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The map label for this gene is aacA4 [H]

Identifier: 51893755

GI number: 51893755

Start: 2813261

End: 2813839

Strand: Reverse

Name: aacA4 [H]

Synonym: STH2617

Alternate gene names: 51893755

Gene position: 2813839-2813261 (Counterclockwise)

Preceding gene: 51893759

Following gene: 51893754

Centisome position: 78.9

GC content: 68.22

Gene sequence:

>579_bases
GTGCAGCAGGAGATCCGCTTTCGCCGCCTGACGGAGGACGATCTGGATCGGATGCACCGCTGGCTCAACACGCCCCACGT
CATGCGCTGGTACAGCCCCGGCGGACGCACCCGGGCACAGGTGGAGCAGGAGTTCGGCCCCTACATCCGCCGGGAGAAGC
CCACCGAGCCGTACCTGATCCTGTACGGGAATACCCCCATAGGGTATATCCAGACCTACCGGATCAATCACTGGCCCGAT
TACGCCCGCCACATCGGCGTGGACGACGATACTGCCGGCGTCGACGTCATCATCGGCGAGCCGGAGTTCGTCGGCCGGGG
GCTGGGACCGGCGGCCATCCGCGCCTTCATGCGGCAGGTGGTCTTCGGTTCGTTCGGGGCGCGGTCATGCGTCATCGGCC
CGGAGGAGGGCAACCTGGCCGCGATCCGGGCCTACGAGAAGGCGGGGTTCCGCTTCTGGAAGCGCGCCGACGTCCCGGGG
GAGCCTGCGCCGGAGTACCTCATGCGCATGACGCCCGAGGACCTGCAGGCGGACGACGTCCACGCCGCCGCCCGGCCAGA
TGCAAACGTGCACCCTTGA

Upstream 100 bases:

>100_bases
CTCCTCCACAAACACGTATTCTTTTAAATACTTCGACAACAAGACGCCGCTCCCTGCTGGTTCGCCCAATCGGGATACGC
ATGAGAGGAGGAGGCAGACT

Downstream 100 bases:

>100_bases
CGCGATGACCGGTTGAAGGCTACGATAGAGTCAAGAACCCATACCCCGTATGGGTACCGAGCGGCAATCCTGCGGGGTTC
GCTCGAGCTCACGCATCTGG

Product: aminoglycoside 6'-N-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MQQEIRFRRLTEDDLDRMHRWLNTPHVMRWYSPGGRTRAQVEQEFGPYIRREKPTEPYLILYGNTPIGYIQTYRINHWPD
YARHIGVDDDTAGVDVIIGEPEFVGRGLGPAAIRAFMRQVVFGSFGARSCVIGPEEGNLAAIRAYEKAGFRFWKRADVPG
EPAPEYLMRMTPEDLQADDVHAAARPDANVHP

Sequences:

>Translated_192_residues
MQQEIRFRRLTEDDLDRMHRWLNTPHVMRWYSPGGRTRAQVEQEFGPYIRREKPTEPYLILYGNTPIGYIQTYRINHWPD
YARHIGVDDDTAGVDVIIGEPEFVGRGLGPAAIRAFMRQVVFGSFGARSCVIGPEEGNLAAIRAYEKAGFRFWKRADVPG
EPAPEYLMRMTPEDLQADDVHAAARPDANVHP
>Mature_192_residues
MQQEIRFRRLTEDDLDRMHRWLNTPHVMRWYSPGGRTRAQVEQEFGPYIRREKPTEPYLILYGNTPIGYIQTYRINHWPD
YARHIGVDDDTAGVDVIIGEPEFVGRGLGPAAIRAFMRQVVFGSFGARSCVIGPEEGNLAAIRAYEKAGFRFWKRADVPG
EPAPEYLMRMTPEDLQADDVHAAARPDANVHP

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 21997; Mature: 21997

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQEIRFRRLTEDDLDRMHRWLNTPHVMRWYSPGGRTRAQVEQEFGPYIRREKPTEPYLI
CCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCHHCCCCCCCCEEE
LYGNTPIGYIQTYRINHWPDYARHIGVDDDTAGVDVIIGEPEFVGRGLGPAAIRAFMRQV
EECCCCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHH
VFGSFGARSCVIGPEEGNLAAIRAYEKAGFRFWKRADVPGEPAPEYLMRMTPEDLQADDV
HHCCCCCCEEEECCCCCCEEEEEHHHHHCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC
HAAARPDANVHP
CCCCCCCCCCCC
>Mature Secondary Structure
MQQEIRFRRLTEDDLDRMHRWLNTPHVMRWYSPGGRTRAQVEQEFGPYIRREKPTEPYLI
CCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCHHCCCCCCCCEEE
LYGNTPIGYIQTYRINHWPDYARHIGVDDDTAGVDVIIGEPEFVGRGLGPAAIRAFMRQV
EECCCCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHH
VFGSFGARSCVIGPEEGNLAAIRAYEKAGFRFWKRADVPGEPAPEYLMRMTPEDLQADDV
HHCCCCCCEEEECCCCCCEEEEEHHHHHCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC
HAAARPDANVHP
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]