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The map label for this gene is pyrG [H]

Identifier: 51598826

GI number: 51598826

Start: 590007

End: 591608

Strand: Direct

Name: pyrG [H]

Synonym: BG0586

Alternate gene names: 51598826

Gene position: 590007-591608 (Clockwise)

Preceding gene: 51598825

Following gene: 51598828

Centisome position: 65.25

GC content: 32.08

Gene sequence:

>1602_bases
ATGAAAAAAAACTTAAAGATTTTGGTAATAACAGGAGGCGTGATCTCTGGAATTGGGAAAGGAGTTACATCGGCAAGTAT
TGCAAGGTTGTTTAGATATGATTTTAGGGTCACTCCAATCAAATGTGATGGATATTTAAATACTGACCCCGGGACTATTA
ATCCTGTTGAGCATGGAGAAGTTTTTGTGCTTGATGATGGAGGAGAGGTTGATATGGACTTTGGTCATTATGAGAGATTT
TTAAATCTTAATGCGAAGTCTAGTTGGAACATTACAATGGGCAAGATATACAAAAAAATACTTGAAAATGAGCGAAAGGG
TAAATATTTAGGAAGAACAGTTCAGCTTATTCCTCATGTTACTGATGAGATTAAGTCTACAATTTTTCAGATTGCAAGTT
CTGAGAATAGCGAGATGTTGATAATTGAAATTGGTGGAACTGTAGGAGATATGGAAAATATTTTATTTATTGAGACAGTA
AGGCAAATAAGGCATGAGATTGGAAGCGGTAATATTGCTTTTATTCATTTAACCTATGTACCAAGTCCAGCTGGAATTAA
TGAGCAAAAATCTAAACCCACTCAACAGAGTGTTAAAACTTTAAATAAAGCAGGCATTTTCCCCGATCTGATTATTGCTA
GAAGCTCTCAAGTATTAACAGACCAAATCAGAAAAAAAGTGGCAATGTTTTGTAATGTTGAGAGCAATTCTATTATTGAT
AATATTGATGTTTCTACTATTTATGAAATTCCTATATCTTTTTACAAACAAGGCGTACATGAGATTTTAAGTTCTAAGTT
GAATATTAAGGTTGATCCAAAAATAGAAGAGCTTTCAAAGCTTGTAGGAGTTATAAAATCTAATTTTTTTGTGCCTAAAA
AAATTATTAATATTGCCATTTGTGGTAAATATGCTGAACTTGATGATTCTTATGCGTCAATTCGAGAGTCTTTGGTTCAT
GTTGGAGCTAATTTGGATTTACTTATTAAAAGCACTCTAATTGATTCTAATGATTTAAATGAGAGTTATTTAAAAGAGTT
TGACGGCATTATTGTTCCCGGAGGCTTTGGAGGCAAAGGATATGAGGGTAAAATTATTGCTATTAAATACGCTCGTGAAA
ATAACATTCCCTTTCTTGGAATTTGTCTTGGTTTACAGCTTGCTGTAATAGAATTTGCTCGTAATGTTTGCGGGATACTT
GATGCTGATACAGAGGAAAACTTATTAAAAGACAAACCTTTAAAAAGCCCTGTTATTCATTTGCTTCCCGAGCAAAAGGG
AATTAAAGATAAAGGTGCTACAATGAGGCTTGGAGGATATCCTGTGATTCTTAAAAAGAATACAATAGTTTTTAATCTTT
ATGGTCAAGACAGGATAATCGAAAGATTTAGGCACAGATATGAAGTTAATAATGATTATATAGATTTATTTGAGAAAAAT
GGACTTGTAGTATCTGGATTTTCAAGTGATTTTAAAATAGCAAAATTAATAGAAATTCCTAAAAATAAATTTTTTGTAGC
CTGTCAATTTCATCCAGAACTTATTACAAGAATAGAAAATCCAGCTAAGCTTTTTTTAGGGCTAATTAAAGCTTGTATTT
GA

Upstream 100 bases:

>100_bases
TTTTAATGTAAGTAAGCAATGTTTTTATATGTAATTTGTGTGTCTTTTTAAGCGTAAGCTTAATTGGTTTGAAATTTAAA
GGTTTGATTTTGGGGTATAC

Downstream 100 bases:

>100_bases
GTCTCTGTTTATTTACTTAGTGAGTGGGCAGGTTTTCAAAATTAATGTTTGTAGTATTCTCAAATTGCAATACTTTATAG
CTTAAAAATAATTTAGAGAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETV
RQIRHEIGSGNIAFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESNSIID
NIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VGANLDLLIKSTLIDSNDLNESYLKEFDGIIVPGGFGGKGYEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLLKDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIVFNLYGQDRIIERFRHRYEVNNDYIDLFEKN
GLVVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI

Sequences:

>Translated_533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETV
RQIRHEIGSGNIAFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESNSIID
NIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VGANLDLLIKSTLIDSNDLNESYLKEFDGIIVPGGFGGKGYEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLLKDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIVFNLYGQDRIIERFRHRYEVNNDYIDLFEKN
GLVVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI
>Mature_533_residues
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERF
LNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETV
RQIRHEIGSGNIAFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESNSIID
NIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAICGKYAELDDSYASIRESLVH
VGANLDLLIKSTLIDSNDLNESYLKEFDGIIVPGGFGGKGYEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGIL
DADTEENLLKDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTIVFNLYGQDRIIERFRHRYEVNNDYIDLFEKN
GLVVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=552, Percent_Identity=39.6739130434783, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=40.9090909090909, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=40.9090909090909, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=40.9090909090909, Blast_Score=405, Evalue=1e-113,
Organism=Escherichia coli, GI1789142, Length=540, Percent_Identity=41.6666666666667, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25148299, Length=611, Percent_Identity=35.5155482815057, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=39.4316163410302, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=39.4642857142857, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24664469, Length=553, Percent_Identity=40.8679927667269, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI21357815, Length=497, Percent_Identity=39.8390342052314, Blast_Score=356, Evalue=2e-98,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59491; Mature: 59491

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGE
CCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCEECCCCCCCCCCCCCE
VFVLDDGGEVDMDFGHYERFLNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHV
EEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHCCCCCCCHHCHHHHHHHHH
TDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETVRQIRHEIGSGNIAFIHLTYV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
PSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESNSIID
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCC
NIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAI
CCCCEEEEECCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEEE
CGKYAELDDSYASIRESLVHVGANLDLLIKSTLIDSNDLNESYLKEFDGIIVPGGFGGKG
ECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHCCEEEECCCCCCC
YEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLLKDKPLKSPVIH
CCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEE
LLPEQKGIKDKGATMRLGGYPVILKKNTIVFNLYGQDRIIERFRHRYEVNNDYIDLFEKN
ECCCCCCCCCCCCEEEECCEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECC
GLVVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI
CEEEECCCCCCEEEEEEECCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MKKNLKILVITGGVISGIGKGVTSASIARLFRYDFRVTPIKCDGYLNTDPGTINPVEHGE
CCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCEECCCCCCCCCCCCCE
VFVLDDGGEVDMDFGHYERFLNLNAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHV
EEEEECCCCCCCCHHHHHHHEECCCCCCCCEEHHHHHHHHHCCCCCCCHHCHHHHHHHHH
TDEIKSTIFQIASSENSEMLIIEIGGTVGDMENILFIETVRQIRHEIGSGNIAFIHLTYV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
PSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVLTDQIRKKVAMFCNVESNSIID
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCC
NIDVSTIYEIPISFYKQGVHEILSSKLNIKVDPKIEELSKLVGVIKSNFFVPKKIINIAI
CCCCEEEEECCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEEE
CGKYAELDDSYASIRESLVHVGANLDLLIKSTLIDSNDLNESYLKEFDGIIVPGGFGGKG
ECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHCCEEEECCCCCCC
YEGKIIAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLLKDKPLKSPVIH
CCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEE
LLPEQKGIKDKGATMRLGGYPVILKKNTIVFNLYGQDRIIERFRHRYEVNNDYIDLFEKN
ECCCCCCCCCCCCEEEECCEEEEEECCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECC
GLVVSGFSSDFKIAKLIEIPKNKFFVACQFHPELITRIENPAKLFLGLIKACI
CEEEECCCCCCEEEEEEECCCCCEEEEEEECHHHHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA