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The map label for this gene is apt [H]

Identifier: 51599028

GI number: 51599028

Start: 819893

End: 820423

Strand: Direct

Name: apt [H]

Synonym: BG0801

Alternate gene names: 51599028

Gene position: 819893-820423 (Clockwise)

Preceding gene: 51599027

Following gene: 51599029

Centisome position: 90.67

GC content: 33.52

Gene sequence:

>531_bases
ATGAAAAATAAAACAGAGTATTATGATCAGTTTATTGCAAAAGTACCCGATTTCCCTAAAAAGGGTGTTCTTTTTTACGA
TATTACTAGTGTTTTGTTAAAACCGGAAGTTTATACTTCATTAATAAATGAGGCATATTCTTTTTATAATCTTAAAAAGA
TTGATTGCATTGCTGTTGTTGAGTCCCGGGGGTATTTAATAGGTGCTCCTTTGTCTTTAAAAATGCAACTTCCTCTTGTT
TTAATTCGAAAAGAGGGTAAATTGCCCAGAGAGGTTTTTGGCGAAGAGTATGAGCTTGAATATGGCTTTGGGAAAATAGA
AGTACACAAAGATGATGTTAGGATGTATTCCAATATTCTTTTAATAGATGATATATTGGCTACCGGTGGAACTTTAAAGT
CGTCTGCAATTTTGCTAGAGAGAGCTGGGGGCAGGGTTAAGGATATTTTTTGTTTTATTGAGCTTTGTGGTATTAATGGT
AGACGCATTCTTGAAGACTATGATGTTAATTCTCTTGTAAGGTACAATTAA

Upstream 100 bases:

>100_bases
TTGCTTAATCTTGTTCCATCGCCTCCTTTAAAAGAGTAAATTTGGCTTTTGGTTTTACTATTTTGAAAAATACATAAACA
TATGATGGGATAAGTAGGTT

Downstream 100 bases:

>100_bases
CTTAATGCTTGACTTTTCTTTTTTATTAAATTTACAATGTTTAGTTGAGGTAATGTAATGTATGCATTGGTAGAAATAAA
TGGAAAGCAATATAAGGCTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKNKTEYYDQFIAKVPDFPKKGVLFYDITSVLLKPEVYTSLINEAYSFYNLKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFGEEYELEYGFGKIEVHKDDVRMYSNILLIDDILATGGTLKSSAILLERAGGRVKDIFCFIELCGING
RRILEDYDVNSLVRYN

Sequences:

>Translated_176_residues
MKNKTEYYDQFIAKVPDFPKKGVLFYDITSVLLKPEVYTSLINEAYSFYNLKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFGEEYELEYGFGKIEVHKDDVRMYSNILLIDDILATGGTLKSSAILLERAGGRVKDIFCFIELCGING
RRILEDYDVNSLVRYN
>Mature_176_residues
MKNKTEYYDQFIAKVPDFPKKGVLFYDITSVLLKPEVYTSLINEAYSFYNLKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFGEEYELEYGFGKIEVHKDDVRMYSNILLIDDILATGGTLKSSAILLERAGGRVKDIFCFIELCGING
RRILEDYDVNSLVRYN

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=35.5932203389831, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=37.6923076923077, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=38.4615384615385, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=36.4705882352941, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=158, Percent_Identity=34.8101265822785, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136334, Length=176, Percent_Identity=34.6590909090909, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20151; Mature: 20151

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKTEYYDQFIAKVPDFPKKGVLFYDITSVLLKPEVYTSLINEAYSFYNLKKIDCIAVV
CCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEE
ESRGYLIGAPLSLKMQLPLVLIRKEGKLPREVFGEEYELEYGFGKIEVHKDDVRMYSNIL
ECCCEEEECCEEEEEECCEEEEECCCCCCHHHCCCEEEEEECCCEEEEEHHHHHHHHCCC
LIDDILATGGTLKSSAILLERAGGRVKDIFCFIELCGINGRRILEDYDVNSLVRYN
EEEHHHHCCCCCCHHEEEEECCCCCHHHHEEEEHHHCCCCCEEEECCCCCEEEECC
>Mature Secondary Structure
MKNKTEYYDQFIAKVPDFPKKGVLFYDITSVLLKPEVYTSLINEAYSFYNLKKIDCIAVV
CCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEE
ESRGYLIGAPLSLKMQLPLVLIRKEGKLPREVFGEEYELEYGFGKIEVHKDDVRMYSNIL
ECCCEEEECCEEEEEECCEEEEECCCCCCHHHCCCEEEEEECCCEEEEEHHHHHHHHCCC
LIDDILATGGTLKSSAILLERAGGRVKDIFCFIELCGINGRRILEDYDVNSLVRYN
EEEHHHHCCCCCCHHEEEEECCCCCHHHHEEEEHHHCCCCCEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA