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The map label for this gene is gntT

Identifier: 51598087

GI number: 51598087

Start: 4528450

End: 4529766

Strand: Direct

Name: gntT

Synonym: YPTB3797

Alternate gene names: 51598087

Gene position: 4528450-4529766 (Clockwise)

Preceding gene: 51598081

Following gene: 51598090

Centisome position: 95.44

GC content: 50.95

Gene sequence:

>1317_bases
ATGCCATTAATCATCGTCGCGGTTGGCGTTGCCATGCTGCTATTACTGATGATCCGTTACAAACTTAACGGATTTATCTC
GCTGATACTGGTCGCGTTAGCGGTAGGTATCATGCAAGGGATGCCAATCGATAAAGTTGTCGGCTCGATCAAAGCGGGTG
TCGGCGGAACATTAGGTAGCCTGGCCTTGATTATGGGCTTCGGGGCCATGCTCGGTAAATTGCTGGCCGATTGTGGCGGC
GCTCAACGTATCGCGACCACCTTAATTGAGAAGTTTGGTCAAAAACATATTCAATGGGCTGTGGTACTGACCGGCTTTAC
TGTGGGTTTTGCCCTGTTTTATGAAGTGGGTTTTGTGCTGTTATTGCCGCTGGTATTCAGCATTGCGGCCTCTGCCCGCA
TTCCCTTGCTATATGTGGGTGTTCCCATGGCGGCGGCGCTTTCTGTCACTCATGGTTTTCTGCCACCTCACCCAGGCCCG
ACAGCCATTGCCACCATTTTCAGCGCCGATATGGGCAAAACGCTGCTGTACGGCACATTGCTGGCAATCCCAACCGTGAT
TTTGGCAGGCCCGGTCTACGCTCGCTTTCTAAAAGGAATTGATAAGCCTGTTCCTGAAGGGCTGTATAACCCGAAAATCT
TTACCGATAAAGAGATGCCAAGCTTTGGAGTCAGTGTCAGTACGGCGCTGGTACCGGTTATTTTGATGGCATTGCGGGCC
GTAGCAGAGATGATTTTGCCTAAAGGCCATTCGCTGCTCCCCTATGCCGAGTTCTTTGGTGATCCAGTAATTGCTACGCT
GATTGCCGTGTTAATTGCAATTTTCACCTTTGGTCTAAACCGGGGCCGCTCAGTGGAATCGGTCATGGAGACCCTGTCTG
ATTCCATCAAGATCATCGCAATGATGCTGTTAGTTATTGGAGGCGGCGGTGCTTTCAAGCAGGTTTTAGTCGATAGCGGC
ATAGAGCAATATATTGCTGGCATGATGGGCAATAGCGGGGCATCGCCTATTCTGATGGCATGGTCCATCGCCGCCTTACT
GCGTATCGCCCTGGGTTCTGCGACGGTAGCAGCGATCACCGCTGGGGGCATTGTCGCACCGTTAATCGCGACCACCGGTG
CCAGCCCTGAGTTGATGGTCATTGCCGTTGGTTCCGGTAGCGTGATCTTCTCTCACGTGAATGACCCTGGTTTCTGGCTA
TTCAAGGAGTATTTCAACCTAACCATTATGGAAACCATTAAATCGTGGTCAGTACTGGAAACCATTATTTCAGTCTGCGG
GTTGATCGGCTGTTTGTTGCTGTCTCTGGTTATTTAG

Upstream 100 bases:

>100_bases
ATAGCGCCGTTATCACAATAGATAAAACAGCTATCACGACAGATAAAAAACACTGCCTTCGTACTCAATCACGCGAGCCA
GGAAAGGCCGGAGAAATATT

Downstream 100 bases:

>100_bases
CCAACGGCGCGATAAATAGTCGTTATATAAATGGCTGTTATATAAATGGTTATTATGTAAATAGTTACTATATAAATGAT
TGCTATATTTTTTATATACT

Product: indonate/gluconate permease

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPLIIVAVGVAMLLLLMIRYKLNGFISLILVALAVGIMQGMPIDKVVGSIKAGVGGTLGSLALIMGFGAMLGKLLADCGG
AQRIATTLIEKFGQKHIQWAVVLTGFTVGFALFYEVGFVLLLPLVFSIAASARIPLLYVGVPMAAALSVTHGFLPPHPGP
TAIATIFSADMGKTLLYGTLLAIPTVILAGPVYARFLKGIDKPVPEGLYNPKIFTDKEMPSFGVSVSTALVPVILMALRA
VAEMILPKGHSLLPYAEFFGDPVIATLIAVLIAIFTFGLNRGRSVESVMETLSDSIKIIAMMLLVIGGGGAFKQVLVDSG
IEQYIAGMMGNSGASPILMAWSIAALLRIALGSATVAAITAGGIVAPLIATTGASPELMVIAVGSGSVIFSHVNDPGFWL
FKEYFNLTIMETIKSWSVLETIISVCGLIGCLLLSLVI

