Click here to switch to the map view.

The map label for this gene is hmuU

Identifier: 51594692

GI number: 51594692

Start: 402235

End: 403239

Strand: Reverse

Name: hmuU

Synonym: YPTB0337

Alternate gene names: 51594692

Gene position: 403239-402235 (Counterclockwise)

Preceding gene: 51594693

Following gene: 51594691

Centisome position: 8.5

GC content: 55.72

Gene sequence:

>1005_bases
ATGAATGGTCGTGTTCAGCCACGACTGATGCTGGGCTTCTTACTGATATTGCTAGTCATTCTGGCGCTGGGCTCAGCTAA
TATGGGGGCCTTATCGCTCTCATTTCGCACGCTATGGAACACCTCCACCAATGATGCCATGTGGCACATTTGGTTGAATA
TCCGCCTGCCACGGGTGTTATTGGCTGTCGTGGTGGGGTGTGCATTGGCGGTCTCCGGCACCATTATGCAAGGGTTATTC
CGTAACCCGCTGGCGGACCCAGGTTTGTTGGGCATCAGTAGCGGCGCAGCGCTTTGCGTCGGGCTGATTATCGTGATGCC
TTTCAGCCTACCGCCGTTACTCGCGCTGTATAGCCATATGGTTGGGGCCTTTATCGGCAGTCTGGCTATTTCTACTATTA
TTTTTACCCTCAGCCGTTGGGGGCATGGCAATCTGGCTCGTCTACTGCTAGCCGGTATTGCGATTAATGCCTTATGCGGT
GCGGCGGTTGGGGTGCTGACCTATATCAGTGATGACCAACAATTACGCCAGTTCTCGCTATGGAGTATGGGGAGTTTAGG
GCAAGCGCAGTGGTCGACACTGCTGGTCGCATCCTCCCTGATCCTGCCTACCTGTATTTTGGGGCTGCTACAGGCCCGCC
AACTGAATTTGTTGCAGTTGGGGGATGAAGAAGCACACTACCTTGGCGTCAATGTTCGGCAAGCCAAACTACGCTTACTG
CTACTCAGTGCCATCCTGATTGGTGCCGCGGTGGCGGTCAGTGGCGTGATCGGCTTTATCGGGTTGGTGGTGCCACATCT
GATCCGTATGCGTATCGGCGCGGATCATCGTTGGTTGCTACCCGGCGCGGCGTTGGGGGGGGCCTGCCTGCTACTGACGG
CCGATACACTGGCTCGCACACTGGTTGCTCCGGCGGAAATGCCCGTCGGTCTGTTAACCAGCCTGTTGGGTGGGCCTTAT
TTTCTGTGGCTGATTTTACGTCAGCGGGAGCAACGCAGTGGTTGA

Upstream 100 bases:

>100_bases
ATAAACGCCTGTTGGTCGTGGATGATATGGCATTACTTGGCTTTGGTCTGGAAACACCACAAGTGCTTGCACAGCTACGT
GAAAAAATGGAACAGATGCA

Downstream 100 bases:

>100_bases
TATGGCAGTAACACCCGTCGCATTATTAGAGGCCAGCCACCTCCATTATCATGTACAACAGCAAGCGCTGATTAATGATG
TTTCGCTGCACATCGCCAGT

Product: ABC hemin transporter, permease subunit HmuU

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNGRVQPRLMLGFLLILLVILALGSANMGALSLSFRTLWNTSTNDAMWHIWLNIRLPRVLLAVVVGCALAVSGTIMQGLF
RNPLADPGLLGISSGAALCVGLIIVMPFSLPPLLALYSHMVGAFIGSLAISTIIFTLSRWGHGNLARLLLAGIAINALCG
AAVGVLTYISDDQQLRQFSLWSMGSLGQAQWSTLLVASSLILPTCILGLLQARQLNLLQLGDEEAHYLGVNVRQAKLRLL
LLSAILIGAAVAVSGVIGFIGLVVPHLIRMRIGADHRWLLPGAALGGACLLLTADTLARTLVAPAEMPVGLLTSLLGGPY
FLWLILRQREQRSG

Sequences:

>Translated_334_residues
MNGRVQPRLMLGFLLILLVILALGSANMGALSLSFRTLWNTSTNDAMWHIWLNIRLPRVLLAVVVGCALAVSGTIMQGLF
RNPLADPGLLGISSGAALCVGLIIVMPFSLPPLLALYSHMVGAFIGSLAISTIIFTLSRWGHGNLARLLLAGIAINALCG
AAVGVLTYISDDQQLRQFSLWSMGSLGQAQWSTLLVASSLILPTCILGLLQARQLNLLQLGDEEAHYLGVNVRQAKLRLL
LLSAILIGAAVAVSGVIGFIGLVVPHLIRMRIGADHRWLLPGAALGGACLLLTADTLARTLVAPAEMPVGLLTSLLGGPY
FLWLILRQREQRSG
>Mature_334_residues
MNGRVQPRLMLGFLLILLVILALGSANMGALSLSFRTLWNTSTNDAMWHIWLNIRLPRVLLAVVVGCALAVSGTIMQGLF
RNPLADPGLLGISSGAALCVGLIIVMPFSLPPLLALYSHMVGAFIGSLAISTIIFTLSRWGHGNLARLLLAGIAINALCG
AAVGVLTYISDDQQLRQFSLWSMGSLGQAQWSTLLVASSLILPTCILGLLQARQLNLLQLGDEEAHYLGVNVRQAKLRLL
LLSAILIGAAVAVSGVIGFIGLVVPHLIRMRIGADHRWLLPGAALGGACLLLTADTLARTLVAPAEMPVGLLTSLLGGPY
FLWLILRQREQRSG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily

Homologues:

Organism=Escherichia coli, GI1790740, Length=323, Percent_Identity=39.938080495356, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=42.4460431654676, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790741, Length=279, Percent_Identity=39.7849462365591, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786805, Length=303, Percent_Identity=37.6237623762376, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786804, Length=280, Percent_Identity=37.5, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786347, Length=290, Percent_Identity=34.4827586206897, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMUU_YERPE (Q56992)

Other databases:

- EMBL:   U60647
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0035
- PIR:   T12072
- RefSeq:   NP_667877.1
- RefSeq:   NP_991829.1
- RefSeq:   YP_002345362.1
- ProteinModelPortal:   Q56992
- SMR:   Q56992
- GeneID:   1145487
- GeneID:   1173126
- GeneID:   2764130
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0280
- KEGG:   ypk:y0540
- KEGG:   ypm:YP_0435
- HOGENOM:   HBG700016
- OMA:   HRWLLPC
- ProtClustDB:   CLSK880697
- BioCyc:   YPES187410:Y0540-MONOMER
- BioCyc:   YPES214092:YPO0280-MONOMER
- InterPro:   IPR000522

Pfam domain/function: PF01032 FecCD

EC number: NA

Molecular weight: Translated: 35540; Mature: 35540

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18563778)-; HASH(0x1051cd58)-; HASH(0x18a021b4)-; HASH(0x1820aca8)-; HASH(0xd7c31f4)-; HASH(0x1779b1c8)-; HASH(0x1836772c)-; HASH(0x18437df0)-; HASH(0x18b02b3c)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRVQPRLMLGFLLILLVILALGSANMGALSLSFRTLWNTSTNDAMWHIWLNIRLPRVL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCEEEEEEEECCHHHHH
LAVVVGCALAVSGTIMQGLFRNPLADPGLLGISSGAALCVGLIIVMPFSLPPLLALYSHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHH
VGAFIGSLAISTIIFTLSRWGHGNLARLLLAGIAINALCGAAVGVLTYISDDQQLRQFSL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
WSMGSLGQAQWSTLLVASSLILPTCILGLLQARQLNLLQLGDEEAHYLGVNVRQAKLRLL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCHHHHHHHHH
LLSAILIGAAVAVSGVIGFIGLVVPHLIRMRIGADHRWLLPGAALGGACLLLTADTLART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHCCHHHHHHHHHHHHH
LVAPAEMPVGLLTSLLGGPYFLWLILRQREQRSG
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MNGRVQPRLMLGFLLILLVILALGSANMGALSLSFRTLWNTSTNDAMWHIWLNIRLPRVL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCEEEEEEEECCHHHHH
LAVVVGCALAVSGTIMQGLFRNPLADPGLLGISSGAALCVGLIIVMPFSLPPLLALYSHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHH
VGAFIGSLAISTIIFTLSRWGHGNLARLLLAGIAINALCGAAVGVLTYISDDQQLRQFSL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
WSMGSLGQAQWSTLLVASSLILPTCILGLLQARQLNLLQLGDEEAHYLGVNVRQAKLRLL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCHHHHHHHHH
LLSAILIGAAVAVSGVIGFIGLVVPHLIRMRIGADHRWLLPGAALGGACLLLTADTLART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHCCHHHHHHHHHHHHH
LVAPAEMPVGLLTSLLGGPYFLWLILRQREQRSG
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430