BacMap

Definition	Symbiobacterium thermophilum IAM 14863 chromosome, complete genome.
Accession	NC_006177
Length	3,566,135

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The map label for this gene is ppiB [H]

Identifier: 51893763

GI number: 51893763

Start: 2818753

End: 2819259

Strand: Reverse

Name: ppiB [H]

Synonym: STH2625

Alternate gene names: 51893763

Gene position: 2819259-2818753 (Counterclockwise)

Preceding gene: 51893764

Following gene: 51893761

Centisome position: 79.06

GC content: 65.68

Gene sequence:

>507_bases
ATGGAAATCGACCCGTCCAAGCGGTACCGGGCGACCCTGAGAACCACTAAGGGTGAGATCGTCATCGACCTGTTCGCGGA
CGAGGCCCCGCTCGCCGTCAACAACTTCGTCTTCCTGGCGCGCCAGGGGTATTACGACGGGGTGAAGTTTCACCGGGTCA
TCAAGCCCTTCATGATCCAGACCGGCGATCCGACGGGCACCGGCCGGGGTGGCCCGGGCTACCGGTTTCCCGATGAGCTG
CCGCCCAAGCACCCCTATGAGCCGGGCATCGTCGCGATGGCCAACGCCGGCCCCAACACCAACGGCAGCCAGTTCTTCAT
CTGCTCCGGTCCGCAGGCGGCCGGCCTGAACCACTTCCCGCATTACACCCAGTTCGGCCGTGTGGTGGAGGGGATGGATG
TGGTGGAGGCGCTGGCGTCGGTGCCGGTCGGCCCGGCCTTCAACGGGGAGATGTCCCGGCCTCTGGAGGAGATCCGGATC
GAATCGGTGCGCATCAGCGAGCTGTAG

Upstream 100 bases:

>100_bases
TTCCGGGAAAACGGCATCGCGCTGGCGATTCCTGCGCAACATATCCGCATCCAGCAGAAGGAGGATTCCCTTGACCAGGC
AGTGGAGCTCCCCGCCCCCG

Downstream 100 bases:

>100_bases
CCGTGAGGCGCGCAGAAGGCCCCCGCGGCGCATCGGCGCCGGCGGGGGCCCTGGCGTGCACGACGGTTGCATTCAGTCCT
GGAAGGGCTGTCGTTCACCG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MEIDPSKRYRATLRTTKGEIVIDLFADEAPLAVNNFVFLARQGYYDGVKFHRVIKPFMIQTGDPTGTGRGGPGYRFPDEL
PPKHPYEPGIVAMANAGPNTNGSQFFICSGPQAAGLNHFPHYTQFGRVVEGMDVVEALASVPVGPAFNGEMSRPLEEIRI
ESVRISEL

Sequences:

