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The map label for this gene is htrA

Identifier: 51595099

GI number: 51595099

Start: 900329

End: 901774

Strand: Direct

Name: htrA

Synonym: YPTB0749

Alternate gene names: 51595099

Gene position: 900329-901774 (Clockwise)

Preceding gene: 51595098

Following gene: 51595101

Centisome position: 18.98

GC content: 49.65

Gene sequence:

>1446_bases
ATGAAAAAAACAACTTTAGTATTAAGTGCATTGGCATTGAGCATTGGTTTCGCCATGGGCCCGGTTTCTTCCGTCGTTGC
GGCAGAGACGGCAGCATCGAGTAGCCAGCAGCTCCCTAGCCTGGCGCCAATGCTAGAGAAAGTAATGCCTTCAGTGGTCA
GTATCAACGTTGAAGGTAGTGCGCCTGTAAGCAGTGCTGGTGCACGCGGTATGCCACCACAATTCCAGCAGTTTTTTGGT
GATAACTCGCCATTCTGTCAGGACGGTTCACCGTTCCAAGGCTCGCCAATGTGTCAAGGGGATCTGGGCGGACTAGGGCA
GGGAATGCCAAGTAAGCGGGAATTCCGTTCGCTTGGTTCAGGTGTCATTATTGATGCGGGCAAGGGGTATGTCGTTACCA
ATAACCACGTGGTCGATAATGCGAACAAGATCAGCGTAAAACTGAGCGATGGCCGCAGTTTTGATGCCAAGGTGATCGGT
AAAGATCCACGTACCGATATCGCACTGTTACAACTGAAAGACGCTAAAAATCTGACTGCGATTAAGATTGCCAATTCGGA
TCAACTGCGTGTCGGTGATTATACCGTCGCTATCGGGAACCCGTATGGCTTGGGTGAAACCGTGACATCCGGTATTGTCT
CTGCTTTAGGGCGCAGTGGTTTGAATGTAGAAAACTATGAAAACTTTATCCAGACTGATGCGGCGATTAACCGCGGTAAT
TCCGGCGGCGCATTAATCAACCTGAACGGTGAGTTGATTGGTATTAACACCGCTATTCTGGCACCGGATGGCGGTAACAT
TGGTATTGGCTTTGCTATCCCAAGCAACATGGTGAAGAACCTGACATCACAGATGGTTGAGTTTGGTCAGGTAAAACGCG
GTGAACTGGGCATTATGGGGACCGAGCTAAACTCTGAACTGGCAAAAGCCATGAAGGTTGATGCGCAGAAAGGTGCCTTT
ATCAGCCAGGTCGTGCCTAAATCTGCTGCGGCAAAAGCGGGTATCAAAGCGGGCGATATCATTGTCAGTATGAATGGGAA
AGCCATCAATAGTTTTGCAGGGTTCCGCGCCGAGATCGGCACGTTACCTGTTGGCAGCAAAATGACCTTGGGTCTGCTGC
GTGATGGCAAACCGATCAATGTGAATGTCGTCCTGGAGCAGAGCAGCCACAGTCAGGTGGAATCCGGTAATCTCTACACC
GGTATTGAGGGGGCTGAACTGAGTAACAGCAACGTTAGCGGCAAGAAAGGGGTGAAAGTTGATAGCGTAAAACCAGGCAC
TGCTGCGGCGCGTATCGGCCTGAAAAAAGGTGATATCATAATGGGGATTAACCAGCAACCAGTCCAGAACCTAGGTGAGC
TGCGGAAAATCCTCGATGCTAAACCACCGGTATTGGCGTTGAATATTCAACGTGGTGATACTTCACTCTATTTATTGATG
CAGTAA

Upstream 100 bases:

>100_bases
CCCCATATTTAATCTTACTAGGCAAGACGGCATACGGCATTAGTCGGCCACATAGTCGCTATTTATTCATTTTTAATTTG
TATAGTGAGAACACGAATAT

Downstream 100 bases:

>100_bases
GGTATTGATGCAGTAAGGTATTGACACAATAGATGCAGTAACGGGTCTCAATGCAGTAAAGATTATGTAGATCCCGTGTG
ATTTCCATTTAGCTCAAGGG

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKKTTLVLSALALSIGFAMGPVSSVVAAETAASSSQQLPSLAPMLEKVMPSVVSINVEGSAPVSSAGARGMPPQFQQFFG
DNSPFCQDGSPFQGSPMCQGDLGGLGQGMPSKREFRSLGSGVIIDAGKGYVVTNNHVVDNANKISVKLSDGRSFDAKVIG
KDPRTDIALLQLKDAKNLTAIKIANSDQLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGN
SGGALINLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQKGAF
ISQVVPKSAAAKAGIKAGDIIVSMNGKAINSFAGFRAEIGTLPVGSKMTLGLLRDGKPINVNVVLEQSSHSQVESGNLYT
GIEGAELSNSNVSGKKGVKVDSVKPGTAAARIGLKKGDIIMGINQQPVQNLGELRKILDAKPPVLALNIQRGDTSLYLLM
Q

Sequences:

>Translated_481_residues
MKKTTLVLSALALSIGFAMGPVSSVVAAETAASSSQQLPSLAPMLEKVMPSVVSINVEGSAPVSSAGARGMPPQFQQFFG
DNSPFCQDGSPFQGSPMCQGDLGGLGQGMPSKREFRSLGSGVIIDAGKGYVVTNNHVVDNANKISVKLSDGRSFDAKVIG
KDPRTDIALLQLKDAKNLTAIKIANSDQLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGN
SGGALINLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQKGAF
ISQVVPKSAAAKAGIKAGDIIVSMNGKAINSFAGFRAEIGTLPVGSKMTLGLLRDGKPINVNVVLEQSSHSQVESGNLYT
GIEGAELSNSNVSGKKGVKVDSVKPGTAAARIGLKKGDIIMGINQQPVQNLGELRKILDAKPPVLALNIQRGDTSLYLLM
Q
>Mature_481_residues
MKKTTLVLSALALSIGFAMGPVSSVVAAETAASSSQQLPSLAPMLEKVMPSVVSINVEGSAPVSSAGARGMPPQFQQFFG
DNSPFCQDGSPFQGSPMCQGDLGGLGQGMPSKREFRSLGSGVIIDAGKGYVVTNNHVVDNANKISVKLSDGRSFDAKVIG
KDPRTDIALLQLKDAKNLTAIKIANSDQLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGN
SGGALINLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMGTELNSELAKAMKVDAQKGAF
ISQVVPKSAAAKAGIKAGDIIVSMNGKAINSFAGFRAEIGTLPVGSKMTLGLLRDGKPINVNVVLEQSSHSQVESGNLYT
GIEGAELSNSNVSGKKGVKVDSVKPGTAAARIGLKKGDIIMGINQQPVQNLGELRKILDAKPPVLALNIQRGDTSLYLLM
Q

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=256, Percent_Identity=39.453125, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI22129776, Length=250, Percent_Identity=35.2, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=34.2741935483871, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI7019477, Length=252, Percent_Identity=35.3174603174603, Blast_Score=133, Evalue=5e-31,
Organism=Escherichia coli, GI1786356, Length=482, Percent_Identity=75.3112033195021, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=483, Percent_Identity=55.2795031055901, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789630, Length=350, Percent_Identity=37.7142857142857, Blast_Score=208, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24646839, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49866; Mature: 49866

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLVLSALALSIGFAMGPVSSVVAAETAASSSQQLPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEEEECCC
APVSSAGARGMPPQFQQFFGDNSPFCQDGSPFQGSPMCQGDLGGLGQGMPSKREFRSLGS
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
GVIIDAGKGYVVTNNHVVDNANKISVKLSDGRSFDAKVIGKDPRTDIALLQLKDAKNLTA
CEEEECCCCEEEECCEEECCCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCEEE
IKIANSDQLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGN
EEEECCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
SGGALINLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMG
CCCEEEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEE
TELNSELAKAMKVDAQKGAFISQVVPKSAAAKAGIKAGDIIVSMNGKAINSFAGFRAEIG
CCHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHCCCCCCCEEEEECCCEEHHHCCCCEECC
TLPVGSKMTLGLLRDGKPINVNVVLEQSSHSQVESGNLYTGIEGAELSNSNVSGKKGVKV
CCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEE
DSVKPGTAAARIGLKKGDIIMGINQQPVQNLGELRKILDAKPPVLALNIQRGDTSLYLLM
CCCCCCCHHHEECCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
Q
C
>Mature Secondary Structure
MKKTTLVLSALALSIGFAMGPVSSVVAAETAASSSQQLPSLAPMLEKVMPSVVSINVEGS
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEEEECCC
APVSSAGARGMPPQFQQFFGDNSPFCQDGSPFQGSPMCQGDLGGLGQGMPSKREFRSLGS
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
GVIIDAGKGYVVTNNHVVDNANKISVKLSDGRSFDAKVIGKDPRTDIALLQLKDAKNLTA
CEEEECCCCEEEECCEEECCCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCEEE
IKIANSDQLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGN
EEEECCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
SGGALINLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEFGQVKRGELGIMG
CCCEEEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEE
TELNSELAKAMKVDAQKGAFISQVVPKSAAAKAGIKAGDIIVSMNGKAINSFAGFRAEIG
CCHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHCCCCCCCEEEEECCCEEHHHCCCCEECC
TLPVGSKMTLGLLRDGKPINVNVVLEQSSHSQVESGNLYTGIEGAELSNSNVSGKKGVKV
CCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEE
DSVKPGTAAARIGLKKGDIIMGINQQPVQNLGELRKILDAKPPVLALNIQRGDTSLYLLM
CCCCCCCHHHEECCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]