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The map label for this gene is rnc [H]

Identifier: 51598958

GI number: 51598958

Start: 742582

End: 743319

Strand: Direct

Name: rnc [H]

Synonym: BG0727

Alternate gene names: 51598958

Gene position: 742582-743319 (Clockwise)

Preceding gene: 51598957

Following gene: 51598960

Centisome position: 82.12

GC content: 32.79

Gene sequence:

>738_bases
ATGAAAAAAAAATCTTCCGATTTTTGTTTTGGCAGTGAAAGAAAAGCACAATTAAGTGAATTCTTGGAAAATTTGAGCAT
TGATTTTAATAATTTTGATTTACTAAATACGGCATTGAGCCACTCGTCTTATTCTAATGAGTTAGATCAGAAAGCTGACA
ATAATGAGAGATTAGAATTTTTAGGAGATTCTGTGCTTAATTTGATTATCACAGATCATCTTTATAAAACTTATCCAAAT
AAAAGTGAAGGAGAGCTTAGTAAGGCCAGGTCTTATATTGTTAGTGAAGACTCCCTATCTAGTATTGCTAGAGAGATTGA
TCTTGGTTCTTATATTTTACTTGGCAGAGGGGAGGAGAGTAATGATGGTCGCAACAAAAAAGGCATTCTTGCAGATGCTA
TTGAAGCTTTTGTAGGCGCTATTTATCTTGATAGTGGGTTTTCAATGGCAACAGAATTTGTGGTTGGACTTTTTGACATG
TATATAAGATTAATGTTTAATAGAGGTGATTTTAAAGATTATAAGAGCTTGTTGCAAGAATATGTTCAAAAGAAATATAA
AATCTCGCCAAGTTATAAGCTAGACAAGGAAATAGGTCCAGATCATGATAAAGTTTTTTGCGTGGAGCTTTATGTTGGAG
AAAAGTTTATATCAAATGGAAAGGGCAAATCTAAAAAAGAAGCCGAAATGAGAGCTGCTGAAGTAGCTTTAAAGGCTATG
GAAGATATTAATCTTTAG

Upstream 100 bases:

>100_bases
TACTTGAAGAGGCTTTTGATGATAAGATTCCAGAGAACGAAGCCAATGAATTTGAGACAGTAGGTGATGTTGTTAATTTT
ATTAAAAAGAGAAAAGGTTG

Downstream 100 bases:

>100_bases
GGTTTTTATTTTTTTAATAAGATACTTTTTAGTATTAAGTCTGGGATTTTCAATTACATGGTTTAGAAGTATATTTAAAA
TTTTACCTATATTTTTATTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MKKKSSDFCFGSERKAQLSEFLENLSIDFNNFDLLNTALSHSSYSNELDQKADNNERLEFLGDSVLNLIITDHLYKTYPN
KSEGELSKARSYIVSEDSLSSIAREIDLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSMATEFVVGLFDM
YIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGEKFISNGKGKSKKEAEMRAAEVALKAM
EDINL

Sequences:

>Translated_245_residues
MKKKSSDFCFGSERKAQLSEFLENLSIDFNNFDLLNTALSHSSYSNELDQKADNNERLEFLGDSVLNLIITDHLYKTYPN
KSEGELSKARSYIVSEDSLSSIAREIDLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSMATEFVVGLFDM
YIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGEKFISNGKGKSKKEAEMRAAEVALKAM
EDINL
>Mature_245_residues
MKKKSSDFCFGSERKAQLSEFLENLSIDFNNFDLLNTALSHSSYSNELDQKADNNERLEFLGDSVLNLIITDHLYKTYPN
KSEGELSKARSYIVSEDSLSSIAREIDLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSMATEFVVGLFDM
YIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGEKFISNGKGKSKKEAEMRAAEVALKAM
EDINL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=235, Percent_Identity=31.063829787234, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030236, Length=235, Percent_Identity=31.063829787234, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788920, Length=218, Percent_Identity=36.2385321100917, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=245, Percent_Identity=28.1632653061224, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=245, Percent_Identity=28.1632653061224, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137682, Length=243, Percent_Identity=30.4526748971193, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27744; Mature: 27744

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKSSDFCFGSERKAQLSEFLENLSIDFNNFDLLNTALSHSSYSNELDQKADNNERLEF
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGDSVLNLIITDHLYKTYPNKSEGELSKARSYIVSEDSLSSIAREIDLGSYILLGRGEES
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCC
NDGRNKKGILADAIEAFVGAIYLDSGFSMATEFVVGLFDMYIRLMFNRGDFKDYKSLLQE
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGEKFISNGKGKSKKEAEMRAAEVALKAM
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EDINL
HHCCC
>Mature Secondary Structure
MKKKSSDFCFGSERKAQLSEFLENLSIDFNNFDLLNTALSHSSYSNELDQKADNNERLEF
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGDSVLNLIITDHLYKTYPNKSEGELSKARSYIVSEDSLSSIAREIDLGSYILLGRGEES
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCC
NDGRNKKGILADAIEAFVGAIYLDSGFSMATEFVVGLFDMYIRLMFNRGDFKDYKSLLQE
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGEKFISNGKGKSKKEAEMRAAEVALKAM
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EDINL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]