>Translated_168_residues
MEIDPSKRYRATLRTTKGEIVIDLFADEAPLAVNNFVFLARQGYYDGVKFHRVIKPFMIQTGDPTGTGRGGPGYRFPDEL
PPKHPYEPGIVAMANAGPNTNGSQFFICSGPQAAGLNHFPHYTQFGRVVEGMDVVEALASVPVGPAFNGEMSRPLEEIRI
ESVRISEL
>Mature_168_residues
MEIDPSKRYRATLRTTKGEIVIDLFADEAPLAVNNFVFLARQGYYDGVKFHRVIKPFMIQTGDPTGTGRGGPGYRFPDEL
PPKHPYEPGIVAMANAGPNTNGSQFFICSGPQAAGLNHFPHYTQFGRVVEGMDVVEALASVPVGPAFNGEMSRPLEEIRI
ESVRISEL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=164, Percent_Identity=45.1219512195122, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI7706339, Length=153, Percent_Identity=48.3660130718954, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=44.6540880503145, Blast_Score=123, Evalue=9e-29,
Organism=Homo sapiens, GI64276486, Length=124, Percent_Identity=46.7741935483871, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI20911035, Length=159, Percent_Identity=38.3647798742138, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4758950, Length=150, Percent_Identity=44.6666666666667, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=51.1627906976744, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=46.9230769230769, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=43.558282208589, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=43.558282208589, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=43.558282208589, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI10863927, Length=145, Percent_Identity=42.0689655172414, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI256017253, Length=127, Percent_Identity=44.8818897637795, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI221139811, Length=127, Percent_Identity=44.8818897637795, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI256017251, Length=127, Percent_Identity=44.8818897637795, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI178057341, Length=128, Percent_Identity=43.75, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI209417936, Length=128, Percent_Identity=43.75, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI30102944, Length=128, Percent_Identity=43.75, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI219842199, Length=128, Percent_Identity=43.75, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI169164185, Length=145, Percent_Identity=40.6896551724138, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI169163623, Length=145, Percent_Identity=40.6896551724138, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI169163387, Length=145, Percent_Identity=40.6896551724138, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310129267, Length=145, Percent_Identity=38.6206896551724, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI310120620, Length=145, Percent_Identity=38.6206896551724, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI4826932, Length=146, Percent_Identity=41.0958904109589, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310127646, Length=129, Percent_Identity=44.9612403100775, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310114371, Length=129, Percent_Identity=44.9612403100775, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310119221, Length=129, Percent_Identity=44.9612403100775, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310110104, Length=129, Percent_Identity=41.8604651162791, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI5454154, Length=141, Percent_Identity=39.7163120567376, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI42560244, Length=162, Percent_Identity=37.037037037037, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI303305009, Length=144, Percent_Identity=38.1944444444444, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI310132444, Length=128, Percent_Identity=42.1875, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI310113152, Length=128, Percent_Identity=42.1875, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI6631100, Length=167, Percent_Identity=35.3293413173653, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI169214050, Length=154, Percent_Identity=40.2597402597403, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI239751853, Length=154, Percent_Identity=40.2597402597403, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI113428306, Length=154, Percent_Identity=40.2597402597403, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=39.5348837209302, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI5174637, Length=131, Percent_Identity=38.9312977099237, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI14277126, Length=108, Percent_Identity=42.5925925925926, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1786736, Length=168, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=35.2564102564103, Blast_Score=70, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=159, Percent_Identity=42.7672955974843, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17539496, Length=160, Percent_Identity=45.625, Blast_Score=122, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17506311, Length=162, Percent_Identity=46.2962962962963, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71980590, Length=149, Percent_Identity=43.6241610738255, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71997782, Length=124, Percent_Identity=46.7741935483871, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17552780, Length=150, Percent_Identity=45.3333333333333, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=42.4050632911392, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17532641, Length=130, Percent_Identity=43.8461538461538, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563659, Length=159, Percent_Identity=35.8490566037736, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17566266, Length=135, Percent_Identity=44.4444444444444, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17552782, Length=137, Percent_Identity=41.6058394160584, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=40.9090909090909, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=128, Percent_Identity=44.53125, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17565860, Length=137, Percent_Identity=41.6058394160584, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=163, Percent_Identity=35.5828220858896, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17532643, Length=140, Percent_Identity=41.4285714285714, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551282, Length=147, Percent_Identity=40.8163265306122, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551284, Length=147, Percent_Identity=40.8163265306122, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320359, Length=131, Percent_Identity=45.8015267175573, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321848, Length=153, Percent_Identity=41.1764705882353, Blast_Score=88, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323562, Length=154, Percent_Identity=40.9090909090909, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323246, Length=168, Percent_Identity=34.5238095238095, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=134, Percent_Identity=43.2835820895522, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17986117, Length=172, Percent_Identity=43.6046511627907, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652460, Length=159, Percent_Identity=44.0251572327044, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=39.0243902439024, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922912, Length=158, Percent_Identity=48.1012658227848, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357249, Length=160, Percent_Identity=38.125, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664125, Length=130, Percent_Identity=46.9230769230769, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357783, Length=130, Percent_Identity=46.9230769230769, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45549139, Length=131, Percent_Identity=47.3282442748092, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130249, Length=150, Percent_Identity=42, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355677, Length=166, Percent_Identity=35.5421686746988, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24650807, Length=158, Percent_Identity=40.5063291139241, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586038, Length=144, Percent_Identity=38.1944444444444, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=42.96875, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136360, Length=136, Percent_Identity=39.7058823529412, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18439; Mature: 18439

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIDPSKRYRATLRTTKGEIVIDLFADEAPLAVNNFVFLARQGYYDGVKFHRVIKPFMIQ
CCCCCCCHHEEEEECCCCCEEEEEECCCCCEEECCEEEEEECCCCCCHHHHHHHHHHEEE
TGDPTGTGRGGPGYRFPDELPPKHPYEPGIVAMANAGPNTNGSQFFICSGPQAAGLNHFP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCC
HYTQFGRVVEGMDVVEALASVPVGPAFNGEMSRPLEEIRIESVRISEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHCCEEECCC
>Mature Secondary Structure
MEIDPSKRYRATLRTTKGEIVIDLFADEAPLAVNNFVFLARQGYYDGVKFHRVIKPFMIQ
CCCCCCCHHEEEEECCCCCEEEEEECCCCCEEECCEEEEEECCCCCCHHHHHHHHHHEEE
TGDPTGTGRGGPGYRFPDELPPKHPYEPGIVAMANAGPNTNGSQFFICSGPQAAGLNHFP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCC
HYTQFGRVVEGMDVVEALASVPVGPAFNGEMSRPLEEIRIESVRISEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]