Sequences:

>Translated_438_residues
MPLIIVAVGVAMLLLLMIRYKLNGFISLILVALAVGIMQGMPIDKVVGSIKAGVGGTLGSLALIMGFGAMLGKLLADCGG
AQRIATTLIEKFGQKHIQWAVVLTGFTVGFALFYEVGFVLLLPLVFSIAASARIPLLYVGVPMAAALSVTHGFLPPHPGP
TAIATIFSADMGKTLLYGTLLAIPTVILAGPVYARFLKGIDKPVPEGLYNPKIFTDKEMPSFGVSVSTALVPVILMALRA
VAEMILPKGHSLLPYAEFFGDPVIATLIAVLIAIFTFGLNRGRSVESVMETLSDSIKIIAMMLLVIGGGGAFKQVLVDSG
IEQYIAGMMGNSGASPILMAWSIAALLRIALGSATVAAITAGGIVAPLIATTGASPELMVIAVGSGSVIFSHVNDPGFWL
FKEYFNLTIMETIKSWSVLETIISVCGLIGCLLLSLVI
>Mature_437_residues
PLIIVAVGVAMLLLLMIRYKLNGFISLILVALAVGIMQGMPIDKVVGSIKAGVGGTLGSLALIMGFGAMLGKLLADCGGA
QRIATTLIEKFGQKHIQWAVVLTGFTVGFALFYEVGFVLLLPLVFSIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPT
AIATIFSADMGKTLLYGTLLAIPTVILAGPVYARFLKGIDKPVPEGLYNPKIFTDKEMPSFGVSVSTALVPVILMALRAV
AEMILPKGHSLLPYAEFFGDPVIATLIAVLIAIFTFGLNRGRSVESVMETLSDSIKIIAMMLLVIGGGGAFKQVLVDSGI
EQYIAGMMGNSGASPILMAWSIAALLRIALGSATVAAITAGGIVAPLIATTGASPELMVIAVGSGSVIFSHVNDPGFWLF
KEYFNLTIMETIKSWSVLETIISVCGLIGCLLLSLVI

Specific function: Part of the gluconate utilization system Gnt-I; high- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994935, Length=438, Percent_Identity=85.1598173515982, Blast_Score=735, Evalue=0.0,
Organism=Escherichia coli, GI1790716, Length=438, Percent_Identity=61.1872146118721, Blast_Score=546, Evalue=1e-157,
Organism=Escherichia coli, GI2367370, Length=449, Percent_Identity=51.2249443207127, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790776, Length=438, Percent_Identity=40.1826484018265, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1788707, Length=435, Percent_Identity=37.0114942528736, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI48994939, Length=434, Percent_Identity=36.6359447004608, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789097, Length=442, Percent_Identity=33.710407239819, Blast_Score=217, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 45764; Mature: 45633

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIIVAVGVAMLLLLMIRYKLNGFISLILVALAVGIMQGMPIDKVVGSIKAGVGGTLGS
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
LALIMGFGAMLGKLLADCGGAQRIATTLIEKFGQKHIQWAVVLTGFTVGFALFYEVGFVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPLVFSIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFSADMGKTLLYGTL
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LAIPTVILAGPVYARFLKGIDKPVPEGLYNPKIFTDKEMPSFGVSVSTALVPVILMALRA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VAEMILPKGHSLLPYAEFFGDPVIATLIAVLIAIFTFGLNRGRSVESVMETLSDSIKIIA
HHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
MMLLVIGGGGAFKQVLVDSGIEQYIAGMMGNSGASPILMAWSIAALLRIALGSATVAAIT
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
AGGIVAPLIATTGASPELMVIAVGSGSVIFSHVNDPGFWLFKEYFNLTIMETIKSWSVLE
HCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIISVCGLIGCLLLSLVI
HHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PLIIVAVGVAMLLLLMIRYKLNGFISLILVALAVGIMQGMPIDKVVGSIKAGVGGTLGS
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
LALIMGFGAMLGKLLADCGGAQRIATTLIEKFGQKHIQWAVVLTGFTVGFALFYEVGFVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPLVFSIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFSADMGKTLLYGTL
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LAIPTVILAGPVYARFLKGIDKPVPEGLYNPKIFTDKEMPSFGVSVSTALVPVILMALRA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VAEMILPKGHSLLPYAEFFGDPVIATLIAVLIAIFTFGLNRGRSVESVMETLSDSIKIIA
HHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
MMLLVIGGGGAFKQVLVDSGIEQYIAGMMGNSGASPILMAWSIAALLRIALGSATVAAIT
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
AGGIVAPLIATTGASPELMVIAVGSGSVIFSHVNDPGFWLFKEYFNLTIMETIKSWSVLE
HCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIISVCGLIGCLLLSLVI
HHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 2845225; 7984428; 3040894; 9045817 [H]