVILQV
GNLSEVYEKVGYKTYTFKSGPFKDMGSPDREMTDAERDLLQDLVDETYEAFVPVVAEGRGMDEAQVRKIADGRILTGRKA
LELGLVDELGDLKRAVQVAAELAGLPGEPEVREMNRANGLLGALLGRGILPPASLGLPSGLYALEPGPVSIR

Sequences:

>Translated_312_residues
MKNTMKRWIAAGAIVAIVVLSLAVAFWQGTGREVGSPKGPSGGQVALVRVEGTIVSGEGSGSLLSGAGAGSETIVKHLDR
AAEDPAVKAVVLRVNSPGGSVVASWEIAEAVRRVQDAGKPVVVSMGESAASGGYWISAGADRIIASPDTMTGSIGVILQV
GNLSEVYEKVGYKTYTFKSGPFKDMGSPDREMTDAERDLLQDLVDETYEAFVPVVAEGRGMDEAQVRKIADGRILTGRKA
LELGLVDELGDLKRAVQVAAELAGLPGEPEVREMNRANGLLGALLGRGILPPASLGLPSGLYALEPGPVSIR
>Mature_312_residues
MKNTMKRWIAAGAIVAIVVLSLAVAFWQGTGREVGSPKGPSGGQVALVRVEGTIVSGEGSGSLLSGAGAGSETIVKHLDR
AAEDPAVKAVVLRVNSPGGSVVASWEIAEAVRRVQDAGKPVVVSMGESAASGGYWISAGADRIIASPDTMTGSIGVILQV
GNLSEVYEKVGYKTYTFKSGPFKDMGSPDREMTDAERDLLQDLVDETYEAFVPVVAEGRGMDEAQVRKIADGRILTGRKA
LELGLVDELGDLKRAVQVAAELAGLPGEPEVREMNRANGLLGALLGRGILPPASLGLPSGLYALEPGPVSIR

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=275, Percent_Identity=37.0909090909091, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1787527, Length=162, Percent_Identity=32.0987654320988, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 32387; Mature: 32387

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTMKRWIAAGAIVAIVVLSLAVAFWQGTGREVGSPKGPSGGQVALVRVEGTIVSGEGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCC
GSLLSGAGAGSETIVKHLDRAAEDPAVKAVVLRVNSPGGSVVASWEIAEAVRRVQDAGKP
CCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCC
VVVSMGESAASGGYWISAGADRIIASPDTMTGSIGVILQVGNLSEVYEKVGYKTYTFKSG
EEEECCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHCCEEEEECCC
PFKDMGSPDREMTDAERDLLQDLVDETYEAFVPVVAEGRGMDEAQVRKIADGRILTGRKA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCHH
LELGLVDELGDLKRAVQVAAELAGLPGEPEVREMNRANGLLGALLGRGILPPASLGLPSG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LYALEPGPVSIR
CEEECCCCCCCC
>Mature Secondary Structure
MKNTMKRWIAAGAIVAIVVLSLAVAFWQGTGREVGSPKGPSGGQVALVRVEGTIVSGEGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCC
GSLLSGAGAGSETIVKHLDRAAEDPAVKAVVLRVNSPGGSVVASWEIAEAVRRVQDAGKP
CCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCC
VVVSMGESAASGGYWISAGADRIIASPDTMTGSIGVILQVGNLSEVYEKVGYKTYTFKSG
EEEECCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHCCEEEEECCC
PFKDMGSPDREMTDAERDLLQDLVDETYEAFVPVVAEGRGMDEAQVRKIADGRILTGRKA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCHH
LELGLVDELGDLKRAVQVAAELAGLPGEPEVREMNRANGLLGALLGRGILPPASLGLPSG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LYALEPGPVSIR
CEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]