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The map label for this gene is zwf [H]

Identifier: 51598890

GI number: 51598890

Start: 675258

End: 676694

Strand: Direct

Name: zwf [H]

Synonym: BG0658

Alternate gene names: 51598890

Gene position: 675258-676694 (Clockwise)

Preceding gene: 51598884

Following gene: 51598891

Centisome position: 74.68

GC content: 28.04

Gene sequence:

>1437_bases
ATGAAAGAAAAAAGTGTTTCTAATTTTGATATTGTAATTTTTGGAGTTACTGGGAATTTGTCTAGAAAAAAACTTATTCC
TTCACTTTTTAACTTGTTTAAAAATAAATGTATTAGCAATTTTAGGGTTATTGGTTTTTCTCGTAAAATTTTTACAGATA
AAGAATTTAGATTGTATATTAAAGATTCTTTATGGCAGGAAGAGACCGATTCTTTGATTGAAATTTTTTTAAATTTCTTT
ATTTATGTATTTGGTGATTTTAATGAAAATGAGCCTTATATAAAACTATTTAAATTTTTAGATAAAAGTCGAGAAACAAT
ATATTATCTTTCGACGTCTCCTACATTTTATGGCCCAATAATTAATAATTTAAAAAAACATTTTGTAAGCGAAAGATTGA
CTTTATCAAAAATAGTTCTTGAAAAGCCTTTTGGCTCTAGTCTTGAGACAGCAAAAAAATTAAATAGTTTACTTTACTCT
GCTTTTAGAGAAGATCAAATTTATAGAATAGACCACTATTTAGGTAAAGAGACAGTTCAAAATATTTTTACATTTAGATT
CGGCAATTCTATTTTTGAAAATATTTGGAATAATCGTTATGTAGATTTTGTTCAGATTACGGTTGCAGAAGAATTAGGCC
TTGATGGAAGGGCTGAATATTATGATTCTGTTGGTGCTTTAAAGGATATGGTTCAAAACCATATTTTACAATTGTTAAGT
CTTGTTGCAATGGAGTCTCCCATTAAATTTGATTCTGAGTTTATTCATGATGAGAAAGTAAAAGTTTTAAAAAGTTTGAG
GAAAATTAACAGAGAGGATATTAAGAATTGCATTGTTAAGGGGCAATATATAGGTTCACAAGTTCAAGGAGTTTTTAAAA
AAGGCTATAAAGATGAAACAGAATCTTTGGGGAATTCAAATACTGAAACTTATTTAGCCATGAAAGTGTTTATTAATAAT
TGGCGCTGGTCTGGTGTTCCTTTTTATCTTAGAACCGGCAAAGGTCTTGCTAGAAAATTTTCAGAAATATATATTCAATT
TAAAAAACCAAGCTTTACTCTTTTTAACAATAGTTCTGTTGATTTTTCTAATGCCTTAATATTTAGGATTCAACCAAGAG
ATGGAATTGAAATTAAATTCAATACCAAGAAGCCCGGATATAATTATGAAATTCAAACTGCTAATATGGAATTTTCATAT
TACGGGACATTTAAAAGATTGTTTGATGAGGCCTATGAGCGTTTATTGTTAGATGCTTTCTTAGGAGATGGCACTTTGTA
TGCAACAAGCGATGAGATTGAAAGTTCTTGGGAATTCGTTTCAGATATTGCAAATAAATGGGAAGATATTGAAATTTGTA
ATTATTTTTATGGATCTGAAGGACCAAAAGAAATAGATTCTATTTTAGAAAAAGATCATTTTTGGCGTAAAATTTAA

Upstream 100 bases:

>100_bases
ATACTAGTTTTGCTTGTAAAAAAATGATATTTAATTTTTATTTGTTAATGTTTATGAATGTGTTTTATATGTAATAAATT
GACCAGATTGGGCTAATTAT

Downstream 100 bases:

>100_bases
TTTTTCAGTTTCTTAATTTTAAAAGATAAATGAGATAAAAATTTTTATATCATTTATTCTTGTTTATTTTTAACGCTTAC
TTTATTTGTAATTTAAAGGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKEKSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
IYVFGDFNENEPYIKLFKFLDKSRETIYYLSTSPTFYGPIINNLKKHFVSERLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFREDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRAEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKINREDIKNCIVKGQYIGSQVQGVFKKGYKDETESLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
YGTFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWEDIEICNYFYGSEGPKEIDSILEKDHFWRKI

Sequences:

>Translated_478_residues
MKEKSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
IYVFGDFNENEPYIKLFKFLDKSRETIYYLSTSPTFYGPIINNLKKHFVSERLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFREDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRAEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKINREDIKNCIVKGQYIGSQVQGVFKKGYKDETESLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
YGTFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWEDIEICNYFYGSEGPKEIDSILEKDHFWRKI
>Mature_478_residues
MKEKSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
IYVFGDFNENEPYIKLFKFLDKSRETIYYLSTSPTFYGPIINNLKKHFVSERLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFREDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRAEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKINREDIKNCIVKGQYIGSQVQGVFKKGYKDETESLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
YGTFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWEDIEICNYFYGSEGPKEIDSILEKDHFWRKI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=474, Percent_Identity=34.3881856540084, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI108773793, Length=474, Percent_Identity=34.3881856540084, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI52145310, Length=366, Percent_Identity=29.7814207650273, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=39.0852390852391, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=475, Percent_Identity=36, Blast_Score=316, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=33.0578512396694, Blast_Score=280, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=35.4906054279749, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=35.4906054279749, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=28.7190082644628, Blast_Score=205, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56111; Mature: 56111

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHEECCCCEEEEE
KDSLWQEETDSLIEIFLNFFIYVFGDFNENEPYIKLFKFLDKSRETIYYLSTSPTFYGPI
EHHCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEHHH
INNLKKHFVSERLTLSKIVLEKPFGSSLETAKKLNSLLYSAFREDQIYRIDHYLGKETVQ
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHH
NIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRAEYYDSVGALKDMVQNHILQLLS
HHHHHHCCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAMESPIKFDSEFIHDEKVKVLKSLRKINREDIKNCIVKGQYIGSQVQGVFKKGYKDET
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
ESLGNSNTETYLAMKVFINNWRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSV
HHCCCCCCHHEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHEEEECCCEEEEECCCCC
DFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSYYGTFKRLFDEAYERLLLDAF
CCCCEEEEEECCCCCEEEEEECCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHH
LGDGTLYATSDEIESSWEFVSDIANKWEDIEICNYFYGSEGPKEIDSILEKDHFWRKI
HCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEKSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHEECCCCEEEEE
KDSLWQEETDSLIEIFLNFFIYVFGDFNENEPYIKLFKFLDKSRETIYYLSTSPTFYGPI
EHHCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEHHH
INNLKKHFVSERLTLSKIVLEKPFGSSLETAKKLNSLLYSAFREDQIYRIDHYLGKETVQ
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHH
NIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRAEYYDSVGALKDMVQNHILQLLS
HHHHHHCCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAMESPIKFDSEFIHDEKVKVLKSLRKINREDIKNCIVKGQYIGSQVQGVFKKGYKDET
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
ESLGNSNTETYLAMKVFINNWRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSV
HHCCCCCCHHEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHEEEECCCEEEEECCCCC
DFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSYYGTFKRLFDEAYERLLLDAF
CCCCEEEEEECCCCCEEEEEECCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHH
LGDGTLYATSDEIESSWEFVSDIANKWEDIEICNYFYGSEGPKEIDSILEKDHFWRKI
HCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]